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Journal of Neuroscience, Vol 2, 354-360, Copyright © 1982 by Society for Neuroscience
The influence of sex hormones on antidepressant-induced alterations in neurotransmitter receptor binding
DA Kendall, GM Stancel and SJ Enna
Long term (21-day) treatment with antidepressants induces a decrease in
beta-adrenergic and serotonin 2 (5-HT2) receptor binding in rat brain
frontal cortex. Since hormone imbalances are known to be associated with
affective illness, the present study was undertaken to determine whether
sex hormones influence these alterations in neurotransmitter receptor
binding. Using receptor binding assays, we found that castration abolishes
the decline in the concentration of 5-HT2, but not beta-adrenergic,
receptors brought on by chronic imipramine or iprindole treatment in both
male and female rats. In contrast, the receptor responses to trazodone,
mianserin, and pargyline were not influenced by surgery. Furthermore,
mianserin was found to reduce beta- adrenergic binding in intact females,
but not males, suggesting a sex- related specificity with regard to the
response to this agent. Testosterone and estrogen, but not
dihydrotestosterone, reversed the effects of castration in males,
suggesting that the interaction between the steroids and antidepressants is
mediated through estrogenic, rather than androgenic, receptors. The results
indicate that the receptor responses to some antidepressant drugs is
dependent, at least in part, on the hormonal state of the animals.
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