 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, December 1, 1999, 19(23):10357-10371
Sequence of Neuron Origin and Neocortical Laminar Fate: Relation to Cell Cycle of Origin in the Developing Murine Cerebral Wall
T. Takahashi1, 2, T. Goto1, 2, S. Miyama1, 2, R. S. Nowakowski3, and V. S. Caviness Jr1 1 Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, 2 Department of Pediatrics, Keio University School of Medicine, Tokyo 160, Japan, and 3 Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854
Neurons destined for each region of the neocortex are known to arise approximately in an "inside-to-outside" sequence from a pseudostratified ventricular epithelium (PVE). This sequence is initiated rostrolaterally and propagates caudomedially. Moreover, independently of location in the PVE, the neuronogenetic sequence in mouse is divisible into 11 cell cycles that occur over a 6 d period. Here we use a novel "birth hour" method that identifies small cohorts of neurons born during a single 2 hr period, i.e., 10-20% of a single cell cycle, which corresponds to ~1.5% of the 6 d neuronogenetic period. This method shows that neurons arising with the same cycle of the 11 cycle sequence in mouse have common laminar fates even if they arise from widely separated positions on the PVE (neurons of fields 1 and 40) and therefore arise at different embryonic times. Even at this high level of temporal resolution, simultaneously arising cells occupy more than one cortical layer, and there is substantial overlap in the distributions of cells arising with successive cycles. We demonstrate additionally that the laminar representation of cells arising with a given cycle is little if at all modified over the early postnatal interval of histogenetic cell death. We infer from these findings that cell cycle is a neuronogenetic counting mechanism and that this counting mechanism is integral to subsequent processes that determine cortical laminar fate.
Key words: neocortical histogenesis; neuronogenesis; pseudostratified ventricular epithelium (PVE); cell cycle; neuronogenetic sequence; transverse neuronogenetic gradient
Copyright © 1999 Society for Neuroscience 0270-6474/99/192310357-15$05.00/0
This article has been cited by other articles:
Y. Muroyama and T. Saito
Identification of Nepro, a gene required for the maintenance of neocortex neural progenitor cells downstream of Notch
Development, December 1, 2009; 136(23): 3889 - 3893.
[Abstract] [Full Text] [PDF]
C. D. Kroenke, E. N. Taber, L. A. Leigland, A. K. Knutsen, and P. V. Bayly
Regional Patterns of Cerebral Cortical Differentiation Determined by Diffusion Tensor MRI
Cereb Cortex, December 1, 2009; 19(12): 2916 - 2929.
[Abstract] [Full Text] [PDF]
C. A. Mutch, N. Funatsu, E. S. Monuki, and A. Chenn
{beta}-Catenin Signaling Levels in Progenitors Influence the Laminar Cell Fates of Projection Neurons
J. Neurosci., October 28, 2009; 29(43): 13710 - 13719.
[Abstract] [Full Text] [PDF]
T. C. Tuoc, K. Radyushkin, A. B. Tonchev, M. C. Pinon, R. Ashery-Padan, Z. Molnar, M. S. Davidoff, and A. Stoykova
Selective Cortical Layering Abnormalities and Behavioral Deficits in Cortex-Specific Pax6 Knock-Out Mice
J. Neurosci., July 1, 2009; 29(26): 8335 - 8349.
[Abstract] [Full Text] [PDF]
H. Li, G. Chen, B. Zhou, and S. Duan
Actin Filament Assembly by Myristoylated, Alanine-rich C Kinase Substrate-Phosphatidylinositol-4,5-diphosphate Signaling Is Critical for Dendrite Branching
Mol. Biol. Cell, November 1, 2008; 19(11): 4804 - 4813.
[Abstract] [Full Text] [PDF]
J. A. Siegenthaler, B. A. Tremper-Wells, and M. W. Miller
Foxg1 Haploinsufficiency Reduces the Population of Cortical Intermediate Progenitor Cells: Effect of Increased p21 Expression
Cereb Cortex, August 1, 2008; 18(8): 1865 - 1875.
[Abstract] [Full Text] [PDF]
S. J. Harrison, R. Nishinakamura, and A. P. Monaghan
Sall1 Regulates Mitral Cell Development and Olfactory Nerve Extension in the Developing Olfactory Bulb
Cereb Cortex, July 1, 2008; 18(7): 1604 - 1617.
[Abstract] [Full Text] [PDF]
N. Makris, S. L. Buka, J. Biederman, G. M. Papadimitriou, S. M. Hodge, E. M. Valera, A. B. Brown, G. Bush, M. C. Monuteaux, V. S. Caviness, et al.
