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The Journal of Neuroscience, February 15, 1999, 19(4):1257-1262
Ciliary Neurotrophic Factor is a Regulator of Muscular
Strength in Aging
Catherine
Guillet1,
Patrick
Auguste1,
Willy
Mayo2,
Paul
Kreher3, and
Hugues
Gascan1
1 Institut National de la Santé et de la
Recherche Médicale (INSERM) CJF 97-08, Centre Hospitalier
Universitaire Angers, 49033 Angers Cedex, France, 2 INSERM
U259, 33077 Bordeaux Cedex, France, and 3 Laboratoire de
Neurophysiologie, Centre National de la Recherche
Scientifique-EREA 120, 49045 Angers Cedex, France
Ciliary neurotrophic factor (CNTF) participates in the survival of
motor neurons and reduces the denervation-induced atrophy of skeletal
muscles. Experiments performed in rats show a decrease in peripheral
CNTF synthesis during aging, associated with an overexpression of its
 -binding receptor component by skeletal muscles. Measurement of
sciatic nerve CNTF production and of the muscular performance developed
by the animals revealed a strong correlation between the two studied
parameters (r = 0.8; p < 0.0003). Furthermore, the twitch and tetanic tensions measured in the
isolated soleus skeletal muscle in 24-month-old animals increased
2.5-fold by continuous in vivo administration of CNTF.
Analyses of the activation level of leukemia inhibitory factor receptor
 - and signal transducer and activator of transcription
3-signaling molecules in response to exogenous CNTF revealed an
increased tyrosine phosphorylation positively correlated with the
twitch tension developed by the soleus muscle of the animals.
Key words:
CNTF; CNTFR; aging; muscular strength; LIFR; STAT3
Copyright © 1999 Society for Neuroscience 0270-6474/99/1941257-06$05.00/0
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