 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 2, 942-957, Copyright © 1982 by Society for Neuroscience
Ribbon synapses in the developing intact and cultured organ of Corti in the mouse
HM Sobkowicz, JE Rose, GE Scott and SM Slapnick
Over 100 synaptic ribbons were studied in the intact animal from birth to
the 23rd day and over 500 were studied in the isolated organ up to 24 days
in culture. Our findings suggest that synaptogenesis in the cochlea of the
mouse occurs mainly postnatally and lasts at least 14 days. Afferent
synapses of young cochleas are characterized by round ribbons which are
attached to the presynaptic membrane by two rodlets, each surrounded by a
discrete triangular density. The postsynaptic density is continuous and
coextends with the presynaptic complex. The single layer of vesicles
surrounding the dense body of the ribbon is disrupted by the presynaptic
densities. In an afferent synapse of the adolescent animal, the predominant
organelle is a plate ribbon--often laminated--which measures on the average
approximately 1000 A wide, 2000 A tall, and 1500 A long (one section = 700
A). The ribbon is attached to a presynaptic density, arcuate in form; a row
of synaptic vesicles is aligned along each side of the arcuate density. The
presynaptic membrane forms a trough accommodating the ribbon. The
postsynaptic density exceeds the territory of the ribbon. Similar
development of the synapse also may be observed in culture. Structural
variability of ribbons (seen especially in culture), clustering of ribbons,
multiribbon synapses, and ribbon families seem to be characteristic of
early development. The occurrence of ring-like or fenestrated ribbons in
the intact adolescent animal suggests a limited life span of the organelle.
A decrease in the ribbon population of the outer hair cells, to about 20%
of the total number, occurs postnatally in the intact animal. A similar
decrease occurs also in culture. This implies that the ribbon population is
not affected by the efferent influx. The mature cochlear ribbon appears
comparable to those of the retina and some ampullary organs of electric
fishes.
This article has been cited by other articles:
|
|
|
|
 
S. L. Johnson, A. Forge, M. Knipper, S. Munkner, and W. Marcotti
Tonotopic Variation in the Calcium Dependence of Neurotransmitter Release and Vesicle Pool Replenishment at Mammalian Auditory Ribbon Synapses
J. Neurosci.,
July 23, 2008;
28(30):
7670 - 7678.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Beurg, S. Safieddine, I. Roux, Y. Bouleau, C. Petit, and D. Dulon
Calcium- and Otoferlin-Dependent Exocytosis by Immature Outer Hair Cells
J. Neurosci.,
February 20, 2008;
28(8):
1798 - 1803.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Neef, D. Khimich, P. Pirih, D. Riedel, F. Wolf, and T. Moser
Probing the Mechanism of Exocytosis at the Hair Cell Ribbon Synapse
J. Neurosci.,
November 21, 2007;
27(47):
12933 - 12944.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. A. Jones, P. A. Leake, R. L. Snyder, O. Stakhovskaya, and B. Bonham
Spontaneous Discharge Patterns in Cochlear Spiral Ganglion Cells Before the Onset of Hearing in Cats
J Neurophysiol,
October 1, 2007;
98(4):
1898 - 1908.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L.-C. Huang, P. R. Thorne, G. D. Housley, and J. M. Montgomery
Spatiotemporal definition of neurite outgrowth, refinement and retraction in the developing mouse cochlea
Development,
August 15, 2007;
134(16):
2925 - 2933.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Sendin, A. V. Bulankina, D. Riedel, and T. Moser
Maturation of Ribbon Synapses in Hair Cells Is Driven by Thyroid Hormone
J. Neurosci.,
March 21, 2007;
27(12):
3163 - 3173.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. L Johnson, W. Marcotti, and C. J Kros
Increase in efficiency and reduction in Ca2+ dependence of exocytosis during development of mouse inner hair cells
J. Physiol.,
February 15, 2005;
563(1):
177 - 191.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. W Edmonds, F. D Gregory, and F. E Schweizer
Evidence that fast exocytosis can be predominantly mediated by vesicles not docked at active zones in frog saccular hair cells
J. Physiol.,
October 15, 2004;
560(2):
439 - 450.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Beutner and T. Moser
The Presynaptic Function of Mouse Cochlear Inner Hair Cells during Development of Hearing
J. Neurosci.,
July 1, 2001;
21(13):
4593 - 4599.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Moser and D. Beutner
Kinetics of exocytosis and endocytosis at the cochlear inner hair cell afferent synapse of the mouse
PNAS,
January 18, 2000;
97(2):
883 - 888.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
