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The Journal of Neuroscience, December 15, 1999, 19(24):11061-11071
Thalamic-Cortical-Striatal Circuitry Subserves Working Memory
during Delayed Responding on a Radial Arm Maze
Stan B.
Floresco,
Deanna N.
Braaksma, and
Anthony G.
Phillips
Department of Psychology, University of British Columbia,
Vancouver, British Columbia, Canada V6T 1Z4
The medial dorsal nuclei of the thalamus (MDNt), the prefrontal
cortex, and the ventral striatum form an interconnected neural circuit
that may subserve certain types of working memory. The present series
of experiments investigated functional interactions between these brain
regions in rats during the performance of delayed and nondelayed
spatially cued radial-arm maze tasks. In Experiment 1, transient
inactivation of the MDNt by a bilateral injection of lidocaine
selectively disrupted performance on a delayed task but not on a
nondelayed random foraging version of the radial arm maze task. In
Experiment 2, asymmetrical lidocaine injections into the MDNt on one
side of the brain and the prefrontal cortex on the other transiently
disconnected these two brain regions and significantly impaired
foraging during the delayed task. Similarly, disconnections between the
prefrontal cortex and the nucleus accumbens also disrupted foraging on
this task, whereas disconnections between the MDNt and the nucleus
accumbens had no effect. These data suggest that serial transmission of
information among the MDNt, the prefrontal cortex, and the nucleus
accumbens is required when trial-unique, short-term spatial memory is
used to guide prospective search behavior. The results are discussed
with respect to a distributed neural network linking limbic, thalamic,
cortical, and striatal regions, which mediates executive functions of
working memory.
Key words:
medial-dorsal thalamus; prefrontal cortex; nucleus
accumbens; working memory; neural networks; lidocaine-induced
reversible lesions; rats
Copyright © 1999 Society for Neuroscience 0270-6474/99/192411061-11$05.00/0
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