QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (29) Citing Articles via Google Scholar Google Scholar Articles by Sallmen, T. Articles by Panula, P. Search for Related Content PubMed PubMed Citation Articles by Sallmen, T. Articles by Panula, P.

 Previous Article  |  Next Article 

The Journal of Neuroscience, March 1, 1999, 19(5):1824-1835

Major Changes in the Brain Histamine System of the Ground Squirrel Citellus lateralis during Hibernation

Tina Sallmen¹, Alexander L. Beckman², Toni L. Stanton³, Krister S. Eriksson¹, Juhani Tarhanen⁴, Leena Tuomisto⁵, and Pertti Panula¹

¹ Department of Biology, Åbo Akademi University, Åbo/Turku, Finland, Departments of ² Psychology, and ³ Biological Sciences, California State University, Long Beach, California, and Departments of ⁴ Environmental Sciences, and ⁵ Pharmacology and Toxicology, University of Kuopio, Kuopio, Finland

Hibernation in mammals such as the rodent hibernator Citellus lateralis is a physiological state in which CNS activity is endogenously maintained at a very low, but functionally responsive, level. The neurotransmitter histamine is involved in the regulation of diurnal rhythms and body temperature in nonhibernators and, therefore, could likely play an important role in maintaining the hibernating state. In this study, we show that histamine neuronal systems undergo major changes during hibernation that are consistent with such a role. Immunohistochemical mapping of histaminergic fibers in the brains of hibernating and nonhibernating golden-mantled ground squirrels (C. lateralis) showed a clear increase in fiber density during the hibernating state. The tissue levels of histamine and its first metabolite tele-methylhistamine were also elevated throughout the brain of hibernating animals, suggesting an increase in histamine turnover during hibernation, which occurs without an increase in histidine decarboxylase mRNA expression. This hibernation-related apparent augmentation of histaminergic neurotransmission was particularly evident in the hypothalamus and hippocampus, areas of importance to the control of the hibernating state, in which tele-methylhistamine levels were increased more than threefold. These changes in the histamine neuronal system differ from those reported for the metabolic pattern in other monoaminergic systems during hibernation, which generally indicate a decrease in turnover. Our results suggest that the influence of histamine neuronal systems may be important in controlling CNS activity during hibernation.

Key words: hibernation; CNS; hippocampus; hypothalamus; preoptic area; septum; histamine; tele-methylhistamine; monoamine

---

Copyright © 1999 Society for Neuroscience  0270-6474/99/1951824-12$05.00/0

This article has been cited by other articles:

				H. L. Haas, O. A. Sergeeva, and O. Selbach Histamine in the Nervous System Physiol Rev, July 1, 2008; 88(3): 1183 - 1241. [Abstract] [Full Text] [PDF]

				P. Barrett, A. W. Ross, A. Balik, P. A. Littlewood, J. G. Mercer, K. M. Moar, T. Sallmen, J. Kaslin, P. Panula, S. Schuhler, et al. Photoperiodic Regulation of Histamine H3 Receptor and VGF Messenger Ribonucleic Acid in the Arcuate Nucleus of the Siberian Hamster Endocrinology, April 1, 2005; 146(4): 1930 - 1939. [Abstract] [Full Text] [PDF]

				A. W. Ross, L. M. Bell, P. A. Littlewood, J. G. Mercer, P. Barrett, and P. J. Morgan Temporal Changes in Gene Expression in the Arcuate Nucleus Precede Seasonal Responses in Adiposity and Reproduction Endocrinology, April 1, 2005; 146(4): 1940 - 1947. [Abstract] [Full Text] [PDF]

				C. Xu, K. A Michelsen, M. Wu, E. Morozova, P. Panula, and M. Alreja Histamine innervation and activation of septohippocampal GABAergic neurones: involvement of local ACh release J. Physiol., December 15, 2004; 561(3): 657 - 670. [Abstract] [Full Text] [PDF]

				H. V. CAREY, M. T. ANDREWS, and S. L. MARTIN Mammalian Hibernation: Cellular and Molecular Responses to Depressed Metabolism and Low Temperature Physiol Rev, October 1, 2003; 83(4): 1153 - 1181. [Abstract] [Full Text] [PDF]

				G. Drutel, N. Peitsaro, K. Karlstedt, K. Wieland, M. J. Smit, H. Timmerman, P. Panula, and R. Leurs Identification of Rat H3 Receptor Isoforms with Different Brain Expression and Signaling Properties Mol. Pharmacol., January 1, 2001; 59(1): 1 - 8. [Abstract] [Full Text]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help