Attention and Executive Systems Abnormalities in Adults with Childhood ADHD: A DT-MRI Study of Connections
Cereb Cortex, May 1, 2008; 18(5): 1210 - 1220.
[Abstract] [Full Text] [PDF]
G. Estivill-Torrus, P. Llebrez-Zayas, E. Matas-Rico, L. Santin, C. Pedraza, I. De Diego, I. Del Arco, P. Fernandez-Llebrez, J. Chun, and F. R. De Fonseca
Absence of LPA1 Signaling Results in Defective Cortical Development
Cereb Cortex, April 1, 2008; 18(4): 938 - 950.
[Abstract] [Full Text] [PDF]
M. R. Costa, G. Wen, A. Lepier, T. Schroeder, and M. Gotz
Par-complex proteins promote proliferative progenitor divisions in the developing mouse cerebral cortex
Development, January 1, 2008; 135(1): 11 - 22.
[Abstract] [Full Text] [PDF]
I. Hack, S. Hellwig, D. Junghans, B. Brunne, H. H. Bock, S. Zhao, and M. Frotscher
Divergent roles of ApoER2 and Vldlr in the migration of cortical neurons
Development, November 1, 2007; 134(21): 3883 - 3891.
[Abstract] [Full Text] [PDF]
J. L. Vanderluit, C. A. Wylie, K. A. McClellan, N. Ghanem, A. Fortin, S. Callaghan, J. G. MacLaurin, D. S. Park, and R. S. Slack
The Retinoblastoma family member p107 regulates the rate of progenitor commitment to a neuronal fate
J. Cell Biol., October 3, 2007; 178(1): 129 - 139.
[Abstract] [Full Text] [PDF]
B. Suter, R. S. Nowakowski, P. G. Bhide, and V. S. Caviness
Navigating Neocortical Neurogenesis and Neuronal Specification: A Positional Information System Encoded by Neurogenetic Gradients
J. Neurosci., October 3, 2007; 27(40): 10777 - 10784.
[Abstract] [Full Text] [PDF]
R. R. Romito-DiGiacomo, H. Menegay, S. A. Cicero, and K. Herrup
Effects of Alzheimer's Disease on Different Cortical Layers: The Role of Intrinsic Differences in A{beta} Susceptibility
J. Neurosci., August 8, 2007; 27(32): 8496 - 8504.
[Abstract] [Full Text] [PDF]
P. Sathyan, H. B. Golden, and R. C. Miranda
Competing Interactions between Micro-RNAs Determine Neural Progenitor Survival and Proliferation after Ethanol Exposure: Evidence from an Ex Vivo Model of the Fetal Cerebral Cortical Neuroepithelium
J. Neurosci., August 8, 2007; 27(32): 8546 - 8557.
[Abstract] [Full Text] [PDF]
A. Takeuchi, T. Hamasaki, E. D. Litwack, and D. D.M. O'Leary
Novel IgCAM, MDGA1, Expressed in Unique Cortical Area- and Layer-Specific Patterns and Transiently by Distinct Forebrain Populations of Cajal-Retzius Neurons
Cereb Cortex, July 1, 2007; 17(7): 1531 - 1541.
[Abstract] [Full Text] [PDF]
Y. Itoh, N. Masuyama, K. Nakayama, K. I. Nakayama, and Y. Gotoh
The Cyclin-dependent Kinase Inhibitors p57 and p27 Regulate Neuronal Migration in the Developing Mouse Neocortex
J. Biol. Chem., January 5, 2007; 282(1): 390 - 396.
[Abstract] [Full Text] [PDF]
G. J. Woodhead, C. A. Mutch, E. C. Olson, and A. Chenn
Cell-Autonomous beta-Catenin Signaling Regulates Cortical Precursor Proliferation
J. Neurosci., November 29, 2006; 26(48): 12620 - 12630.
[Abstract] [Full Text] [PDF]
R. Pla, V. Borrell, N. Flames, and O. Marin
Layer acquisition by cortical GABAergic interneurons is independent of Reelin signaling.
J. Neurosci., June 28, 2006; 26(26): 6924 - 6934.
[Abstract] [Full Text] [PDF]
A. Takeuchi and D. D. M. O'Leary
Radial migration of superficial layer cortical neurons controlled by novel Ig cell adhesion molecule MDGA1.
