QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (10) Citing Articles via Google Scholar Google Scholar Articles by Doughty, M. L. Articles by Mariani, J. Search for Related Content PubMed PubMed Citation Articles by Doughty, M. L. Articles by Mariani, J.

 Previous Article  |  Next Article 

The Journal of Neuroscience, May 1, 1999, 19(9):3448-3456

Afferent-Target Cell Interactions in the Cerebellum: Negative Effect of Granule Cells on Purkinje Cell Development in Lurcher Mice

Martin L. Doughty¹, Ann Lohof^{1, 2}, Fekrije Selimi¹, Nicole Delhaye-Bouchaud¹, and Jean Mariani¹

¹ Laboratoire de Neurobiologie du Développement, Institut des Neurosciences (Unite Mixte de Recherche 7624), Université Pierre et Marie Curie, 75005 Paris, France, and ² Laboratoire de Neurobiologie, Ecole Normale Supérieure, 75005 Paris, France

Lurcher (Lc) is a gain-of-function mutation in the 2 glutamate receptor gene that results in a large, constitutive inward current in the cerebellar Purkinje cells of +/Lc mice. +/Lc Purkinje cells fail to differentiate fully and die during postnatal development. In normal mice, interactions with granule cells promote Purkinje cell dendritic differentiation. Partial destruction of the granule cell population in young +/Lc mice by x irradiation resulted in a significant increase in Purkinje cell dendritic growth and improved cytoplasmic structure but did not prevent Purkinje cell death. These results indicate two components to Purkinje cell abnormalities in +/Lc mice: a retardation/blockade of dendritic development that is mediated by interactions with granule cells and the death of the cell. Thus, the normal trophic effects of granule cell interaction on Purkinje cell development are absent in the +/Lc cerebellum, suggesting that granule cells are powerful regulators of Purkinje cell differentiation.

Key words: Lurcher; Purkinje cell; dendrites; granule cell; parallel fiber; synapse; delta 2 glutamate receptor

---

Copyright © 1999 Society for Neuroscience  0270-6474/99/1993448-09$05.00/0

This article has been cited by other articles:

				H. Hirai and T. Launey The Regulatory Connection between the Activity of Granule Cell NMDA Receptors and Dendritic Differentiation of Cerebellar Purkinje Cells J. Neurosci., July 15, 2000; 20(14): 5217 - 5224. [Abstract] [Full Text] [PDF]

				F. Selimi, M. W. Vogel, and J. Mariani Bax Inactivation in Lurcher Mutants Rescues Cerebellar Granule Cells But Not Purkinje Cells or Inferior Olivary Neurons J. Neurosci., July 15, 2000; 20(14): 5339 - 5345. [Abstract] [Full Text] [PDF]

				M. L. Doughty, P. L. De Jager, S. J. Korsmeyer, and N. Heintz Neurodegeneration in Lurcher Mice Occurs via Multiple Cell Death Pathways J. Neurosci., May 15, 2000; 20(10): 3687 - 3694. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help