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Journal of Neuroscience, Vol 2, 292-302, Copyright © 1982 by Society for Neuroscience
Medial septal area lesions disrupt theta rhythm and cholinergic staining in medial entorhinal cortex and produce impaired radial arm maze behavior in rats
SJ Mitchell, JN Rawlins, O Steward and DS Olton
This study was designed to determine (1) which brain area paces the theta
rhythm in the medial entorhinal cortex (MEC) of rats and (2) the extent to
which the behavioral effects of lesions in the medial septal area (MSA),
which disrupt the cholinesterase-related pathway to the hippocampal
formation, resemble the effects previously reported to result from
fimbria-fornix lesions. MSA lesions abolished or decreased theta rhythm in
dorsal hippocampus (DHPC) and MEC; acetylcholinesterase (AChE) staining was
depleted or diminished in all of the hippocampus and entorhinal cortex.
Rats with MSA lesions were impaired on acquisition of a radial arm maze
task. Unilateral fimbria lesions left theta rhythm and AChE staining
essentially unaltered in ipsilateral DHPC and MEC but depleted AChE in
ipsilateral ventral hippocampus (VHPC) and ventral lateral entorhinal
cortex (LEC). A lesion of the dorsal fornix at the level of the hippocampal
flexure left ipsilateral DHPC theta rhythm and AChE stain unaltered while
causing a substantial reduction in theta rhythm and depletion of AChE in
ipsilateral MEC. AChE staining was complete in VHPC and LEC. These results
suggest tha MSA paces MEC theta rhythm and that the presumed cholinergic
projection which mediates this function travels in the dorsal fornix. The
fimbria carries a presumed cholinergic projection to ventral LEC. Rats with
MSA lesions can learn a radial arm maze task, unlike rats with fimbria-
fornix lesions, but they learn significantly slower than normal rats.
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