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 Previous Article

Journal of Neuroscience, Vol 2, 1660-1671, Copyright © 1982 by Society for Neuroscience

ARTICLE

Immunocytochemical analysis of serotonergic axons in laminae I and II of the lumbar spinal cord of the cat

MA Ruda, J Coffield and HW Steinbusch

Serotonergic axons in the superficial dorsal horn were examined at the light and electron microscopic levels using an antibody specific for serotonin (5-HT). Immunoreactive 5-HT axons were most numerous in lamina I and fewest in lamina IIb. The 5-HT axons tended to orient rostrocaudally as they traveled long distances in the gray matter. Based on the size of the 5-HT varicosities along a strand of axon, at least three different types of 5-HT axons were observed at the light microscopic level. Ultrastructurally, 5-HT immunoreactive axonal endings contained either a mixture of flattened and small oval agranular vesicles or a relatively homogeneous population of oval vesicles. 5-HT endings synapsed primarily on small caliber dendritic shafts. They also were found synapsing on large caliber dendritic shafts, dendritic spines, and neuronal cell bodies. Based on the laminar location of 5-HT axosomatic synapses and the presence of 5-HT synapses on different morphological types of dendrites, we propose that 5-HT modulates the response properties of at least three different types of neurons in the superficial dorsal horn.




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Copyright 2008 by Society for Neuroscience ONLINE ISSN: 1529-2401
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