 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, March 1, 1999, 19(5):1728-1735
Identification of the Kv2.1 K+ Channel as a Major Component of the Delayed Rectifier K+ Current in Rat Hippocampal Neurons
Hideyuki Murakoshi and James S. Trimmer Department of Biochemistry and Cell Biology and Institute for Cell and Developmental Biology, State University of New York, Stony Brook, New York 11794-5215
Molecular cloning studies have revealed the existence of a large family of voltage-gated K+ channel genes expressed in mammalian brain. This molecular diversity underlies the vast repertoire of neuronal K+ channels that regulate action potential conduction and neurotransmitter release and that are essential to the control of neuronal excitability. However, the specific contribution of individual K+ channel gene products to these neuronal K+ currents is poorly understood. We have shown previously, using an antibody, "KC," specific for the Kv2.1 K+ channel
-subunit, the high-level expression of Kv2.1 protein in hippocampal neurons in situ and in culture. Here we show that KC is a potent blocker of K+ currents expressed in cells transfected with the Kv2.1 cDNA, but not of currents expressed in cells transfected with other highly related K+ channel
Key words: ion channel; CNS; hippocampus; patch clamp; immunofluorescence; potassium current; neuronal excitability; epilepsy
Copyright © 1999 Society for Neuroscience 0270-6474/99/1951728-08$05.00/0
This article has been cited by other articles:
P. J. Mulholland, E. P. Carpenter-Hyland, M. C. Hearing, H. C. Becker, J. J. Woodward, and L. J. Chandler
Glutamate Transporters Regulate Extrasynaptic NMDA Receptor Modulation of Kv2.1 Potassium Channels
J. Neurosci., August 27, 2008; 28(35): 8801 - 8809.
[Abstract] [Full Text] [PDF]
H. Misonou, S. M. Thompson, and X. Cai
Dynamic Regulation of the Kv2.1 Voltage-Gated Potassium Channel during Brain Ischemia through Neuroglial Interaction
J. Neurosci., August 20, 2008; 28(34): 8529 - 8538.
[Abstract] [Full Text] [PDF]
D. P. Mohapatra, D. F. Siino, and J. S. Trimmer
Interdomain Cytoplasmic Interactions Govern the Intracellular Trafficking, Gating, and Modulation of the Kv2.1 Channel
J. Neurosci., May 7, 2008; 28(19): 4982 - 4994.
[Abstract] [Full Text] [PDF]
J. M. Nerbonne, B. R. Gerber, A. Norris, and A. Burkhalter
Electrical remodelling maintains firing properties in cortical pyramidal neurons lacking KCND2-encoded A-type K+ currents
J. Physiol., March 15, 2008; 586(6): 1565 - 1579.
[Abstract] [Full Text] [PDF]
D. P. Mohapatra, H. Vacher, and J. S. Trimmer
The Surprising Catch of a Voltage-Gated Potassium Channel in a Neuronal SNARE
Sci. Signal., July 3, 2007; 2007(393): pe37 - pe37.
[Abstract] [Full Text] [PDF]
D. Guan, T. Tkatch, D. J. Surmeier, W. E. Armstrong, and R. C. Foehring
Kv2 subunits underlie slowly inactivating potassium current in rat neocortical pyramidal neurons
J. Physiol., June 15, 2007; 581(3): 941 - 960.
[Abstract] [Full Text] [PDF]
A. H. Gittis and S. du Lac
Firing Properties of GABAergic Versus Non-GABAergic Vestibular Nucleus Neurons Conferred by a Differential Balance of Potassium Currents
J Neurophysiol, June 1, 2007; 97(6): 3986 - 3996.
[Abstract] [Full Text] [PDF]
P. T. Redman, K. He, K. A. Hartnett, B. S. Jefferson, L. Hu, P. A. Rosenberg, E. S. Levitan, and E. Aizenman
Apoptotic surge of potassium currents is mediated by p38 phosphorylation of Kv2.1
PNAS, February 27, 2007; 104(9): 3568 - 3573.
[Abstract] [Full Text] [PDF]
D. Singer-Lahat, A. Sheinin, D. Chikvashvili, S. Tsuk, D. Greitzer, R. Friedrich, L. Feinshreiber, U. Ashery, M. Benveniste, E. S. Levitan, et al.
K+ Channel Facilitation of Exocytosis by Dynamic Interaction with Syntaxin
J. Neurosci., February 14, 2007; 27(7): 1651 - 1658.
[Abstract] [Full Text] [PDF]
H. Misonou, M. Menegola, D. P. Mohapatra, L. K. Guy, K.-S. Park, and J. S. Trimmer
Bidirectional Activity-Dependent Regulation of Neuronal Ion Channel Phosphorylation
J. Neurosci., December 27, 2006; 26(52): 13505 - 13514.
[Abstract] [Full Text] [PDF]
D. J. Schulz, R. A. Baines, C. M. Hempel, L. Li, B. Liss, and H. Misonou
Cellular Excitability and the Regulation of Functional Neuronal Identity: From Gene Expression to Neuromodulation
J. Neurosci., October 11, 2006; 26(41): 10362 - 10367.
[Full Text] [PDF]
K.-S. Park, D. P. Mohapatra, H. Misonou, and J. S. Trimmer
Graded regulation of the Kv2.1 potassium channel by variable phosphorylation.
