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The Journal of Neuroscience, March 15, 1999, 19(6):2187-2194

Intrapreoptic Microinjection of GHRH or Its Antagonist Alters Sleep in Rats

Jianyi Zhang1, Ferenc Obál Jr4, Tong Zheng2, Jidong Fang3, Ping Taishi3, and James M. Krueger3

Departments of 1 Physiology and Biophysics and2 Anatomy and Neurobiology, University of Tennessee, Memphis, Tennessee 38163, 3 Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, Pullman, Washington 99164-6520, and 4 Department of Physiology, A. Szent-Györgyi Medical University, Szeged, Hungary

Previous reports indicate that growth hormone-releasing hormone (GHRH) is involved in sleep regulation. The site of action mediating the nonrapid eye movement sleep (NREMS)-promoting effects of GHRH is not known, but it is independent from the pituitary. GHRH (0.001, 0.01, and 0.1 nmol/kg) or a competitive antagonist of GHRH (0.003, 0.3, and 14 nmol/kg) was microinjected into the preoptic area, and the sleep-wake activity was recorded for 23 hr after injection in rats. GHRH elicited dose-dependent increases in the duration and in the intensity of NREMS compared with that in control records after intrapreoptic injection of physiological saline. The antagonist decreased the duration and intensity of NREMS and prolonged sleep latency. Consistent alterations in rapid eye movement sleep (REMS) and in brain temperature were not found. The GHRH antagonist also attenuated the enhancements in NREMS elicited by 3 hr of sleep deprivation. Histological verification of the injection sites showed that the majority of the effective injections were in the preoptic area and the diagonal band of Broca. The results indicate that the preoptic area mediates the sleep-promoting activity of GHRH.

Key words: GHRH; antagonist; intrapreoptic microinjection; non-REM sleep; EEG slow-wave activity; hypothalamus

Copyright © 1999 Society for Neuroscience  0270-6474/99/1962187-08$05.00/0


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