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The Journal of Neuroscience, April 15, 1999, 19(8):2887-2896
Nicotinic Receptor Activation Excites Distinct Subtypes of
Interneurons in the Rat Hippocampus
A. Rory
McQuiston and
Daniel V.
Madison
Department of Molecular and Cellular Physiology, Stanford
University School of Medicine, Stanford, California 94305
We examined the function of nicotinic acetylcholine receptors
(nAChRs) in interneurons of area CA1 of the rat hippocampus. CA1
interneurons could be classified into three categories based on
nicotinic responses. The first class was depolarized by  7 nAChRs,
found in all layers of CA1 and as a group, had axonal projections to
all neuropil layers of CA1. The second class had both fast 7 and
slow non-7 nAChR depolarizing responses, was localized primarily to
the stratum oriens, and had axonal projections to the stratum
lacunosum-moleculare. The third group had no nicotinic response. This
group was found in or near the stratum pyramidale and had axonal
projections almost exclusively within and around this layer. Low
concentrations (500 nM) of nicotine desensitized fast and
slow nAChR responses. These findings demonstrate that there are
distinct subsets of interneurons with regard to nicotinic receptor
expression and with predictable morphological properties that suggest
potential cellular actions for nicotinic receptor activation in normal
CNS function and during nicotine abuse.
Key words:
hippocampus; CA1; interneuron; subtypes; nicotinic
receptor; 7; non-7; nicotine
Copyright © 1999 Society for Neuroscience 0270-6474/99/1982887-10$05.00/0
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