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Journal of Neuroscience, Vol 2, 199-205, Copyright © 1982 by Society for Neuroscience
Modulation by estradiol of serotonin receptors in brain
A Biegon and BS McEwen
Estrogens were found to exert a biphasic effect on the density of serotonin
receptors in the female rat brain: an acute reduction in serotonin receptor
density throughout the brain is followed 48 to 72 hr later by a selective
increase in those brain regions known to contain estrogen
receptors--hypothalamus, preoptic area, and amygdala. The acute reduction
in serotonin receptor density can be mimicked by estradiol in vitro. We
conclude that estradiol may have a fast, direct effect on brain membranes
to modify serotonin receptor availability, while exerting a slow effect on
the same receptors through an interaction with intracellular estrogen
receptors in those brain regions that contain them. The observation that
female sex hormones are involved in the regulation of serotonin receptors
may have important implications in the understanding of female sexual
behavior in the female rat and in the understanding of hormone-linked
emotional disturbances in women.
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