QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (38) Citing Articles via Google Scholar Google Scholar Articles by Borjigin, J. Articles by Snyder, S. H. Search for Related Content PubMed PubMed Citation Articles by Borjigin, J. Articles by Snyder, S. H.

 Previous Article  |  Next Article 

The Journal of Neuroscience, February 1, 1999, 19(3):1018-1026

A Novel Pineal Night-Specific ATPase Encoded by the Wilson Disease Gene

Jimo Borjigin¹, Aimee S. Payne², Jie Deng¹, Xiaodong Li¹, Michael M. Wang³, Boris Ovodenko¹, Jonathan D. Gitlin², and Solomon H. Snyder^{1, 4, 5}

Departments of ¹ Neuroscience, ³ Neurology, ⁴ Pharmacology and Molecular Science, and ⁵ Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, and ² The Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110

We have identified a pineal night-specific ATPase (PINA), a novel splice variant of the ATP7B gene disrupted in Wilson disease (WD). PINA expression exhibits a dramatic diurnal rhythm in both pineal gland and retina with 100-fold greater expression at night than at day. PINA is expressed in pinealocytes and a subset of photoreceptors in adult rats and is transiently expressed in the retinal pigment epithelium and the ciliary body during retinal development. Nocturnal pineal expression of PINA is under the control of a suprachiasmatic nucleus clock mediated by superior cervical ganglion innervation of the pineal. In vitro, PINA expression in pineal cells can be stimulated by agents activating the cAMP signal transduction pathway. PINA is able to restore copper transport activity in Saccharomyces cerevisiae deficient in the homologous copper-transporting ATPase CCC2, suggesting that this protein may function as a copper transporter in rat pinealocytes. These studies suggest a potential role of rhythmic copper metabolism in pineal and/or retina circadian function.

Key words: pineal; P-type ATPase; Wilson disease; circadian rhythms; photoreceptor; development

---

Copyright © 1999 Society for Neuroscience  0270-6474/99/1931018-09$05.00/0

This article has been cited by other articles:

				S. Lutsenko, N. L. Barnes, M. Y. Bartee, and O. Y. Dmitriev Function and Regulation of Human Copper-Transporting ATPases Physiol Rev, July 1, 2007; 87(3): 1011 - 1046. [Abstract] [Full Text] [PDF]

				P. Krajacic, Y. Qian, P. Hahn, T. Dentchev, N. Lukinova, and J. L. Dunaief Retinal localization and copper-dependent relocalization of the Wilson and menkes disease proteins. Invest. Ophthalmol. Vis. Sci., July 1, 2006; 47(7): 3129 - 3134. [Abstract] [Full Text] [PDF]

				P. Gaildrat, M. Moller, S. Mukda, A. Humphries, D. A. Carter, V. Ganapathy, and D. C. Klein A Novel Pineal-specific Product of the Oligopeptide Transporter PepT1 Gene: CIRCADIAN EXPRESSION MEDIATED BY cAMP ACTIVATION OF AN INTRONIC PROMOTER J. Biol. Chem., April 29, 2005; 280(17): 16851 - 16860. [Abstract] [Full Text] [PDF]

				J. Borjigin, J. Deng, X. Sun, M. De Jesus, T. Liu, and M. M. Wang Diurnal Pineal 3-O-Sulphotransferase 2 Expression Controlled by beta -Adrenergic Repression J. Biol. Chem., April 25, 2003; 278(18): 16315 - 16319. [Abstract] [Full Text] [PDF]

				J. Borjigin, J. Deng, M. M. Wang, X. Li, S. Blackshaw, and S. H. Snyder Circadian Rhythm of Patched1 Transcription in the Pineal Regulated by Adrenergic Stimulation and cAMP J. Biol. Chem., December 3, 1999; 274(49): 35012 - 35015. [Abstract] [Full Text] [PDF]

				M. M. O. Peña, J. Lee, and D. J. Thiele A Delicate Balance: Homeostatic Control of Copper Uptake and Distribution J. Nutr., July 1, 1999; 129(7): 1251 - 1260. [Abstract] [Full Text]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help