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Next Article 
The Journal of Neuroscience, March 15, 1999, 19(6):1895-1911
Differential Distribution of Three Members of a Gene Family
Encoding Low Voltage-Activated (T-Type) Calcium Channels
Edmund M.
Talley1,
Leanne L.
Cribbs2,
Jung-Ha
Lee2,
Asif
Daud2,
Edward
Perez-Reyes2, and
Douglas A.
Bayliss1
1 Department of Pharmacology, University of Virginia,
Charlottesville, Virginia 22908, and 2 Department of
Physiology, Loyola University Medical Center, Maywood, Illinois 60153
Low voltage-activated (T-type) calcium currents are observed in
many central and peripheral neurons and display distinct physiological and functional properties. Using in situ hybridization,
we have localized central and peripheral nervous system expression of three transcripts ( 1G, 1H, and 1I) of the T-type calcium
channel family (CaVT). Each mRNA demonstrated a unique
distribution, and expression of the three genes was largely
complementary. We found high levels of expression of these transcripts
in regions associated with prominent T-type currents, including
inferior olivary and thalamic relay neurons (which expressed 1G),
sensory ganglia, pituitary, and dentate gyrus granule neurons ( 1H),
and thalamic reticular neurons ( 1I and 1H). Other regions of high
expression included the Purkinje cell layer of the cerebellum, the bed
nucleus of the stria terminalis, the claustrum ( 1G), the olfactory
tubercles ( 1H and 1I), and the subthalamic nucleus ( 1I and
1G). Some neurons expressed high levels of all three genes,
including hippocampal pyramidal neurons and olfactory granule cells.
Many brain regions showed a predominance of labeling for 1G,
including the amygdala, cerebral cortex, rostral hypothalamus,
brainstem, and spinal cord. Exceptions included the basal ganglia,
which showed more prominent labeling for 1H and 1I, and the
olfactory bulb, the hippocampus, and the caudal hypothalamus, which
showed more even levels of all three transcripts. Our results are
consistent with the hypothesis that differential gene expression
underlies pharmacological and physiological heterogeneity observed in
neuronal T-type calcium currents, and they provide a molecular basis
for the study of T-type channels in particular neurons.
Key words:
in situ hybridization; calcium channel; CNS; anticonvulsant; rat; T-type calcium channels
Copyright © 1999 Society for Neuroscience 0270-6474/99/1961895-17$05.00/0
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December 1, 2004;
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1310 - 1327.
[Abstract]
[Full Text]
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C. S. Chan, R. Shigemoto, J. N. Mercer, and D. J. Surmeier
HCN2 and HCN1 Channels Govern the Regularity of Autonomous Pacemaking and Synaptic Resetting in Globus Pallidus Neurons
J. Neurosci.,
November 3, 2004;
24(44):
9921 - 9932.
[Abstract]
[Full Text]
[PDF]
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Y.-Q. Yu, Y. Xiong, Y.-S. Chan, and J. He
In vivo intracellular responses of the medial geniculate neurones to acoustic stimuli in anaesthetized guinea pigs
J. Physiol.,
October 1, 2004;
560(1):
191 - 205.
[Abstract]
[Full Text]
[PDF]
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A. Agoston, L. Kunz, A. Krieger, and A. Mayerhofer
Two Types of Calcium Channels in Human Ovarian Endocrine Cells: Involvement in Steroidogenesis
J. Clin. Endocrinol. Metab.,
September 1, 2004;
89(9):
4503 - 4512.
[Abstract]
[Full Text]
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N. Leresche, J. Hering, and R. C. Lambert
Paradoxical Potentiation of Neuronal T-Type Ca2+ Current by ATP at Resting Membrane Potential
J. Neurosci.,
June 16, 2004;
24(24):
5592 - 5602.
[Abstract]
[Full Text]
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Y. Zhang, A. P. Vilaythong, D. Yoshor, and J. L. Noebels
Elevated Thalamic Low-Voltage-Activated Currents Precede the Onset of Absence Epilepsy in the SNAP25-Deficient Mouse Mutant Coloboma
J. Neurosci.,
June 2, 2004;
24(22):
5239 - 5248.
