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Previous Article | Next Article
The Journal of Neuroscience, March 15, 1999, 19(6):2247-2260
In Vitro Analog of Operant Conditioning in Aplysia. I. Contingent Reinforcement Modifies the Functional Dynamics of an Identified Neuron
Romuald Nargeot, Douglas A. Baxter, and John H. Byrne Department of Neurobiology and Anatomy and W. M. Keck Center for the Neurobiology of Learning and Memory, The University of Texas-Houston Medical School, Houston, Texas 77030
Previously, an analog of operant conditioning in Aplysia was developed using the rhythmic motor activity in the isolated buccal ganglia. This analog expressed a key feature of operant conditioning, namely a selective enhancement in the occurrence of a designated motor pattern by contingent reinforcement. Different motor patterns generated by the buccal central pattern generator were induced by monotonic stimulation of a peripheral nerve (i.e., n.2,3). Phasic stimulation of the esophageal nerve (E n.) was used as an analog of reinforcement. The present study investigated the neuronal mechanisms associated with the genesis of different motor patterns and their modifications by contingent reinforcement. The genesis of different motor patterns was related to changes in the functional states of the pre-motor neuron B51. During rhythmic activity, B51 dynamically switched between inactive and active states. Bursting activity in B51 was associated with, and predicted, characteristic features of a specific motor pattern (i.e., pattern I). Contingent reinforcement of pattern I modified the dynamical properties of B51 by decreasing its resting conductance and threshold for eliciting plateau potentials and thus increased the occurrences of pattern I-related activity in B51. These modifications were not observed in preparations that received either noncontingent reinforcement (i.e., yoke control) or no reinforcement (i.e., control). These results suggest that a contingent reinforcement paradigm can regulate the dynamics of neuronal activity that is centrally programmed by the intrinsic cellular properties of neurons.
Key words: learning and memory; operant conditioning; contingent reinforcement; regenerative properties; neuronal dynamics; central pattern generator; buccal ganglia; Aplysia californica; B51
Copyright © 1999 Society for Neuroscience 0270-6474/99/1962247-14$05.00/0
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