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The Journal of Neuroscience, May 1, 1999, 19(9):3545-3555

NK-1 Receptor Immunoreactivity in Distinct Morphological Types of Lamina I Neurons of the Primate Spinal Cord

X. H. Yu¹, E.-T. Zhang³, A. D. Craig³, R. Shigemoto⁴, A. Ribeiro-da-Silva^{1, 2}, and Y. De Koninck¹

¹ Department of Pharmacology and Therapeutics, and ² Anatomy and Cell Biology, McGill University, Montréal, Quebec, H3G 1Y6 Canada, ³ Division of Neurobiology, Barrow Neurological Institute, Phoenix, Arizona 85013, and ⁴ National Institute for Physiological Sciences, Okazaki 444-8585, Japan

In cat and monkey, lamina I cells can be classified into three basic morphological types (fusiform, pyramidal, and multipolar), and recent intracellular labeling evidence in the cat indicates that fusiform and multipolar lamina I cells are two different types of nociceptive cells, whereas pyramidal cells are innocuous thermoreceptive-specific. Because earlier observations indicated that only nociceptive dorsal horn neurons respond to substance P (SP), we examined which morphological types of lamina I neurons express receptors for SP (NK-1r).

We categorized NK-1r-immunoreactive (IR) lamina I neurons in serial horizontal sections from the cervical and lumbar enlargements of four monkeys. Consistent results were obtained by two independent teams of observers. Nearly all NK-1r-IR cells were fusiform (42%) or multipolar (43%), but only 6% were pyramidal (with 9% unclassified). We obtained similar findings in three monkeys in which we used double-labeling immunocytochemistry to identify NK-1r-IR and spinothalamic lamina I neurons retrogradely labeled with cholera toxin subunit b from the thalamus; most NK-1r-IR lamina I spinothalamic neurons were fusiform (48%) or multipolar (33%), and only 10% were pyramidal. In contrast, most (~75%) pyramidal and some (~25%) fusiform and multipolar lamina I spinothalamic neurons did not display NK-1r immunoreactivity.

These data indicate that most fusiform and multipolar lamina I neurons in the monkey can express NK-1r, consistent with the idea that both types are nociceptive, whereas only a small proportion of lamina I pyramidal cells express this receptor, consistent with the previous finding that they are non-nociceptive. However, these findings also indicate that not all nociceptive lamina I neurons express receptors for SP.

Key words: dorsal horn; spinothalamic; nociception; substance P; monkey; functional specialization

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Copyright © 1999 Society for Neuroscience  0270-6474/99/1993545-11$05.00/0

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