 |
 Previous Article | Next Article 
The Journal of Neuroscience, May 1, 1999, 19(9):3430-3439
Expression of Type 2 Iodothyronine Deiodinase in Hypothyroid Rat
Brain Indicates an Important Role of Thyroid Hormone in the Development
of Specific Primary Sensory Systems
Ana
Guadaño-Ferraz1,
Maria José
Escámez1,
Estrella
Rausell2, and
Juan
Bernal1
1 Instituto de Investigaciones Biomédicas
"Alberto Sols," Consejo Superior de Investigaciones
Cientificas-Universidad Autónoma, and 2 Departamento
de Morfología, Universidad Autónoma de Madrid, Madrid,
Spain
Thyroid hormone is an important epigenetic factor in brain
development, acting by modulating rates of gene expression. The active
form of thyroid hormone, 3,5,3'-triiodothyronine (T3) is produced in
part by the thyroid gland but also after 5'-deiodination of thyroxine
(T4) in target tissues. In brain, ~80% of T3 is formed locally from
T4 through the activity of the 5'-deiodinase type 2 (D2), an enzyme
that is expressed mostly by glial cells, tanycytes in the third
ventricle, and astrocytes throughout the brain. D2 activity is an
important point of control of thyroid hormone action because it
increases in situations of low T4, thus preserving brain T3
concentrations. In this work, we have studied the expression of D2 by
quantitative in situ hybridization in hypothyroid
animals during postnatal development. Our hypothesis was that those
regions that are most dependent on thyroid hormone should
present selective increases of D2 as a protection against
hypothyroidism. D2 mRNA concentration was increased severalfold over
normal levels in relay nuclei and cortical targets of the primary
somatosensory and auditory pathways. The results suggest that these
pathways are specifically protected against thyroid failure and that T3 has a role in the development of these structures. At the cellular level, expression was observed mainly in glial cells, although some
interneurons of the cerebral cortex were also labeled. Therefore, the
T3 target cells, mostly neurons, are dependent on local astrocytes for
T3 supply.
Key words:
thyroid hormones; deiodinases; astrocytes; barrel field; somatosensory system; auditory system; thalamus
Copyright © 1999 Society for Neuroscience 0270-6474/99/1993430-10$05.00/0
This article has been cited by other articles:
|
|
|
|
 
E. Sanchez, P. S. Singru, C. Fekete, and R. M. Lechan
Induction of Type 2 Iodothyronine Deiodinase in the Mediobasal Hypothalamus by Bacterial Lipopolysaccharide: Role of Corticosterone
Endocrinology,
May 1, 2008;
149(5):
2484 - 2493.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. A. Galton, E. T. Wood, E. A. St. Germain, C.-A. Withrow, G. Aldrich, G. M. St. Germain, A. S. Clark, and D. L. St. Germain
Thyroid Hormone Homeostasis and Action in the Type 2 Deiodinase-Deficient Rodent Brain during Development
Endocrinology,
July 1, 2007;
148(7):
3080 - 3088.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Dumitrescu, X.-H. Liao, R. E. Weiss, K. Millen, and S. Refetoff
Tissue-Specific Thyroid Hormone Deprivation and Excess in Monocarboxylate Transporter (Mct) 8-Deficient Mice
Endocrinology,
September 1, 2006;
147(9):
4036 - 4043.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. G. Trentin
Thyroid hormone and astrocyte morphogenesis.
J. Endocrinol.,
May 1, 2006;
189(2):
189 - 197.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. del Barco Barrantes, A. Montero-Pedrazuela, A. Guadano-Ferraz, M.-J. Obregon, R. Martinez de Mena, V. Gailus-Durner, H. Fuchs, T. J. Franz, S. Kalaydjiev, M. Klempt, et al.
Generation and Characterization of dickkopf3 Mutant Mice.
Mol. Cell. Biol.,
March 1, 2006;
26(6):
2317 - 2326.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Schomburg, C. Riese, M. Michaelis, E. Griebert, M. O. Klein, R. Sapin, U. Schweizer, and J. Kohrle
Synthesis and Metabolism of Thyroid Hormones Is Preferentially Maintained in Selenium-Deficient Transgenic Mice
Endocrinology,
March 1, 2006;
147(3):
1306 - 1313.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Kohrle, F. Jakob, B. Contempre, and J. E. Dumont
Selenium, the Thyroid, and the Endocrine System
Endocr. Rev.,
December 1, 2005;
26(7):
944 - 984.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Y Chan, M. H Andrews, R. Lingas, C. J McCabe, J. A Franklyn, M. D Kilby, and S. G Matthews
Maternal nutrient deprivation induces sex-specific changes in thyroid hormone receptor and deiodinase expression in the fetal guinea pig brain
J. Physiol.,
July 15, 2005;
566(2):
467 - 480.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Heuer, M. K. Maier, S. Iden, J. Mittag, E. C. H. Friesema, T. J. Visser, and K. Bauer
The Monocarboxylate Transporter 8 Linked to Human Psychomotor Retardation Is Highly Expressed in Thyroid Hormone-Sensitive Neuron Populations
Endocrinology,
April 1, 2005;
146(4):
1701 - 1706.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Simpson, F. L. R. Williams, C. Delahunty, H. van Toor, S.-Y. Wu, S. A. Ogston, T. J. Visser, R. Hume, and with collaboration from the Scottish Preterm Thyro
Serum Thyroid Hormones in Preterm Infants and Relationships to Indices of Severity of Intercurrent Illness
J. Clin. Endocrinol. Metab.,
March 1, 2005;
90(3):
1271 - 1279.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L Quignodon, C Legrand, N Allioli, A Guadano-Ferraz, J Bernal, J Samarut, and F Flamant
Thyroid hormone signaling is highly heterogeneous during pre- and postnatal brain development
J. Mol. Endocrinol.,
October 1, 2004;
33(2):
467 - 476.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C H J Verhoelst, V M Darras, S A Roelens, G M Artykbaeva, and S Van der Geyten
Type II iodothyronine deiodinase protein in chicken choroid plexus: additional perspectives on T3 supply in the avian brain
J. Endocrinol.,
October 1, 2004;
183(1):
235 - 241.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Forrest
The Developing Brain and Maternal Thyroid Hormone: Finding the Links
Endocrinology,
September 1, 2004;
145(9):
4034 - 4036.
