WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience Discover www.zeiss.de/functionality
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (153)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Akiyama, M.
Right arrow Articles by Shibata, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Akiyama, M.
Right arrow Articles by Shibata, S.

 Previous Article  |  Next Article 

The Journal of Neuroscience, February 1, 1999, 19(3):1115-1121

Inhibition of Light- or Glutamate-Induced mPer1 Expression Represses the Phase Shifts into the Mouse Circadian Locomotor and Suprachiasmatic Firing Rhythms

Masashi Akiyama1, Yasuko Kouzu1, Satomi Takahashi1, Hisanori Wakamatsu1, Takahiro Moriya2, Miyuki Maetani3, Shigenori Watanabe3, Hajime Tei4, Yoshiyuki Sakaki4, and Shigenobu Shibata1, 2

1 Department of Pharmacology and Brain Science and 2 ARCHS, School of Human Sciences, Waseda University, Tokorozawa, Saitama 359-1192, Japan, 3 Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-82, Japan, and 4 Human Genome Center, Institute of Medical Sciences, University of Tokyo, Tokyo, Japan

mPer1, a mouse gene, is a homolog of the Drosophila clock gene period and has been shown to be closely associated with the light-induced resetting of a mammalian circadian clock. To investigate whether the rapid induction of mPer1 after light exposure is necessary for light-induced phase shifting, we injected an antisense phosphotioate oligonucleotide (ODN) to mPer1 mRNA into the cerebral ventricle. Light-induced phase delay of locomotor activity at CT16 was significantly inhibited when the mice were pretreated with mPer1 antisense ODN 1 hr before light exposure. mPer1 sense ODN or random ODN treatment had little effect on phase delay induced by light pulses. In addition, glutamate-induced phase delay of suprachiasmatic nucleus (SCN) firing rhythm was attenuated by pretreatment with mPer1 antisense ODN, but not by random ODN. The present results demonstrate that induction of mPer1 mRNA is required for light- or glutamate-induced phase shifting, suggesting that the acute induction of mPer1 mRNA in the SCN after light exposure is involved in light-induced phase shifting of the overt rhythm.

Key words: antisense oligonucleotide; circadian rhythm; firing rhythm; mPer1; phase shift; suprachiasmatic nucleus

Copyright © 1999 Society for Neuroscience  0270-6474/99/1931115-07$05.00/0


This article has been cited by other articles:


Home page
 J Biol RhythmsHome page
J. C. Ehlen, C. M. Novak, M. C. Karom, K. L. Gamble, and H. E. Albers
Interactions of GABAA Receptor Activation and Light on Period mRNA Expression in the Suprachiasmatic Nucleus
J Biol Rhythms, February 1, 2008; 23(1): 16 - 25.
[Abstract] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. R. Pulivarthy, N. Tanaka, D. K. Welsh, L. De Haro, I. M. Verma, and S. Panda
Reciprocity between phase shifts and amplitude changes in the mammalian circadian clock
PNAS, December 18, 2007; 104(51): 20356 - 20361.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
E. Challet
Minireview: Entrainment of the Suprachiasmatic Clockwork in Diurnal and Nocturnal Mammals
Endocrinology, December 1, 2007; 148(12): 5648 - 5655.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
K. L. Gamble, G. C. Allen, T. Zhou, and D. G. McMahon
Gastrin-Releasing Peptide Mediates Light-Like Resetting of the Suprachiasmatic Nucleus Circadian Pacemaker through cAMP Response Element-Binding Protein and Per1 Activation
J. Neurosci., October 31, 2007; 27(44): 12078 - 12087.
[Abstract] [Full Text] [PDF]

Home page
 J Biol RhythmsHome page
M. Doi, S. Cho, I. Yujnovsky, J. Hirayama, N. Cermakian, A. C. B. Cato, and P. Sassone-Corsi
Light-Inducible and Clock-Controlled Expression of MAP Kinase Phosphatase 1 in Mouse Central Pacemaker Neurons
J Biol Rhythms, April 1, 2007; 22(2): 127 - 139.
[Abstract] [PDF]