[Abstract]
[Full Text]
[PDF]
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I. Song, D. Kim, S. Choi, M. Sun, Y. Kim, and H.-S. Shin
Role of the {alpha}1G T-Type Calcium Channel in Spontaneous Absence Seizures in Mutant Mice
J. Neurosci.,
June 2, 2004;
24(22):
5249 - 5257.
[Abstract]
[Full Text]
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H. Khosravani, C. Altier, B. Simms, K. S. Hamming, T. P. Snutch, J. Mezeyova, J. E. McRory, and G. W. Zamponi
Gating Effects of Mutations in the Cav3.2 T-type Calcium Channel Associated with Childhood Absence Epilepsy
J. Biol. Chem.,
March 12, 2004;
279(11):
9681 - 9684.
[Abstract]
[Full Text]
[PDF]
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E. Perez-Reyes
Paradoxical Role of T-type Calcium Channels in Coronary Smooth Muscle
Mol. Interv.,
February 1, 2004;
4(1):
16 - 18.
[Abstract]
[Full Text]
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C.-C. Chen, K. G. Lamping, D. W. Nuno, R. Barresi, S. J. Prouty, J. L. Lavoie, L. L. Cribbs, S. K. England, C. D. Sigmund, R. M. Weiss, et al.
Abnormal Coronary Function in Mice Deficient in {alpha}1H T-type Ca2+ Channels
Science,
November 21, 2003;
302(5649):
1416 - 1418.
[Abstract]
[Full Text]
[PDF]
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H. Shan, M. L. Messi, Z. Zheng, Z.-M. Wang, and O. Delbono
Preservation of motor neuron Ca2+ channel sensitivity to insulin-like growth factor-1 in brain motor cortex from senescent rat
J. Physiol.,
November 15, 2003;
553(1):
49 - 63.
[Abstract]
[Full Text]
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P. J. Welsby, H. Wang, J. T. Wolfe, R. J. Colbran, M. L. Johnson, and P. Q. Barrett
A Mechanism for the Direct Regulation of T-Type Calcium Channels by Ca2+/Calmodulin-Dependent Kinase II
J. Neurosci.,
November 5, 2003;
23(31):
10116 - 10121.
[Abstract]
[Full Text]
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G. Pinato and J. Midtgaard
Regulation of Granule Cell Excitability by a Low-Threshold Calcium Spike in Turtle Olfactory Bulb
J Neurophysiol,
November 1, 2003;
90(5):
3341 - 3351.
[Abstract]
[Full Text]
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A. M. Swensen and B. P. Bean
Ionic Mechanisms of Burst Firing in Dissociated Purkinje Neurons
J. Neurosci.,
October 22, 2003;
23(29):
9650 - 9663.
[Abstract]
[Full Text]
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D. Kim, D. Park, S. Choi, S. Lee, M. Sun, C. Kim, and H.-S. Shin
Thalamic Control of Visceral Nociception Mediated by T-Type Ca2+ Channels
Science,
October 3, 2003;
302(5642):
117 - 119.
[Abstract]
[Full Text]
[PDF]
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A. DESTEXHE and T. J. SEJNOWSKI
Interactions Between Membrane Conductances Underlying Thalamocortical Slow-Wave Oscillations
Physiol Rev,
October 1, 2003;
83(4):
1401 - 1453.
[Abstract]
[Full Text]
[PDF]
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J. Mu, W. B. Carden, N. C. Kurukulasuriya, G. M. Alexander, and D. W. Godwin
Ethanol Influences on Native T-Type Calcium Current in Thalamic Sleep Circuitry
J. Pharmacol. Exp. Ther.,
October 1, 2003;
307(1):
197 - 204.
[Abstract]
[Full Text]
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V. Egger, K. Svoboda, and Z. F. Mainen
Mechanisms of Lateral Inhibition in the Olfactory Bulb: Efficiency and Modulation of Spike-Evoked Calcium Influx into Granule Cells
J. Neurosci.,
August 20, 2003;
23(20):
7551 - 7558.