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Gereben, J. Pachucki, A. Kollar, Z. Liposits, and C. Fekete
Ontogenic Redistribution of Type 2 Deiodinase Messenger Ribonucleic Acid in the Brain of Chicken
Endocrinology,
August 1, 2004;
145(8):
3619 - 3625.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Gurok, C. Steinhoff, B. Lipkowitz, H.-H. Ropers, C. Scharff, and U. A. Nuber
Gene Expression Changes in the Course of Neural Progenitor Cell Differentiation
J. Neurosci.,
June 30, 2004;
24(26):
5982 - 6002.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Ng, R. J. Goodyear, C. A. Woods, M. J. Schneider, E. Diamond, G. P. Richardson, M. W. Kelley, D. L. St. Germain, V. A. Galton, and D. Forrest
Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase
PNAS,
March 9, 2004;
101(10):
3474 - 3479.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Montero-Pedrazuela, J. Bernal, and A. Guadano-Ferraz
Divergent Expression of Type 2 Deiodinase and the Putative Thyroxine-Binding Protein p29, in Rat Brain, Suggests that They Are Functionally Unrelated Proteins
Endocrinology,
March 1, 2003;
144(3):
1045 - 1052.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. B. Potter, J. M. Zarach, J. M. Sisk, and C. C. Thompson
The Thyroid Hormone-Regulated Corepressor Hairless Associates with Histone Deacetylases in Neonatal Rat Brain
Mol. Endocrinol.,
November 1, 2002;
16(11):
2547 - 2560.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Forrest
Editorial: Twists in the Tail--Change-of-Function Mutations in Thyroid Hormone Receptors
Endocrinology,
July 1, 2002;
143(7):
2466 - 2468.
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Cuadrado, C. Navarro-Yubero, H. Furneaux, J. Kinter, P. Sonderegger, and A. Munoz
HuD binds to three AU-rich sequences in the 3'-UTR of neuroserpin mRNA and promotes the accumulation of neuroserpin mRNA and protein
Nucleic Acids Res.,
May 15, 2002;
30(10):
2202 - 2211.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. C. Bianco, D. Salvatore, B. Gereben, M. J. Berry, and P. R. Larsen
Biochemistry, Cellular and Molecular Biology, and Physiological Roles of the Iodothyronine Selenodeiodinases
Endocr. Rev.,
February 1, 2002;
23(1):
38 - 89.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Flamant, A.-L. Poguet, M. Plateroti, O. Chassande, K. Gauthier, N. Streichenberger, A. Mansouri, and J. Samarut
Congenital Hypothyroid Pax8-/- Mutant Mice Can Be Rescued by Inactivating the TR{alpha} Gene
Mol. Endocrinol.,
January 1, 2002;
16(1):
24 - 32.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Rusch, L. Ng, R. Goodyear, D. Oliver, I. Lisoukov, B. Vennstrom, G. Richardson, M. W. Kelley, and D. Forrest
Retardation of Cochlear Maturation and Impaired Hair Cell Function Caused by Deletion of All Known Thyroid Hormone Receptors
J. Neurosci.,
December 15, 2001;
21(24):
9792 - 9800.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Peeters, C. Fekete, C. Goncalves, G. Legradi, H. M. Tu, J. W. Harney, A. C. Bianco, R. M. Lechan, and P. R. Larsen
Regional physiological adaptation of the central nervous system deiodinases to iodine deficiency
Am J Physiol Endocrinol Metab,
July 1, 2001;
281(1):
E54 - E61.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Morreale de Escobar, M. Jesús Obregón, and F. Escobar del Rey
Is Neuropsychological Development Related to Maternal Hypothyroidism or to Maternal Hypothyroxinemia?
J. Clin. Endocrinol. Metab.,
November 1, 2000;
85(11):
3975 - 3987.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A. Campos-Barros, L. L. Amma, J. S. Faris, R. Shailam, M. W. Kelley, and D. Forrest
Type 2 iodothyronine deiodinase expression in the cochlea before the onset of hearing
PNAS,
February 1, 2000;
97(3):
1287 - 1292.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. M. Leonard, S. J. Stachelek, M. Safran, A. P. Farwell, T. F. Kowalik, and J. L. Leonard
Cloning, Expression, and Functional Characterization of the Substrate Binding Subunit of Rat Type II Iodothyronine 5'-Deiodinase
J. Biol. Chem.,
August 11, 2000;
275(33):
25194 - 25201.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
.gif?ad=17923&adview=true)
