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Next Article 
The Journal of Neuroscience, March 1, 1999, 19(5):1541-1556
Integrin Subunit Gene Expression Is Regionally Differentiated in
Adult Brain
Jason K.
Pinkstaff1,
Jon
Detterich1,
Gary
Lynch2, 3, and
Christine
Gall1
Departments of 1 Anatomy and Neurobiology,
2 Psychiatry and Human Behavior, and the
3 Center for the Neurobiology of Learning and Memory,
University of California at Irvine, Irvine, California 92697-1275
Integrins are a diverse family of heterodimeric (  ) adhesion
receptors recently shown to be concentrated within synapses and
involved in the consolidation of long-term potentiation. Whether neuronal types or anatomical systems in the adult rat brain are coded
by integrin type was studied in the present experiments by mapping the
relative densities of mRNAs for nine and four subunits.
Expression patterns were markedly different and in some regions
complementary. General results and areas of notable labeling were as
follows: 1 limited neuronal expression, neocortical layer V,
hippocampal CA3; 3 and 5diffuse neuronal and glial labeling,
Purkinje cells, hippocampal stratum pyramidale, locus coeruleus (3);
4 discrete limbic regions, olfactory cortical layer II,
hippocampal CA2; 6most prominently neuronal, neocortical subplate,
endopiriform, subiculum; 7discrete, all neocortical layers,
hippocampal granule cells and CA3, cerebellar granule and Purkinje
cells, all efferent cranial nerve nuclei; 8discrete neuronal, deep
cortex, hippocampal CA1, basolateral amygdala, striatum; Vall
cortical layers, striatum, Purkinje cells; 4dentate gyrus granule
cells; 5broadly distributed, neocortex, medial amygdala,
cerebellar granule and Purkinje cells, efferent cranial nerve nuclei;
2, 2, and 3mRNAs not detected. These results establish that
brain subfields express different balances of integrin subunits and
thus different integrin receptors. Such variations will determine which
matrix proteins are recognized by neurons and the types of
intraneuronal signaling generated by matrix binding. They also
could generate important differences in synaptic plasticity across
brain systems.
Key words:
adhesion molecules; extracellular matrix; hippocampus; cortex; brainstem; in situ hybridization
Copyright © 1999 Society for Neuroscience 0270-6474/99/1951541-16$05.00/0
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