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The Journal of Neuroscience, February 1, 1999, 19(3):1106-1114
Temporally Graded Retrograde Amnesia of Contextual Fear after
Hippocampal Damage in Rats: Within-Subjects Examination
Stephan G.
Anagnostaras1,
Stephen
Maren2, and
Michael
S.
Fanselow1
1 Department of Psychology and Brain Research
Institute, University of California, Los Angeles, California
90095-1563, and 2 Department of Psychology and Neuroscience
Program, University of Michigan, Ann Arbor, Michigan 48109
We have shown previously that electrolytic lesions of the dorsal
hippocampus (DH) produce a severe deficit in contextual fear if made
1 d, but not 28 d, after fear conditioning (). As such, the hippocampus seems to play a time-limited role in
the consolidation of contextual fear conditioning. Here, we examine
retrograde amnesia of contextual fear produced by DH lesions in
a within-subjects design. Unlike our previous reports, rats had both a
remote and recent memory at the time of the lesion. Rats were given 10 tone-shock pairings in one context (remote memory) and 10 tone-shock
pairings in a distinct context (with a different tone) 50 d later
(recent memory), followed by DH or sham lesions 1 d later.
Relative to controls, DH-lesioned rats exhibited no deficit in remote
contextual fear, but recent contextual fear memory was severely
impaired. They also did not exhibit deficits in tone freezing. This
highly specific deficit in recent contextual memory demonstrated in a
within-subjects design favors mnemonic over performance accounts of
hippocampal involvement in fear. These findings also provide further
support for a time-limited role of the hippocampus in memory storage.
Key words:
retrograde amnesia; hippocampus; context; fear; conditioning; freezing; rat; activity; consolidation; learning; memory
Copyright © 1999 Society for Neuroscience 0270-6474/99/1931106-09$05.00/0
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