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The Journal of Neuroscience, March 15, 1999, 19(6):2122-2130
Brain-Derived Neurotrophic Factor Prevents Low-Frequency
Inputs from Inducing Long-Term Depression in the Developing Visual
Cortex
Shuichiro
Kinoshita1,
Hiroki
Yasuda1,
Nobuaki
Taniguchi1,
Ritsuko
Katoh-Semba2,
Hiroshi
Hatanaka3, and
Tadaharu
Tsumoto1
1 Department of Neurophysiology, Biomedical Research
Center, Osaka University Medical School, Suita, 565-0871 Japan,
2 Institute for Developmental Research, Aichi Human Service
Center, Kasugai, Aichi 480-0392 Japan, and 3 Division of
Protein Biosynthesis, Institute for Protein Research, Osaka University,
Suita, 565-0871 Japan
Brain-derived neurotrophic factor (BDNF) is reported to enhance
synaptic transmission and to play a role in long-term potentiation in
hippocampus and neocortex. If so, a shortage or blockade of BDNF might
lead to another form of synaptic plasticity, long-term depression
(LTD). To test this possibility and to elucidate mechanisms if it is
the case, EPSCs evoked by test stimulation of layer IV were
recorded from layer II/III neurons in visual cortical slices of young
rats in the whole-cell voltage-clamp mode. LTD was induced by
low-frequency stimulation (LFS) at 1 Hz for 10-15 min if each pulse of
the LFS was paired with depolarization of neurons to  30 mV but was
not induced if their membrane potentials were kept at 70 mV. Such an
LTD was blocked by exogenously applied BDNF, probably through
presynaptic mechanisms. Suppression of endogenous BDNF activity by the
anti-BDNF antibody or an inhibitor for BDNF receptors made otherwise
ineffective stimuli (LFS without postsynaptic depolarization) effective
for LTD induction, suggesting that endogenous BDNF may prevent
low-frequency inputs from inducing LTD in the developing visual cortex.
Key words:
long-term depression; brain-derived neurotrophic factor; long-term potentiation; synaptic plasticity; visual cortex; development
Copyright © 1999 Society for Neuroscience 0270-6474/99/1962122-09$05.00/0
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