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Previous Article | Next Article
The Journal of Neuroscience, December 15, 1999, 19(24):10672-10679
Differences in Expression of Acetylcholinesterase and Collagen Q Control the Distribution and Oligomerization of the Collagen-Tailed Forms in Fast and Slow Muscles
Eric Krejci1, Claire Legay1, Sébastien Thomine1, Janez Sketelj2, and Jean Massoulié1 1 Laboratoire de Neurobiologie Cellulaire et Moléculaire, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8544, Ecole Normale Supérieure, 75005 Paris, France, and 2 Institute of Pathophysiology, School of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia
The collagen-tailed forms of acetylcholinesterase (AChE) are accumulated at mammalian neuromuscular junctions. The A4, A8, and A12 forms are expressed differently in the rat fast and slow muscles; the sternomastoid muscle contains essentially the A12 form at end plates, whereas the soleus muscle also contains extrajunctional A4 and A8 forms. We show that collagen Q (ColQ) transcripts become exclusively junctional in the adult sternomastoid but remain uniformly expressed in the soleus. By coinjecting Xenopus oocytes with AChET and ColQ mRNAs, we reproduced the muscle patterns of collagen-tailed forms. The soleus contains transcripts ColQ1 and ColQ1a, whereas the sternomastoid only contains ColQ1a. Collagen-tailed AChE represents the first evidence that synaptic components involved in cholinergic transmission may be differently regulated in fast and slow muscles.
Key words: neuromuscular junction; acetylcholinesterase; collagen; fast muscle; slow muscle; rat
Copyright © 1999 Society for Neuroscience 0270-6474/99/192410672-08$05.00/0
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