Home page
 GENES CELLSHome page
N. Takashima, A. Fujioka, N. Hayasaka, A. Matsuo, J. Takasaki, and Y. Shigeyoshi
Gq/11-induced intracellular calcium mobilization mediates Per2 acute induction in Rat-1 fibroblasts.
Genes Cells, September 1, 2006; 11(9): 1039 - 1049.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. T. Sellix, M. Egli, M. O. Poletini, D. T. McKee, M. D. Bosworth, C. A. Fitch, and M. E. Freeman
Anatomical and functional characterization of clock gene expression in neuroendocrine dopaminergic neurons
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2006; 290(5): R1309 - R1323.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
I. Yujnovsky, J. Hirayama, M. Doi, E. Borrelli, and P. Sassone-Corsi
Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK:BMAL1
PNAS, April 18, 2006; 103(16): 6386 - 6391.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. Numano, S. Yamazaki, N. Umeda, T. Samura, M. Sujino, R.-i. Takahashi, M. Ueda, A. Mori, K. Yamada, Y. Sakaki, et al.
Constitutive expression of the Period1 gene impairs behavioral and molecular circadian rhythms.
PNAS, March 7, 2006; 103(10): 3716 - 3721.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Yamamoto, Y. Nakahata, M. Tanaka, M. Yoshida, H. Soma, K. Shinohara, A. Yasuda, T. Mamine, and T. Takumi
Acute Physical Stress Elevates Mouse Period1 mRNA Expression in Mouse Peripheral Tissues via a Glucocorticoid-responsive Element
J. Biol. Chem., December 23, 2005; 280(51): 42036 - 42043.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
K. Ushijima, H. Sakaguchi, Y. Sato, H. To, S. Koyanagi, S. Higuchi, and S. Ohdo
Chronopharmacological Study of Antidepressants in Forced Swimming Test of Mice
J. Pharmacol. Exp. Ther., November 1, 2005; 315(2): 764 - 770.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
W. Nakamura, S. Yamazaki, N. N. Takasu, K. Mishima, and G. D. Block
Differential Response of Period 1 Expression within the Suprachiasmatic Nucleus
J. Neurosci., June 8, 2005; 25(23): 5481 - 5487.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. Q. Butcher, B. Lee, H.-Y. M. Cheng, and K. Obrietan
Light Stimulates MSK1 Activation in the Suprachiasmatic Nucleus via a PACAP-ERK/MAP Kinase-Dependent Mechanism
J. Neurosci., June 1, 2005; 25(22): 5305 - 5313.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Viyoch, N. Matsunaga, M. Yoshida, H. To, S. Higuchi, and S. Ohdo
Effect of Haloperidol on mPer1 Gene Expression in Mouse Suprachiasmatic Nuclei
J. Biol. Chem., February 25, 2005; 280(8): 6309 - 6315.
[Abstract] [Full Text] [PDF]

Home page
 J Biol RhythmsHome page
M. H. Hastings and E. D. Herzog
Clock Genes, Oscillators, and Cellular Networks in the Suprachiasmatic Nuclei
J Biol Rhythms, October 1, 2004; 19(5): 400 - 413.
[Abstract] [PDF]

Home page
 Mol. Cell. Biol.Home page
Y. Naruse, K. Oh-hashi, N. Iijima, M. Naruse, H. Yoshioka, and M. Tanaka
Circadian and Light-Induced Transcription of Clock Gene Per1 Depends on Histone Acetylation and Deacetylation
Mol. Cell. Biol., July 15, 2004; 24(14): 6278 - 6287.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
Y. Sato, E. Kobayashi, Y. Hakamata, M. Kobahashi, T. Wainai, T. Murayama, M. Mishina, and N. Seo
Chronopharmacological studies of ketamine in normal and NMDA {epsilon}1 receptor knockout mice{dagger}
Br. J. Anaesth., June 1, 2004; 92(6): 859 - 864.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
J. W. Barnes, S. A. Tischkau, J. A. Barnes, J. W. Mitchell, P. W. Burgoon, J. R. Hickok, and M. U. Gillette
Requirement of Mammalian Timeless for Circadian Rhythmicity
Science, October 17, 2003; 302(5644): 439 - 442.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. Hamada, J. LeSauter, M. Lokshin, M.-T. Romero, L. Yan, J. M. Venuti, and R. Silver
Calbindin Influences Response to Photic Input in Suprachiasmatic Nucleus
J. Neurosci., October 1, 2003; 23(26): 8820 - 8826.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Nagano, A. Adachi, K.-i. Nakahama, T. Nakamura, M. Tamada, E. Meyer-Bernstein, A. Sehgal, and Y. Shigeyoshi
An Abrupt Shift in the Day/Night Cycle Causes Desynchrony in the Mammalian Circadian Center
J. Neurosci., July 9, 2003; 23(14): 6141 - 6151.
[Abstract] [Full Text] [PDF]

