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The Journal of Neuroscience, December 15, 1999, 19(24):10931-10939
Saccadic Dysmetria and Adaptation after Lesions of the Cerebellar Cortex
Shabtai Barash1, Armenuhi Melikyan1, Alexey Sivakov1, Mingsha Zhang1, Mitchell Glickstein2, and Peter Thier3 1 Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel, 2 Department of Anatomy, University College London, London WC1E 6BT, United Kingdom, and 3 Sektion für Visuelle Sensomotorik, Neurologische Universitätsklinik Tübingen, 72076 Tübingen, Germany
We studied the effects of small lesions of the oculomotor vermis of the cerebellar cortex on the ability of monkeys to execute and adapt saccadic eye movements. For saccades in one horizontal direction, the lesions led to an initial gross hypometria and a permanent abolition of the capacity for rapid adaptation. Mean saccade amplitude recovered from the initial hypometria, although variability remained high. A series of hundreds of repetitive saccades in the same direction resulted in gradual decrement of amplitude. Saccades in other directions were less strongly affected by the lesions. We suggest the following. (1) The cerebellar cortex is constantly recalibrating the saccadic system, thus compensating for rapid biomechanical changes such as might be caused by muscle fatigue. (2) A mechanism capable of slow recovery from dysmetria is revealed despite the permanent absence of rapid adaptation.
Key words: saccades; saccadic eye movement; saccadic adaptation; fatigue; cerebellum; vermis; dysmetria; lesion; eye movement; recovery; recovery from brain damage; motor learning; cerebellar cortex
Copyright © 1999 Society for Neuroscience 0270-6474/99/192410931-09$05.00/0
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