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Journal of Neuroscience, Vol 2, 1786-1792, Copyright © 1982 by Society for Neuroscience

ARTICLE

Intracellular identification of central noradrenergic and serotonergic neurons by a new double labeling procedure

GK Aghajanian and CP Vandermaelen

The purpose of this study was to ascertain the identity of presumed noradrenergic or serotonergic neurons recorded by single cell techniques in the mammalian brain. A double labeling method was developed in which intracellular injections of a red fluorescing dye (ethidium bromide) could be co-localized with the formaldehyde-induced green fluorescence of norepinephrine or yellow fluorescence of serotonin. By this method, neurons of the rat locus coeruleus that display a characteristic activation-inhibition response to noxious stimuli were confirmed to be noradrenergic; the slow, rhythmically firing neurons of the dorsal raphe nucleus were confirmed to be serotonergic.

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