Science, August 18, 2006; 313(5789): 976 - 979.
[Abstract] [Full Text] [PDF]
J. G. Trapani, P. Andalib, J. F. Consiglio, and S. J. Korn
Control of Single Channel Conductance in the Outer Vestibule of the Kv2.1 Potassium Channel
J. Gen. Physiol., July 31, 2006; 128(2): 231 - 246.
[Abstract] [Full Text] [PDF]
D. P. Mohapatra and J. S. Trimmer
The Kv2.1 C Terminus Can Autonomously Transfer Kv2.1-Like Phosphorylation-Dependent Localization, Voltage-Dependent Gating, and Muscarinic Modulation to Diverse Kv Channels
J. Neurosci., January 11, 2006; 26(2): 685 - 695.
[Abstract] [Full Text] [PDF]
H. Misonou, D. P. Mohapatra, M. Menegola, and J. S. Trimmer
Calcium- and Metabolic State-Dependent Modulation of the Voltage-Dependent Kv2.1 Channel Regulates Neuronal Excitability in Response to Ischemia
J. Neurosci., November 30, 2005; 25(48): 11184 - 11193.
[Abstract] [Full Text] [PDF]
M. A. Ariano, C. Cepeda, C. R. Calvert, J. Flores-Hernandez, E. Hernandez-Echeagaray, G. J. Klapstein, S. H. Chandler, N. Aronin, M. DiFiglia, and M. S. Levine
Striatal Potassium Channel Dysfunction in Huntington's Disease Transgenic Mice
J Neurophysiol, May 1, 2005; 93(5): 2565 - 2574.
[Abstract] [Full Text] [PDF]
M. L Dallas, L. Atkinson, C. J Milligan, N. P Morris, D. I Lewis, S. A Deuchars, and J. Deuchars
Localization and function of the Kv3.1b subunit in the rat medulla oblongata: focus on the nucleus tractus solitarii
J. Physiol., February 1, 2005; 562(3): 655 - 672.
[Abstract] [Full Text] [PDF]
X. Chen and D. Johnston
Properties of single voltage-dependent K+ channels in dendrites of CA1 pyramidal neurones of rat hippocampus
J. Physiol., August 15, 2004; 559(1): 187 - 203.
[Abstract] [Full Text] [PDF]
E. A. L. Muennich and R. E. W. Fyffe
Focal aggregation of voltage-gated, Kv2.1 subunit-containing, potassium channels at synaptic sites in rat spinal motoneurones
J. Physiol., February 1, 2004; 554(3): 673 - 685.
[Abstract] [Full Text] [PDF]
Z. A. McCrossan, A. Lewis, G. Panaghie, P. N. Jordan, D. J. Christini, D. J. Lerner, and G. W. Abbott
MinK-Related Peptide 2 Modulates Kv2.1 and Kv3.1 Potassium Channels in Mammalian Brain
J. Neurosci., September 3, 2003; 23(22): 8077 - 8091.
[Abstract] [Full Text] [PDF]
S. Pal, K. A. Hartnett, J. M. Nerbonne, E. S. Levitan, and E. Aizenman
Mediation of Neuronal Apoptosis by Kv2.1-Encoded Potassium Channels
J. Neurosci., June 15, 2003; 23(12): 4798 - 4802.
[Abstract] [Full Text] [PDF]
Y. Dong and F. J. White
Dopamine D1-Class Receptors Selectively Modulate a Slowly Inactivating Potassium Current in Rat Medial Prefrontal Cortex Pyramidal Neurons
J. Neurosci., April 1, 2003; 23(7): 2686 - 2695.
[Abstract] [Full Text] [PDF]
S. A. Malin and J. M. Nerbonne
Delayed Rectifier K+ Currents, IK, Are Encoded by Kv2 alpha -Subunits and Regulate Tonic Firing in Mammalian Sympathetic Neurons
J. Neurosci., December 1, 2002; 22(23): 10094 - 10105.
[Abstract] [Full Text] [PDF]
J. Mitterdorfer and B. P. Bean
Potassium Currents during the Action Potential of Hippocampal CA3 Neurons
J. Neurosci., December 1, 2002; 22(23): 10106 - 10115.
[Abstract] [Full Text] [PDF]
P. Andalib, M. J. Wood, and S. J. Korn
Control of Outer Vestibule Dynamics and Current Magnitude in the Kv2.1 Potassium Channel
J. Gen. Physiol., October 29, 2002; 120(5): 739 - 755.
[Abstract] [Full Text] [PDF]
P. Escoubas, S. Diochot, M.-L. Celerier, T. Nakajima, and M. Lazdunski
Novel Tarantula Toxins for Subtypes of Voltage-Dependent Potassium Channels in the Kv2 and Kv4 Subfamilies
Mol. Pharmacol., July 1, 2002; 62(1): 48 - 57.
