WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (39)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gu, G.
Right arrow Articles by Simerly, R. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gu, G.
Right arrow Articles by Simerly, R. B.

 Previous Article  |  Next Article 

The Journal of Neuroscience, April 15, 1999, 19(8):3213-3222

Hormonal Regulation of Glutamate Receptor Gene Expression in the Anteroventral Periventricular Nucleus of the Hypothalamus

Guibao Gu1, Frederique Varoqueaux1, and Richard B. Simerly1, 2

1 Division of Neuroscience, Oregon Regional Primate Research Center, Beaverton, Oregon 97006, and 2 Program in Neuroscience, Oregon Health Sciences University, Portland, Oregon 97201

Glutamate plays an important role in mediating the positive feedback effects of ovarian steroids on gonadotropin secretion, and the preoptic region of the hypothalamus is a likely site of action of glutamate. The anteroventral periventricular nucleus (AVPV) of the preoptic region is an essential part of neural pathways mediating hormonal feedback on gonadotropin secretion, and it appears to provide direct inputs to gonadotropin releasing hormone (GnRH)-containing neurons. Immunohistochemistry and in situ hybridization were used in this study to define the distribution and hormonal regulation of glutamate receptor subtypes in the AVPV of juvenile female rats. Neurons that express the NMDAR1 receptor subtype are abundant in the AVPV, as are cells that express AMPA receptor subtypes (GluR1, GluR2, and GluR3 but not GluR4), and the AVPV appears to contain a dense plexus of NMDAR1-immunoreactive presynaptic terminals. However, AVPV neurons do not seem to express detectable levels of kainate receptor (GluR5, GluR6, and GluR7) or metabotropic receptor (mGluR1-6) subtypes. Treatment of ovariectomized juvenile rats with estradiol induced expression of GluR1 mRNA but did not alter levels of GluR2 or GluR3 mRNA. Treatment of estrogen-primed ovariectomized juvenile rats with progesterone caused an initial increase in GluR1 mRNA expression, followed by a small decrease 24 hr after treatment. In contrast, estrogen appears to suppress levels of NMDAR1 mRNA in the AVPV, which remained unchanged after progesterone treatment. Thus, one mechanism whereby ovarian steroids may provide positive feedback to GnRH neurons is by altering the sensitivity of AVPV neurons to glutamatergic activation.

Key words: preoptic region; gonadotropin releasing hormone; in situ hybridization; ovarian steroids; progesterone; estrogen

Copyright © 1999 Society for Neuroscience  0270-6474/99/1983213-10$05.00/0


This article has been cited by other articles:


Home page
 EndocrinologyHome page
G. Neal-Perry, D. Lebesgue, M. Lederman, J. Shu, G. D. Zeevalk, and A. M. Etgen
The Excitatory Peptide Kisspeptin Restores the Luteinizing Hormone Surge and Modulates Amino Acid Neurotransmission in the Medial Preoptic Area of Middle-Aged Rats
Endocrinology, August 1, 2009; 150(8): 3699 - 3708.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. R. Chakraborty, L. Ng, and A. C. Gore
Age-Related Changes in Estrogen Receptor {beta} in Rat Hypothalamus: A Quantitative Analysis
Endocrinology, September 1, 2003; 144(9): 4164 - 4171.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. R. Chakraborty, L. Ng, and A. C. Gore
Colocalization and Hormone Regulation of Estrogen Receptor {alpha} and N-Methyl-D-Aspartate Receptor in the Hypothalamus of Female Rats
Endocrinology, January 1, 2003; 144(1): 299 - 305.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Y. Shi and E. H. Schlenker
Neonatal sex steroids affect ventilatory responses to aspartic acid and NMDA receptor subunit 1 in rats
J Appl Physiol, June 1, 2002; 92(6): 2457 - 2466.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Orikasa, Y. Kondo, S. Hayashi, B. S. McEwen, and Y. Sakuma
Sexually dimorphic expression of estrogen receptor beta in the anteroventral periventricular nucleus of the rat preoptic area: Implication in luteinizing hormone surge
PNAS, February 14, 2002; (2002) 52707299.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. A. Richter, D. S. Spackman, J. E. Robinson, S. Dye, T. G. Harris, D. C. Skinner, and N. P. Evans
Role of Endogenous Opioid Peptides in Mediating Progesterone-Induced Disruption of the Activation and Transmission Stages of the GnRH Surge Induction Process
Endocrinology, December 1, 2001; 142(12): 5212 - 5219.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
E. Terasawa and D. L. Fernandez
Neurobiological Mechanisms of the Onset of Puberty in Primates
Endocr. Rev., February 1, 2001; 22(1): 111 - 151.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Orikasa, Y. Kondo, S. Hayashi, B. S. McEwen, and Y. Sakuma
Sexually dimorphic expression of estrogen receptor beta in the anteroventral periventricular nucleus of the rat preoptic area: Implication in luteinizing hormone surge
PNAS, March 5, 2002; 99(5): 3306 - 3311.
[Abstract] [Full Text] [PDF]


-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2010 by Society for Neuroscience ONLINE ISSN: 1529-2401
-