 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, December 15, 1999, 19(24):11027-11039
Modulation of Basolateral Amygdala Neuronal Firing and Afferent Drive by Dopamine Receptor Activation In Vivo
J. Amiel Rosenkranz and Anthony A. Grace Departments of Neuroscience and Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260
The basolateral amygdala (BLA) is implicated in responding to affective stimuli. Dopamine (DA) is released in the BLA during numerous conditions; however, the neurophysiological effects of DA in the BLA have not been examined in depth. In this study, the effects of DA receptor manipulation on spontaneous and afferent-driven neuronal firing were examined using in vivo extracellular single-unit recordings in parallel with systemic and iontophoretic drug application, and stimulation of the substantia nigra/ventral tegmental area in the rat. The effects of DA receptor activation in the BLA were found to depend on the characteristics of the BLA neuron examined, causing an increase in the firing rate of putative interneurons and a decrease in the firing of identified projection neurons. Additionally, DA receptor activation attenuated short-latency spikes evoked by electrical stimulation of prefrontal cortical and mediodorsal thalamic inputs to the BLA while potentiating the responses evoked by electrical stimulation of sensory association cortex.
DA receptor activation can thus attenuate BLA projection neuron firing via two mechanisms: (1) by a direct inhibition, and (2) by indirect actions mediated via activation of BLA interneurons. This is hypothesized to lead to a global filtration of weaker inputs. Moreover, DA potentiates sensory inputs and attenuates medial prefrontal cortex inputs to the BLA. Conditions in which DA is released in the BLA, such as during the presentation of an affective stimulus, will lead to a potentiation of the strongest sensory input and a dampening of cortical inhibition over the BLA, thus augmenting the response to affective sensory stimuli.
Key words: dopamine; basolateral amygdala; projection neuron; interneuron; afferent; electrophysiology; iontophoresis; substantia nigra; ventral tegmental area; modulation
Copyright © 1999 Society for Neuroscience 0270-6474/99/192411027-13$05.00/0
This article has been cited by other articles:
A. R. Woodruff and P. Sah
Inhibition and Synchronization of Basal Amygdala Principal Neuron Spiking by Parvalbumin-Positive Interneurons
J Neurophysiol, November 1, 2007; 98(5): 2956 - 2961.
[Abstract] [Full Text] [PDF]
I. Liberzon, A. P. King, J. C. Britton, K. L. Phan, J. L. Abelson, and S. F. Taylor
Paralimbic and Medial Prefrontal Cortical Involvement in Neuroendocrine Responses to Traumatic Stimuli
Am J Psychiatry, August 1, 2007; 164(8): 1250 - 1258.
[Abstract] [Full Text] [PDF]
R. Yamamoto, Y. Ueta, and N. Kato
Dopamine Induces a Slow Afterdepolarization in Lateral Amygdala Neurons
J Neurophysiol, August 1, 2007; 98(2): 984 - 992.
[Abstract] [Full Text] [PDF]
E. Likhtik, J. G. Pelletier, A. T. Popescu, and D. Pare
Identification of Basolateral Amygdala Projection Cells and Interneurons Using Extracellular Recordings
J Neurophysiol, December 1, 2006; 96(6): 3257 - 3265.
[Abstract] [Full Text] [PDF]
D. Bowers, K. Miller, A. Mikos, L. Kirsch-Darrow, U. Springer, H. Fernandez, K. Foote, and M. Okun
Startling facts about emotion in Parkinson's disease: blunted reactivity to aversive stimuli
Brain, December 1, 2006; 129(12): 3356 - 3365.
[Abstract] [Full Text] [PDF]
T. Ahmed, J. U. Frey, and V. Korz
Long-Term Effects of Brief Acute Stress on Cellular Signaling and Hippocampal LTP
J. Neurosci., April 12, 2006; 26(15): 3951 - 3958.
[Abstract] [Full Text] [PDF]
P. A. R. Manzanares, N. A. Isoardi, H. F. Carrer, and V. A. Molina
Previous Stress Facilitates Fear Memory, Attenuates GABAergic Inhibition, and Increases Synaptic Plasticity in the Rat Basolateral Amygdala
J. Neurosci., September 21, 2005; 25(38): 8725 - 8734.
[Abstract] [Full Text] [PDF]
S. Kroner, J. A. Rosenkranz, A. A. Grace, and G. Barrionuevo
Dopamine Modulates Excitability of Basolateral Amygdala Neurons In Vitro
J Neurophysiol, March 1, 2005; 93(3): 1598 - 1610.