[Abstract]
[Full Text]
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A. T. Schaefer, M. E. Larkum, B. Sakmann, and A. Roth
Coincidence Detection in Pyramidal Neurons Is Tuned by Their Dendritic Branching Pattern
J Neurophysiol,
June 1, 2003;
89(6):
3143 - 3154.
[Abstract]
[Full Text]
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M. Russier, E. Carlier, N. Ankri, L. Fronzaroli, and D. Debanne
A-, T-, and H-type Currents Shape Intrinsic Firing of Developing Rat Abducens Motoneurons
J. Physiol.,
May 15, 2003;
549(1):
21 - 36.
[Abstract]
[Full Text]
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R. K. Cloues and W. A. Sather
Afterhyperpolarization Regulates Firing Rate in Neurons of the Suprachiasmatic Nucleus
J. Neurosci.,
March 1, 2003;
23(5):
1593 - 1604.
[Abstract]
[Full Text]
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D. M. Porcello, S. D. Smith, and J. R. Huguenard
Actions of U-92032, a T-Type Ca2+ Channel Antagonist, Support a Functional Linkage Between IT and Slow Intrathalamic Rhythms
J Neurophysiol,
January 1, 2003;
89(1):
177 - 185.
[Abstract]
[Full Text]
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E. Perez-Reyes
Molecular Physiology of Low-Voltage-Activated T-type Calcium Channels
Physiol Rev,
January 1, 2003;
83(1):
117 - 161.
[Abstract]
[Full Text]
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J. Chemin, J. Nargeot, and P. Lory
Neuronal T-type alpha 1H Calcium Channels Induce Neuritogenesis and Expression of High-Voltage-Activated Calcium Channels in the NG108-15 Cell Line
J. Neurosci.,
August 15, 2002;
22(16):
6856 - 6862.
[Abstract]
[Full Text]
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Y. Zhang, M. Mori, D. L. Burgess, and J. L. Noebels
Mutations in High-Voltage-Activated Calcium Channel Genes Stimulate Low-Voltage-Activated Currents in Mouse Thalamic Relay Neurons
J. Neurosci.,
August 1, 2002;
22(15):
6362 - 6371.
[Abstract]
[Full Text]
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K. Hirooka, G. E. Bertolesi, M. E. M. Kelly, E. M. Denovan-Wright, X. Sun, J. Hamid, G. W. Zamponi, A. E. Juhasz, L. W. Haynes, and S. Barnes
T-Type Calcium Channel alpha 1G and alpha 1H Subunits in Human Retinoblastoma Cells and Their Loss After Differentiation
J Neurophysiol,
July 1, 2002;
88(1):
196 - 205.
[Abstract]
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J.-H. Lee, E.-G. Kim, B.-G. Park, K.-H. Kim, S.-K. Cha, I. D. Kong, J.-W. Lee, and S.-W. Jeong
Identification of T-Type alpha 1H Ca2+ Channels (Cav3.2) in Major Pelvic Ganglion Neurons
J Neurophysiol,
June 1, 2002;
87(6):
2844 - 2850.
[Abstract]
[Full Text]
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J. Wolfart and J. Roeper
Selective Coupling of T-Type Calcium Channels to SK Potassium Channels Prevents Intrinsic Bursting in Dopaminergic Midbrain Neurons
J. Neurosci.,
May 1, 2002;
22(9):
3404 - 3413.
[Abstract]
[Full Text]
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H. Su, D. Sochivko, A. Becker, J. Chen, Y. Jiang, Y. Yaari, and H. Beck
Upregulation of a T-Type Ca2+ Channel Causes a Long-Lasting Modification of Neuronal Firing Mode after Status Epilepticus
J. Neurosci.,
May 1, 2002;
22(9):
3645 - 3655.
[Abstract]
[Full Text]
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J. Chemin, A. Monteil, E. Perez-Reyes, E. Bourinet, J. Nargeot, and P. Lory
Specific contribution of human T-type calcium channel isotypes ({alpha}1G, {alpha}1H and {alpha}1I) to neuronal excitability
J. Physiol.,
April 1, 2002;
540(1):
3 - 14.