Home page
 J Biol RhythmsHome page
J. H. Meijer and W. J. Schwartz
In Search of the Pathways for Light-Induced Pacemaker Resetting in the Suprachiasmatic Nucleus
J Biol Rhythms, June 1, 2003; 18(3): 235 - 249.
[Abstract] [PDF]

Home page
 J Biol RhythmsHome page
K. Bae and D. R. Weaver
Light-Induced Phase Shifts in Mice Lacking mPER1 or mPER2
J Biol Rhythms, April 1, 2003; 18(2): 123 - 133.
[Abstract] [PDF]

Home page
 J. Neurosci.Home page
S. J. Kuhlman, R. Silver, J. Le Sauter, A. Bult-Ito, and D. G. McMahon
Phase Resetting Light Pulses Induce Per1 and Persistent Spike Activity in a Subpopulation of Biological Clock Neurons
J. Neurosci., February 15, 2003; 23(4): 1441 - 1450.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. A. Tischkau, J. W. Mitchell, S.-H. Tyan, G. F. Buchanan, and M. U. Gillette
Ca2+/cAMP Response Element-binding Protein (CREB)-dependent Activation of Per1 Is Required for Light-induced Signaling in the Suprachiasmatic Nucleus Circadian Clock
J. Biol. Chem., January 3, 2003; 278(2): 718 - 723.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
S. Koyanagi and S. Ohdo
Alteration of Intrinsic Biological Rhythms during Interferon Treatment and Its Possible Mechanism
Mol. Pharmacol., December 1, 2002; 62(6): 1393 - 1399.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Hirota, T. Okano, K. Kokame, H. Shirotani-Ikejima, T. Miyata, and Y. Fukada
Glucose Down-regulates Per1 and Per2 mRNA Levels and Induces Circadian Gene Expression in Cultured Rat-1 Fibroblasts
J. Biol. Chem., November 8, 2002; 277(46): 44244 - 44251.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Y. Takanaka, T. Okano, K. Yamamoto, and Y. Fukada
A Negative Regulatory Element Required for Light-Dependent pinopsin Gene Expression
J. Neurosci., June 1, 2002; 22(11): 4357 - 4363.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Z. Travnickova-Bendova, N. Cermakian, S. M. Reppert, and P. Sassone-Corsi
Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK/BMAL1 activity
PNAS, May 28, 2002; 99(11): 7728 - 7733.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. E. Kolker, S. Losee Olson, J. Dutton-Boilek, K. M. Bennett, E. P. Wallen, T. H. Horton, and F. W. Turek
Feeding melatonin enhances the phase shifting response to triazolam in both young and old golden hamsters
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2002; 282(5): R1382 - R1388.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
R. Aida, T. Moriya, M. Araki, M. Akiyama, K. Wada, E. Wada, and S. Shibata
Gastrin-Releasing Peptide Mediates Photic Entrainable Signals to Dorsal Subsets of Suprachiasmatic Nucleus via Induction of Period Gene in Mice
Mol. Pharmacol., January 1, 2002; 61(1): 26 - 34.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. Takahashi, S.-i. Yokota, R. Hara, T. Kobayashi, M. Akiyama, T. Moriya, and S. Shibata
Physical and Inflammatory Stressors Elevate Circadian Clock Gene mPer1 mRNA Levels in the Paraventricular Nucleus of the Mouse
Endocrinology, November 1, 2001; 142(11): 4910 - 4917.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. Hamada, J. LeSauter, J. M. Venuti, and R. Silver
Expression of Period Genes: Rhythmic and Nonrhythmic Compartments of the Suprachiasmatic Nucleus Pacemaker
J. Neurosci., October 1, 2001; 21(19): 7742 - 7750.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. A. Prosser
Glutamate Blocks Serotonergic Phase Advances of the Mammalian Circadian Pacemaker through AMPA and NMDA Receptors
J. Neurosci., October 1, 2001; 21(19): 7815 - 7822.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
P. C. Yannielli and M. E. Harrington
The Neuropeptide Y Y5 Receptor Mediates the Blockade of "Photic-Like" NMDA-Induced Phase Shifts in the Golden Hamster
J. Neurosci., July 15, 2001; 21(14): 5367 - 5373.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. Hannibal, F. Jamen, H. S. Nielsen, L. Journot, P. Brabet, and J. Fahrenkrug
Dissociation between Light-Induced Phase Shift of the Circadian Rhythm and Clock Gene Expression in Mice Lacking the Pituitary Adenylate Cyclase Activating Polypeptide Type 1 Receptor
J. Neurosci., July 1, 2001; 21(13): 4883 - 4890.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Doi, Y. Nakajima, T. Okano, and Y. Fukada
Light-induced phase-delay of the chicken pineal circadian clock is associated with the induction of cE4bp4, a potential transcriptional repressor of cPer2 gene
PNAS, June 20, 2001; (2001) 141090998.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. A. Ferreyra and D. A. Golombek
Rhythmicity of the cGMP-related signal transduction pathway in the mammalian circadian system
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2001; 280(5): R1348 - R1355.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
T. Moriya, K. Horikawa, M. Akiyama, and S. Shibata
Correlative Association between N-Methyl-D-Aspartate Receptor-Mediated Expression of Period Genes in the Suprachiasmatic Nucleus and Phase Shifts in Behavior with Photic Entrainment of Clock in Hamsters
Mol. Pharmacol., April 13, 2001; 58(6): 1554 - 1562.
[Abstract] [Full Text]

