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The Journal of Neuroscience, March 15, 1999, 19(6):1952-1958

Distinct Signaling Pathways Mediate Touch and Osmosensory Responses in a Polymodal Sensory Neuron

Anne C. Hart1, 2, Jamie Kass3, Jonathan E. Shapiro2, and Joshua M. Kaplan4

1 Department of Pathology, Harvard Medical School, and 2 Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts 02129, 3 Department of Genetics, Harvard Medical School, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, and 4 Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3200

The Caenorhabditis elegans ASH sensory neurons mediate responses to nose touch, hyperosmolarity, and volatile repellent chemicals. We show here that distinct signaling pathways mediate the responses to touch and hyperosmolarity. ASH neurons distinguish between these stimuli because habituation to nose touch has no effect on the response to high osmolarity or volatile chemicals (1-octanol). Mutations in osm-10 eliminate the response to hyperosmolarity but have no effect on responses to nose touch or to volatile repellents. OSM-10 is a novel cytosolic protein expressed in ASH and three other classes of sensory neurons. Mutations in two other osmosensory-defective genes, eos-1 and eos-2, interact genetically with osm-10. Our analysis suggests that nose touch sensitivity and osmosensation occur via distinct signaling pathways in ASH and that OSM-10 is required for osmosensory signaling.

Key words: Caenorhabditis elegans; osmosensation; mechanosensation; neurodegeneration; OSM-10; eos-1; eos-2; degenerin

Copyright © 1999 Society for Neuroscience  0270-6474/99/1961952-07$05.00/0


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