J. Neurosci., April 26, 2006; 26(17): 4460 - 4464.
[Abstract] [Full Text] [PDF]
E. C. Olson, S. Kim, and C. A. Walsh
Impaired Neuronal Positioning and Dendritogenesis in the Neocortex after Cell-Autonomous Dab1 Suppression
J. Neurosci., February 8, 2006; 26(6): 1767 - 1775.
[Abstract] [Full Text] [PDF]
M. Yoshida, S. Assimacopoulos, K. R. Jones, and E. A. Grove
Massive loss of Cajal-Retzius cells does not disrupt neocortical layer order
Development, February 1, 2006; 133(3): 537 - 545.
[Abstract] [Full Text] [PDF]
J. Udagawa, R. Hashimoto, H. Suzuki, T. Hatta, Y. Sotomaru, K. Hioki, Y. Kagohashi, T. Nomura, Y. Minami, and H. Otani
The Role of Leptin in the Development of the Cerebral Cortex in Mouse Embryos
Endocrinology, February 1, 2006; 147(2): 647 - 658.
[Abstract] [Full Text] [PDF]
S.-X. Wu, S. Goebbels, K. Nakamura, K. Nakamura, K. Kometani, N. Minato, T. Kaneko, K.-A. Nave, and N. Tamamaki
Pyramidal neurons of upper cortical layers generated by NEX-positive progenitor cells in the subventricular zone
PNAS, November 22, 2005; 102(47): 17172 - 17177.
[Abstract] [Full Text] [PDF]
T. Tarui, T. Takahashi, R.S. Nowakowski, N.L. Hayes, P.G. Bhide, and V.S. Caviness
Overexpression of p27Kip1, Probability of Cell Cycle Exit, and Laminar Destination of Neocortical Neurons
Cereb Cortex, September 1, 2005; 15(9): 1343 - 1355.
[Abstract] [Full Text] [PDF]
S. N. Sansom, J. M. Hebert, U. Thammongkol, J. Smith, G. Nisbet, M. A. Surani, S. K. McConnell, and F. J. Livesey
Genomic characterisation of a Fgf-regulated gradient-based neocortical protomap
Development, September 1, 2005; 132(17): 3947 - 3961.
[Abstract] [Full Text] [PDF]
J. A. Bourne, C. E. Warner, and M. G.P. Rosa
Topographic and Laminar Maturation of Striate Cortex in Early Postnatal Marmoset Monkeys, as Revealed by Neurofilament Immunohistochemistry
Cereb Cortex, June 1, 2005; 15(6): 740 - 748.
[Abstract] [Full Text] [PDF]
K.-i. Mizutani and T. Saito
Progenitors resume generating neurons after temporary inhibition of neurogenesis by Notch activation in the mammalian cerebral cortex
Development, March 15, 2005; 132(6): 1295 - 1304.
[Abstract] [Full Text] [PDF]
M. Andres, V. M. Andre, S. Nguyen, N. Salamon, C. Cepeda, M. S. Levine, J. P. Leite, L. Neder, H. V. Vinters, and G. W. Mathern
Human Cortical Dysplasia and Epilepsy: An Ontogenetic Hypothesis Based on Volumetric MRI and NeuN Neuronal Density and Size Measurements
Cereb Cortex, February 1, 2005; 15(2): 194 - 210.
[Abstract] [Full Text] [PDF]
W. Sun, A. Winseck, S. Vinsant, O.-h. Park, H. Kim, and R. W. Oppenheim
Programmed Cell Death of Adult-Generated Hippocampal Neurons Is Mediated by the Proapoptotic Gene Bax
J. Neurosci., December 8, 2004; 24(49): 11205 - 11213.
[Abstract] [Full Text] [PDF]
C. Zimmer, M.-C. Tiveron, R. Bodmer, and H. Cremer
Dynamics of Cux2 Expression Suggests that an Early Pool of SVZ Precursors is Fated to Become Upper Cortical Layer Neurons
Cereb Cortex, December 1, 2004; 14(12): 1408 - 1420.
[Abstract] [Full Text] [PDF]
K. Yun, A. Mantani, S. Garel, J. Rubenstein, and M. A. Israel
Id4 regulates neural progenitor proliferation and differentiation in vivo
Development, November 1, 2004; 131(21): 5441 - 5448.
[Abstract] [Full Text] [PDF]
K. Roy, K. Kuznicki, Q. Wu, Z. Sun, D. Bock, G. Schutz, N. Vranich, and A. P. Monaghan
The Tlx Gene Regulates the Timing of Neurogenesis in the Cortex
J. Neurosci., September 22, 2004; 24(38): 8333 - 8345.
[Abstract] [Full Text] [PDF]
T. Miyata, A. Kawaguchi, K. Saito, M. Kawano, T. Muto, and M. Ogawa
Asymmetric production of surface-dividing and non-surface-dividing cortical progenitor cells
Development, July 1, 2004; 131(13): 3133 - 3145.