Home page
 J. Neurosci.Home page
B. M. Steenhard and J. C. Besharse
Phase Shifting the Retinal Circadian Clock: xPer2 mRNA Induction by Light and Dopamine
J. Neurosci., December 1, 2000; 20(23): 8572 - 8577.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
H. O. de la, Iglesia, J. Meyer, A. Carpino Jr., and W. J. Schwartz
Antiphase Oscillation of the Left and Right Suprachiasmatic Nuclei
Science, October 27, 2000; 290(5492): 799 - 801.
[Abstract] [Full Text]

Home page
 J. Neurosci.Home page
T. Tamaru, Y. Isojima, T. Yamada, M. Okada, K. Nagai, and K. Takamatsu
Light and Glutamate-Induced Degradation of the Circadian Oscillating Protein BMAL1 during the Mammalian Clock Resetting
J. Neurosci., October 15, 2000; 20(20): 7525 - 7530.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. A. Tischkau, E. A. Gallman, G. F. Buchanan, and M. U. Gillette
Differential cAMP Gating of Glutamatergic Signaling Regulates Long-Term State Changes in the Suprachiasmatic Circadian Clock
J. Neurosci., October 15, 2000; 20(20): 7830 - 7837.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
L. P. Shearman, X. Jin, C. Lee, S. M. Reppert, and D. R. Weaver
Targeted Disruption of the mPer3 Gene: Subtle Effects on Circadian Clock Function
Mol. Cell. Biol., September 1, 2000; 20(17): 6269 - 6275.
[Abstract] [Full Text]

Home page
 Physiol. GenomicsHome page
I. EDERY
Circadian rhythms in a nutshell
Physiol Genomics, August 9, 2000; 3(2): 59 - 74.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
K. Horikawa, S.-i. Yokota, K. Fuji, M. Akiyama, T. Moriya, H. Okamura, and S. Shibata
Nonphotic Entrainment by 5-HT1A/7 Receptor Agonists Accompanied by Reduced Per1 and Per2 mRNA Levels in the Suprachiasmatic Nuclei
J. Neurosci., August 1, 2000; 20(15): 5867 - 5873.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
M. Akashi and E. Nishida
Involvement of the MAP kinase cascade in resetting of the mammalian circadian clock
Genes & Dev., March 15, 2000; 14(6): 645 - 649.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
E. S. Maywood, N. Mrosovsky, M. D. Field, and M. H. Hastings
Rapid down-regulation of mammalian Period genes during behavioral resetting of the circadian clock
PNAS, December 21, 1999; 96(26): 15211 - 15216.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. D. Wilsbacher, S. Yamazaki, E. D. Herzog, E.-J. Song, L. A. Radcliffe, M. Abe, G. Block, E. Spitznagel, M. Menaker, and J. S. Takahashi
Photic and circadian expression of luciferase in mPeriod1-luc transgenic mice invivo
PNAS, January 8, 2002; 99(1): 489 - 494.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Doi, Y. Nakajima, T. Okano, and Y. Fukada
Light-induced phase-delay of the chicken pineal circadian clock is associated with the induction of cE4bp4, a potential transcriptional repressor of cPer2 gene
PNAS, July 3, 2001; 98(14): 8089 - 8094.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. A. Tischkau, J. A. Barnes, F.-J. Lin, E. M. Myers, J. W. Soucy, E. L. Meyer-Bernstein, W. J. Hurst, P. W. Burgoon, D. Chen, A. Sehgal, et al.
Oscillation and Light Induction of timeless mRNA in the Mammalian Circadian Clock
J. Neurosci., June 15, 1999; 19(12): RC15 - RC15.
[Abstract] [Full Text] [PDF]


-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2008 by Society for Neuroscience ONLINE ISSN: 1529-2401
-