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The Journal of Neuroscience, March 1, 1999, 19(5):1782-1803
Cerebellar Purkinje Cell Simple Spike Discharge Encodes Movement
Velocity in Primates during Visuomotor Arm Tracking
J. D.
Coltz1,
M. T. V.
Johnson4, and
T. J.
Ebner1, 2, 3, 4
1 Graduate Program in Neuroscience and Departments of
2 Neuroscience, 3 Physiology, and
4 Neurosurgery, University of Minnesota, Minneapolis
Minnesota 55455
Pathophysiological, lesion, and electrophysiological studies
suggest that the cerebellar cortex is important for controlling the
direction and speed of movement. The relationship of cerebellar Purkinje cell discharge to the control of arm movement parameters, however, remains unclear. The goal of this study was to examine how
movement direction and speed and their interaction velocitymodulate Purkinje cell simple spike discharge in an arm movement task in which
direction and speed were independently controlled. The simple spike
discharge of 154 Purkinje cells was recorded in two monkeys during the
performance of two visuomotor tasks that required the animals to track
targets that moved in one of eight directions and at one of four
speeds. Single-parameter regression analyses revealed that a large
proportion of cells had discharge modulation related to movement
direction and speed. Most cells with significant directional tuning,
however, were modulated at one speed, and most cells with speed-related
discharge were modulated along one direction; this suggested that the
patterns of simple spike discharge were not adequately described by
single-parameter models. Therefore, a regression surface was fitted to
the data, which showed that the discharge could be tuned to specific
direction-speed combinations (preferred velocities). The overall
variability in simple spike discharge was well described by the surface
model, and the velocities corresponding to maximal and minimal
discharge rates were distributed uniformly throughout the workspace.
Simple spike discharge therefore appears to integrate information about
both the direction and speed of arm movements, thereby encoding
movement velocity.
Key words:
cerebellum; simple spike; direction; speed; velocity; primate; arm; tracking
Copyright © 1999 Society for Neuroscience 0270-6474/99/1951782-22$05.00/0
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