[Abstract]
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C. J. Frazier, J. R. Serrano, E. G. George, X. Yu, A. Viswanathan, E. Perez-Reyes, and S. W. Jones
Gating Kinetics of the {alpha}1i T-Type Calcium Channel
J. Gen. Physiol.,
November 1, 2001;
118(5):
457 - 470.
[Abstract]
[Full Text]
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J. C. Gomora, A. N. Daud, M. Weiergraber, and E. Perez-Reyes
Block of Cloned Human T-Type Calcium Channels by Succinimide Antiepileptic Drugs
Mol. Pharmacol.,
November 1, 2001;
60(5):
1121 - 1132.
[Abstract]
[Full Text]
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O. Lesouhaitier, A. Chiappe, and M. F. Rossier
Aldosterone Increases T-Type Calcium Currents in Human Adrenocarcinoma (H295R) Cells by Inducing Channel Expression
Endocrinology,
October 1, 2001;
142(10):
4320 - 4330.
[Abstract]
[Full Text]
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S. M. Todorovic, V. Jevtovic-Todorovic, S. Mennerick, E. Perez-Reyes, and C. F. Zorumski
Cav3.2 Channel Is a Molecular Substrate for Inhibition of T-Type Calcium Currents in Rat Sensory Neurons by Nitrous Oxide
Mol. Pharmacol.,
September 1, 2001;
60(3):
603 - 610.
[Abstract]
[Full Text]
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S.-N. YANG, J. YU, G. W. MAYR, F. HOFMANN, O. LARSSON, and P.-O. BERGGREN
Inositol hexakisphosphate increases L-type Ca2+ channel activity by stimulation of adenylyl cyclase
FASEB J,
August 1, 2001;
15(10):
1753 - 1763.
[Abstract]
[Full Text]
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M. Ito
Cerebellar Long-Term Depression: Characterization, Signal Transduction, and Functional Roles
Physiol Rev,
July 1, 2001;
81(3):
1143 - 1195.
[Abstract]
[Full Text]
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P J Green, R Warre, P D Hayes, N C L McNaughton, A D Medhurst, M Pangalos, D M Duckworth, and A D Randall
Kinetic modification of the {alpha}1I subunit-mediated T-type Ca2+ channel by a human neuronal Ca2+ channel {gamma} subunit
J. Physiol.,
June 1, 2001;
533(2):
467 - 478.
[Abstract]
[Full Text]
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S. Brevi, M. de Curtis, and J. Magistretti
Pharmacological and Biophysical Characterization of Voltage-Gated Calcium Currents in the Endopiriform Nucleus of the Guinea Pig
J Neurophysiol,
May 1, 2001;
85(5):
2076 - 2087.
[Abstract]
[Full Text]
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Q.-Q. Sun, J. R Huguenard, and D. A Prince
Neuropeptide Y receptors differentially modulate G-protein-activated inwardly rectifying K+ channels and high-voltage-activated Ca2+ channels in rat thalamic neurons
J. Physiol.,
February 15, 2001;
531(1):
67 - 79.
[Abstract]
[Full Text]
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A. D. Schrier, H. Wang, E. M. Talley, E. Perez-Reyes, and P. Q. Barrett
{alpha}1H T-type Ca2+ channel is the predominant subtype expressed in bovine and rat zona glomerulosa
Am J Physiol Cell Physiol,
February 1, 2001;
280(2):
C265 - C272.
[Abstract]
[Full Text]
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R. C. Foehring, P. G. Mermelstein, W.-J. Song, S. Ulrich, and D. J. Surmeier
Unique Properties of R-Type Calcium Currents in Neocortical and Neostriatal Neurons
J Neurophysiol,
November 1, 2000;
84(5):
2225 - 2236.
[Abstract]
[Full Text]
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W.-J. Song, Y. Baba, T. Otsuka, and F. Murakami
Characterization of Ca2+ Channels in Rat Subthalamic Nucleus Neurons
J Neurophysiol,
November 1, 2000;
84(5):
2630 - 2637.
[Abstract]
[Full Text]
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