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The Journal of Neuroscience, May 15, 2000, 20(10):3736-3744
Synapsin III: Developmental Expression, Subcellular Localization, and Role in Axon Formation
Adriana Ferreira1, 2, Hung-Teh Kao3, 4, Jian Feng3, Mark Rapoport1, and Paul Greengard3 1 Department of Cell and Molecular Biology and 2 Institute for Neuroscience, Northwestern University, Chicago, Illinois 60611, 3 Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, and 4 Department of Psychiatry, New York University Medical Center, New York, New York 10016
We have investigated the developmental expression and subcellular localization of synapsin III, the newest member of the synapsin family, in cultured mouse hippocampal neurons. Our results indicate that synapsin III is expressed early during development, with levels peaking 7 d after plating and declining thereafter. Synapsin III is highly concentrated in growth cones. Using specific antisense oligonucleotides, we have also examined the effect of depleting synapsin III on neurite elongation and synaptogenesis. When synapsin III was suppressed immediately after plating, hippocampal neurons extended minor processes but failed to differentiate one of them as the axon. The suppression of synapsin III after axonal elongation did not affect the time course of synapse formation. The results indicate that synapsin III has a developmental time course, a subcellular localization, and a developmental function very different from those of synapsin I and synapsin II.
Key words: synapsin III; neuronal polarity; growth cones; axonal elongation; synaptogenesis; antisense oligonucleotides
Copyright © 2000 Society for Neuroscience 0270-6474/00/20103736-09$05.00/0
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