[Abstract] [Full Text] [PDF]
S. Rumpel, G. Kattenstroth, and K. Gottmann
Silent Synapses in the Immature Visual Cortex: Layer-Specific Developmental Regulation
J Neurophysiol, February 1, 2004; 91(2): 1097 - 1101.
[Abstract] [Full Text] [PDF]
M. Hashimoto and K. Mikoshiba
Neuronal Birthdate-Specific Gene Transfer with Adenoviral Vectors
J. Neurosci., January 7, 2004; 24(1): 286 - 296.
[Abstract] [Full Text] [PDF]
P. W. Land and A. P. Monaghan
Expression of the Transcription Factor, tailless, Is Required for Formation of Superficial Cortical Layers
Cereb Cortex, September 1, 2003; 13(9): 921 - 931.
[Abstract] [Full Text] [PDF]
V.S. Caviness Jr, T. Goto, T. Tarui, T. Takahashi, P.G. Bhide, and R.S. Nowakowski
Cell Output, Cell Cycle Duration and Neuronal Specification: a Model of Integrated Mechanisms of the Neocortical Proliferative Process
Cereb Cortex, June 1, 2003; 13(6): 592 - 598.
[Abstract] [Full Text] [PDF]
H. L. P. Bahrey and W. J. Moody
Voltage-gated Currents, Dye and Electrical Coupling in the Embryonic Mouse Neocortex
Cereb Cortex, March 1, 2003; 13(3): 239 - 251.
[Abstract] [Full Text] [PDF]
Y. Sugitani, S. Nakai, O. Minowa, M. Nishi, K.-i. Jishage, H. Kawano, K. Mori, M. Ogawa, and T. Noda
Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons
Genes & Dev., July 15, 2002; 16(14): 1760 - 1765.
[Abstract] [Full Text] [PDF]
T. Hatta, K. Moriyama, K. Nakashima, T. Taga, and H. Otani
The Role of gp130 in Cerebral Cortical Development: In Vivo Functional Analysis in a Mouse Exo Utero System
J. Neurosci., July 1, 2002; 22(13): 5516 - 5524.
[Abstract] [Full Text] [PDF]
R. A. Rachel, G. Dolen, N. L. Hayes, A. Lu, L. Erskine, R. S. Nowakowski, and C. A. Mason
Spatiotemporal Features of Early Neuronogenesis Differ in Wild-Type and Albino Mouse Retina
J. Neurosci., June 1, 2002; 22(11): 4249 - 4263.
[Abstract] [Full Text] [PDF]
R. G. Carey, B. Li, and E. DiCicco-Bloom
Pituitary Adenylate Cyclase Activating Polypeptide Anti-Mitogenic Signaling in Cerebral Cortical Progenitors Is Regulated by p57Kip2-Dependent CDK2 Activity
J. Neurosci., March 1, 2002; 22(5): 1583 - 1591.
[Abstract] [Full Text] [PDF]
R. J. McEvilly, M. O. de Diaz, M. D. Schonemann, F. Hooshmand, and M. G. Rosenfeld
Transcriptional Regulation of Cortical Neuron Migration by POU Domain Factors
Science, February 22, 2002; 295(5559): 1528 - 1532.
[Abstract] [Full Text] [PDF]
C. Dehay, P. Savatier, V. Cortay, and H. Kennedy
Cell-Cycle Kinetics of Neocortical Precursors Are Influenced by Embryonic Thalamic Axons
J. Neurosci., January 1, 2001; 21(1): 201 - 214.
[Abstract] [Full Text] [PDF]
R. Raballo, J. Rhee, R. Lyn-Cook, J. F. Leckman, M. L. Schwartz, and F. M. Vaccarino
Basic Fibroblast Growth Factor (Fgf2) Is Necessary for Cell Proliferation and Neurogenesis in the Developing Cerebral Cortex
J. Neurosci., July 1, 2000; 20(13): 5012 - 5023.
[Abstract] [Full Text] [PDF]
M. Groszer, R. Erickson, D. D. Scripture-Adams, R. Lesche, A. Trumpp, J. A. Zack, H. I. Kornblum, X. Liu, and H. Wu
Negative Regulation of Neural Stem/Progenitor Cell Proliferation by the Pten Tumor Suppressor Gene in Vivo
Science, December 7, 2001; 294(5549): 2186 - 2189.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|