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The Journal of Neuroscience, April 15, 1999, 19(8):3146-3161
Axons from Anteroventral Cochlear Nucleus that Terminate in
Medial Superior Olive of Cat: Observations Related to Delay Lines
Gretchen E.
Beckius,
Ranjan
Batra, and
Douglas L.
Oliver
Department of Anatomy, University of Connecticut Health Center,
Farmington, Connecticut 06030-3405
The differences in path length of axons from the anteroventral
cochlear nuclei (AVCN) to the medial superior olive (MSO) are thought
to provide the anatomical substrate for the computation of interaural
time differences (ITD). We made small injections of biotinylated
dextran into the AVCN that produced intracellular-like filling of
axons. This permitted three-dimensional reconstructions of individual
axons and measurements of axonal length to individual terminals in MSO.
Some axons that innervated the contralateral MSO had collaterals with
lengths that were graded in the rostrocaudal direction with shorter
collaterals innervating more rostral parts of MSO and longer
collaterals innervating more caudal parts of MSO. These could innervate
all or part of the length of the MSO. Other axons had restricted
terminal fields comparable to the size of a single dendritic tree in
the MSO. In the ipsilateral MSO, some axons had a reverse, but less
steep, gradient in axonal length with greater axonal length associated
with more rostral locations; others had restricted terminal fields.
Thus, the computation of ITDs is based on gradients of axonal length in
both the contralateral and ipsilateral MSO, and these gradients may
account for a large part of the range of ITDs encoded by the MSO. Other
factors may be involved in the computation of ITDs to compensate for
differences between axons.
Key words:
auditory pathways; interaural timing differences; binaural hearing; cat; conduction velocity; superior olivary
complex
Copyright © 1999 Society for Neuroscience 0270-6474/99/1983146-16$05.00/0
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