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The Journal of Neuroscience, 2000, 20:RC53:1-5

RAPID COMMUNICATION
NADPH Oxidase Contributes Directly to Oxidative Stress and Apoptosis in Nerve Growth Factor-Deprived Sympathetic Neurons

Steven P. Tammariello¹, Mark T. Quinn², and Steven Estus¹

¹ Department of Physiology, Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky 40536, ² Department of Veterinary Molecular Biology, Montana State University, Bozeman, Montana 59717

Reactive oxygen species (ROS) are necessary for programmed cell death (PCD) in neurons, but the underlying ROS-producing enzymes have not been identified. NADPH oxidase produces ROS, although the expression of its five subunits are thought to be restricted largely to non-neuronal cells. Here, we show that NADPH oxidase subunits are present in neurons. Moreover, both an NADPH oxidase inhibitor, diphenyleneiodonium, and NAPDH oxidase genetic deficiency inhibit apoptosis in a classic model of PCD, i.e., NGF-deprived sympathetic neurons. Overall, these results indicate that NADPH oxidase is unexpectedly present in neurons and can contribute to neuronal apoptosis.

Key words: apoptosis; sympathetic neuron; oxidative stress; reactive oxygen species; NADPH oxidase; programmed cell death

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Copyright © 0000 Society for Neuroscience  0270-6474/0/$05.00/0

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