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The Journal of Neuroscience, January 1, 2000, 20(1):451-463

Impaired Recognition Memory in Monkeys after Damage Limited to the Hippocampal Region

Stuart M. Zola^{1, 2, 3}, Larry R. Squire^{1, 2, 3, 4}, Edmond Teng³, Lisa Stefanacci², Elizabeth A. Buffalo³, and Robert E. Clark²

¹ Veterans Affairs Medical Center, San Diego, California 92126, and ² Departments of Psychiatry, ³ Neurosciences, and ⁴ Psychology, University of California, La Jolla, California 92093

Monkeys with lesions limited to the hippocampal region (the hippocampus proper, the dentate gyrus, and the subiculum) were impaired on two tasks of recognition memory: delayed nonmatching to sample and the visual paired-comparison task. Recognition memory was impaired in five different groups of monkeys, whether the lesions were made by an ischemic procedure, by radio frequency, or by ibotenic acid. The finding that the hippocampal region is essential for normal recognition memory performance is considered in the context of current ideas about the role of the hippocampus in declarative memory.

Key words: hippocampus; recognition memory; monkeys; radio-frequency lesions; ischemic lesions; ibotenic acid lesions; delayed nonmatching to sample; visual paired comparison

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Copyright © 2000 Society for Neuroscience  0270-6474/0/201451-13$05.00/0

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