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Journal of Neuroscience, Vol 2, 1-10, Copyright © 1982 by Society for Neuroscience
Extracellular current flow and the site of transduction by vertebrate hair cells
AJ Hudspeth
The transduction process of a vertebrate hair cell commences with the
application of mechanical stimuli to the hair bundle, a cluster
microvillous stereocilia and single axonemal kinocilium. In an effort to
determine where within the hair bundle transduction occurs, I have measured
extracellular potentials around the hair bundles of mechanically stimulated
hair cells from the bullfrog's sacculus. Stimulus-dependent signals up to
17 microV in peak-to-peak amplitude have been found. These appear to be due
to the flow of transduction current on the basis of their amplitude, phase,
dependence on stimulus size and orientation, proportionality to membrane
potential, and sensitivity to an ototoxic antibiotic. The responses are
consistently larger near the top of the hair bundle than at its base,
suggesting that the transduction apparatus lies at or near the distal ends
of the stereocilia.
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