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The Journal of Neuroscience, December 15, 1999, 19(24):10940-10947
Cerebellar Cortex Lesions Prevent Acquisition of Conditioned Eyelid Responses
Keith S. Garcia, Philip M. Steele, and Michael D. Mauk Department of Neurobiology and Anatomy and The Keck Center for the Neurobiology of Learning and Memory, University of Texas Medical School, Houston, Texas 77030
We have used aspiration and electrolytic lesions to investigate the contributions of cerebellar cortex to the acquisition and expression of conditioned eyelid responses. We show that lesions of the anterior lobe of rabbit cerebellar cortex disrupt the timing of previously learned conditioned eyelid responses. These short-latency responses were used as an indication that the cerebellar cortex was sufficiently damaged and that the underlying pathways necessary for the expression of responses were sufficiently intact to support responses. Rabbits were subsequently trained for 15 daily sessions using a new conditioned stimulus. Whereas rabbits in which lesions had no significant effect on response timing showed rapid acquisition of appropriately timed eyelid responses to the new conditioned stimulus, animals with lesions that disrupt timing showed no significant increases in either amplitude or probability of responses. Histological analysis suggests that damage to the anterior lobe of the cerebellar cortex is necessary and sufficient to abolish timing and prevent acquisition. These data indicate that the cerebellar cortex is necessary for the acquisition of conditioned eyelid responses and are consistent with the hypotheses that (1) eyelid conditioning results in plasticity in both the anterior lobe of the cerebellar cortex and in the anterior interpositus nucleus and (2) induction of plasticity in the interpositus requires intact input from the cerebellar cortex.
Key words: Pavlovian eyelid conditioning; classical eyelid conditioning; nictitating membrane; LTP; LTD; motor learning; extinction; timing; deep cerebellar nucleus
Copyright © 1999 Society for Neuroscience 0270-6474/99/192410940-08$05.00/0
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