[Abstract] [Full Text] [PDF]
F. Frenois, L. Stinus, F. Di Blasi, M. Cador, and C. Le Moine
A Specific Limbic Circuit Underlies Opiate Withdrawal Memories
J. Neurosci., February 9, 2005; 25(6): 1366 - 1374.
[Abstract] [Full Text] [PDF]
M. N. Smolka, G. Schumann, J. Wrase, S. M. Grusser, H. Flor, K. Mann, D. F. Braus, D. Goldman, C. Buchel, and A. Heinz
Catechol-O-Methyltransferase val158met Genotype Affects Processing of Emotional Stimuli in the Amygdala and Prefrontal Cortex
J. Neurosci., January 26, 2005; 25(4): 836 - 842.
[Abstract] [Full Text] [PDF]
F. Sotres-Bayon, D. E.A. Bush, and J. E. LeDoux
Emotional Perseveration: An Update on Prefrontal-Amygdala Interactions in Fear Extinction
Learn. Mem., September 1, 2004; 11(5): 525 - 535.
[Abstract] [Full Text] [PDF]
Y.-C. Huang, S.-J. Wang, L.-C. Chiou, and P.-W. Gean
Mediation of Amphetamine-Induced Long-Term Depression of Synaptic Transmission by CB1 Cannabinoid Receptors in the Rat Amygdala
J. Neurosci., November 12, 2003; 23(32): 10311 - 10320.
[Abstract] [Full Text] [PDF]
J. L. Fudge and A. B. Emiliano
The Extended Amygdala and the Dopamine System: Another Piece of the Dopamine Puzzle
J Neuropsychiatry Clin Neurosci, August 1, 2003; 15(3): 306 - 316.
[Abstract] [Full Text]
A. Tessitore, A. R. Hariri, F. Fera, W. G. Smith, T. N. Chase, T. M. Hyde, D. R. Weinberger, and V. S. Mattay
Dopamine Modulates the Response of the Human Amygdala: A Study in Parkinson's Disease
J. Neurosci., October 15, 2002; 22(20): 9099 - 9103.
[Abstract] [Full Text] [PDF]
J. A. Rosenkranz and A. A. Grace
Cellular Mechanisms of Infralimbic and Prelimbic Prefrontal Cortical Inhibition and Dopaminergic Modulation of Basolateral Amygdala Neurons In Vivo
J. Neurosci., January 1, 2002; 22(1): 324 - 337.
[Abstract] [Full Text] [PDF]
J. A. Rosenkranz and A. A. Grace
Dopamine Attenuates Prefrontal Cortical Suppression of Sensory Inputs to the Basolateral Amygdala of Rats
J. Neurosci., June 1, 2001; 21(11): 4090 - 4103.
[Abstract] [Full Text] [PDF]
S. P. Mendoza and J. D. Ruys
The beginning of an alternative view of the neurobiology of emotion
Social Science Information, March 1, 2001; 40(1): 39 - 60.
[Abstract] [PDF]
H. E. W. Day, A. Badiani, J. M. Uslaner, M. M. Oates, N. M. Vittoz, T. E. Robinson, S. J. Watson Jr, and H. Akil
Environmental Novelty Differentially Affects c-fos mRNA Expression Induced by Amphetamine or Cocaine in Subregions of the Bed Nucleus of the Stria Terminalis and Amygdala
J. Neurosci., January 15, 2001; 21(2): 732 - 740.
[Abstract] [Full Text] [PDF]
P. J. Kruzich and R. E. See
Differential Contributions of the Basolateral and Central Amygdala in the Acquisition and Expression of Conditioned Relapse to Cocaine-Seeking Behavior
J. Neurosci., July 15, 2001; 21(14): RC155 - RC155.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|