[Abstract] [Full Text] [PDF]
N. Ottschytsch, A. Raes, D. Van Hoorick, and D. J. Snyders
Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha -subunits identified in the human genome
PNAS, June 11, 2002; 99(12): 7986 - 7991.
[Abstract] [Full Text] [PDF]
W. Muller and K. Bittner
Differential Oxidative Modulation of Voltage-Dependent K+ Currents in Rat Hippocampal Neurons
J Neurophysiol, June 1, 2002; 87(6): 2990 - 2995.
[Abstract] [Full Text] [PDF]
C. R. Campomanes, K. I. Carroll, L. N. Manganas, M. E. Hershberger, B. Gong, D. E. Antonucci, K. J. Rhodes, and J. S. Trimmer
Kvbeta Subunit Oxidoreductase Activity and Kv1 Potassium Channel Trafficking
J. Biol. Chem., March 1, 2002; 277(10): 8298 - 8305.
[Abstract] [Full Text] [PDF]
L. N. Manganas, Q. Wang, R. H. Scannevin, D. E. Antonucci, K. J. Rhodes, and J. S. Trimmer
Identification of a trafficking determinant localized to the Kv1 potassium channel pore
PNAS, October 31, 2001; (2001) 241403898.
[Abstract] [Full Text] [PDF]
P. A. Castro, E. C. Cooper, D. H. Lowenstein, and S. C. Baraban
Hippocampal Heterotopia Lack Functional Kv4.2 Potassium Channels in the Methylazoxymethanol Model of Cortical Malformations and Epilepsy
J. Neurosci., September 1, 2001; 21(17): 6626 - 6634.
[Abstract] [Full Text] [PDF]
J. T. Blaine and A. B. Ribera
Kv2 Channels Form Delayed-Rectifier Potassium Channels In Situ
J. Neurosci., March 1, 2001; 21(5): 1473 - 1480.
[Abstract] [Full Text] [PDF]
J. Kang, J. R. Huguenard, and D. A. Prince
Voltage-Gated Potassium Channels Activated During Action Potentials in Layer V Neocortical Pyramidal Neurons
J Neurophysiol, January 1, 2000; 83(1): 70 - 80.
[Abstract] [Full Text] [PDF]
S. Vassanelli and P. Fromherz
Transistor Probes Local Potassium Conductances in the Adhesion Region of Cultured Rat Hippocampal Neurons
J. Neurosci., August 15, 1999; 19(16): 6767 - 6773.
[Abstract] [Full Text] [PDF]
M. D. Chiara, F. Monje, A. Castellano, and J. Lopez-Barneo
A Small Domain in the N Terminus of the Regulatory alpha -Subunit Kv2.3 Modulates Kv2.1 Potassium Channel Gating
J. Neurosci., August 15, 1999; 19(16): 6865 - 6873.
[Abstract] [Full Text] [PDF]
F. Ono, Y. Katsuyama, K. Nakajo, and Y. Okamura
Subfamily-Specific Posttranscriptional Mechanism Underlies K+ Channel Expression in a Developing Neuronal Blastomere
J. Neurosci., August 15, 1999; 19(16): 6874 - 6886.
[Abstract] [Full Text] [PDF]
G. Baranauskas, T. Tkatch, and D. J. Surmeier
Delayed Rectifier Currents in Rat Globus Pallidus Neurons Are Attributable to Kv2.1 and Kv3.1/3.2 K+ Channels
J. Neurosci., August 1, 1999; 19(15): 6394 - 6404.
[Abstract] [Full Text] [PDF]
N. P. Poolos and D. Johnston
Calcium-Activated Potassium Conductances Contribute to Action Potential Repolarization at the Soma But Not the Dendrites of Hippocampal CA1 Pyramidal Neurons
J. Neurosci., July 1, 1999; 19(13): 5205 - 5212.
[Abstract] [Full Text] [PDF]
L. N. Manganas and J. S. Trimmer
Subunit Composition Determines Kv1 Potassium Channel Surface Expression
J. Biol. Chem., September 15, 2000; 275(38): 29685 - 29693.
[Abstract] [Full Text] [PDF]
L. N. Manganas, Q. Wang, R. H. Scannevin, D. E. Antonucci, K. J. Rhodes, and J. S. Trimmer
Identification of a trafficking determinant localized to the Kv1 potassium channel pore
PNAS, November 20, 2001; 98(24): 14055 - 14059.
[Abstract] [Full Text] [PDF]
B. London, W. Guo, X.-h. Pan, J. S. Lee, V. Shusterman, C. J. Rocco, D. A. Logothetis, J. M. Nerbonne, and J. A. Hill
Targeted Replacement of Kv1.5 in the Mouse Leads to Loss of the 4-Aminopyridine-Sensitive Component of IK,slow and Resistance to Drug-Induced QT Prolongation
Circ. Res., May 11, 2001; 88(9): 940 - 946.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|