QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (72) Citing Articles via Google Scholar Google Scholar Articles by Niblock, M. M. Articles by Riddle, D. R. Search for Related Content PubMed PubMed Citation Articles by Niblock, M. M. Articles by Riddle, D. R.

 Previous Article  |  Next Article 

Insulin-Like Growth Factor I Stimulates Dendritic Growth in Primary Somatosensory Cortex

Mary M. Niblock², Judy K. Brunso-Bechtold^{1, 2}, and David R. Riddle^{1, 2}

¹ Department of Neurobiology and Anatomy and ² Program in Neuroscience, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1010

The temporal and spatial distributions of several growth factors suggest roles in the regulation of neuronal differentiation in the neocortex. Among such growth factors, the insulin-like growth factors (IGF-I and -II) are of particular interest because they are available to neurons from multiple sources under independent control. IGF-I is produced by many neurons throughout the brain and also by cells in the cerebral vasculature. IGF-II is found at high levels in the CSF, and both IGF-I and IGF-II cross the blood-brain barrier. Thus, the IGFs may act as both paracrine and endocrine regulators of neuronal development. As an initial step toward understanding the influence of IGFs in the developing cerebral cortex, the present study examined the effects of IGF-I and of the neurotrophins brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) on the dendritic complexity of layer 2 pyramidal neurons. The results demonstrate that IGF-I increased the branching and total extent of both apical and basal dendrites of pyramidal cells in organotypic slices of rat primary somatosensory cortex. BDNF and NT-3 also enhanced dendritic development, but the two neurotrophins increased the extent of only basal, not apical, dendrites and promoted greater elongation than was seen after IGF-I treatment. These results provide direct evidence that IGF-I can regulate the dendritic elaboration of cortical neurons and indicate that endogenous IGFs may influence dendritic differentiation and the formation of cortical connections. In addition, IGF-dependent regulation of dendritic structure may represent a link between age-related declines in IGFs and cognitive deficits seen in senescence.

Key words: growth factors; neurotrophins; organotypic slice; neocortex; dendrites; aging

---

Copyright © 2000 Society for Neuroscience  0270-6474/00/20114165-12$05.00/0

This article has been cited by other articles:

				W.-C. Sin, D. M. Moniz, M. A. Ozog, J. E. Tyler, M. Numata, and J. Church Regulation of Early Neurite Morphogenesis by the Na+/H+ Exchanger NHE1 J. Neurosci., July 15, 2009; 29(28): 8946 - 8959. [Abstract] [Full Text] [PDF]

				A. Joseph D'Ercole and P. Ye Expanding the Mind: Insulin-Like Growth Factor I and Brain Development Endocrinology, December 1, 2008; 149(12): 5958 - 5962. [Abstract] [Full Text] [PDF]

				X.-P. Zhou, K.-Y. Wu, B. Liang, X.-Q. Fu, and Z.-G. Luo TrkB-mediated activation of geranylgeranyltransferase I promotes dendritic morphogenesis PNAS, November 4, 2008; 105(44): 17181 - 17186. [Abstract] [Full Text] [PDF]

				S. J. Colcombe, K. I. Erickson, P. E. Scalf, J. S. Kim, R. Prakash, E. McAuley, S. Elavsky, D. X. Marquez, L. Hu, and A. F. Kramer Aerobic Exercise Training Increases Brain Volume in Aging Humans J Gerontol A Biol Sci Med Sci, November 1, 2006; 61(11): 1166 - 1170. [Abstract] [Full Text] [PDF]

				F. Rasmussen Paternal age, size at birth, and size in young adulthood - risk factors for schizophrenia Eur. J. Endocrinol., November 1, 2006; 155(suppl_1): S65 - S69. [Abstract] [Full Text] [PDF]

				I. C Maier and M. E Schwab Sprouting, regeneration and circuit formation in the injured spinal cord: factors and activity Phil Trans R Soc B, September 29, 2006; 361(1473): 1611 - 1634. [Abstract] [Full Text] [PDF]

				L. Gao, L. A. C. Blair, G. D. Salinas, L. A. Needleman, and J. Marshall Insulin-like growth factor-1 modulation of CaV1.3 calcium channels depends on Ca2+ release from IP3-sensitive stores and calcium/calmodulin kinase II phosphorylation of the alpha1 subunit EF hand. J. Neurosci., June 7, 2006; 26(23): 6259 - 6268. [Abstract] [Full Text] [PDF]

				A. B. Taylor and J. R. Fallon Dendrites Contain a Spacing Pattern J. Neurosci., January 25, 2006; 26(4): 1154 - 1163. [Abstract] [Full Text] [PDF]

				D. Gunnell, L. L. Miller, I. Rogers, J. M. P. Holly, and and the ALSPAC Study Team Association of Insulin-like Growth Factor I and Insulin-like Growth Factor-Binding Protein-3 With Intelligence Quotient Among 8- to 9-Year-Old Children in the Avon Longitudinal Study of Parents and Children Pediatrics, November 1, 2005; 116(5): e681 - e686. [Abstract] [Full Text] [PDF]

				L. Shi, M. C. Linville, E. W. Tucker, W. E. Sonntag, and J. K. Brunso-Bechtold Differential Effects of Aging and Insulin-like Growth Factor-1 on Synapses in CA1 of Rat Hippocampus Cereb Cortex, May 1, 2005; 15(5): 571 - 577. [Abstract] [Full Text] [PDF]

				D. N. Abrous, M. Koehl, and M. Le Moal Adult Neurogenesis: From Precursors to Network and Physiology Physiol Rev, April 1, 2005; 85(2): 523 - 569. [Abstract] [Full Text] [PDF]

				H. Gutierrez, V. A. Hale, X. Dolcet, and A. Davies NF-{kappa}B signalling regulates the growth of neural processes in the developing PNS and CNS Development, April 1, 2005; 132(7): 1713 - 1726. [Abstract] [Full Text] [PDF]

				H. Gutierrez, X. Dolcet, M. Tolcos, and A. Davies HGF regulates the development of cortical pyramidal dendrites Development, August 1, 2004; 131(15): 3717 - 3726. [Abstract] [Full Text] [PDF]

				M. J. Wirth, A. Brun, J. Grabert, S. Patz, and P. Wahle Accelerated dendritic development of rat cortical pyramidal cells and interneurons after biolistic transfection with BDNF and NT4/5 Development, December 1, 2003; 130(23): 5827 - 5838. [Abstract] [Full Text] [PDF]

				H. Shan, M. L. Messi, Z. Zheng, Z.-M. Wang, and O. Delbono Preservation of motor neuron Ca2+ channel sensitivity to insulin-like growth factor-1 in brain motor cortex from senescent rat J. Physiol., November 15, 2003; 553(1): 49 - 63. [Abstract] [Full Text] [PDF]

				J. A. Gorski, S. R. Zeiler, S. Tamowski, and K. R. Jones Brain-Derived Neurotrophic Factor Is Required for the Maintenance of Cortical Dendrites J. Neurosci., July 30, 2003; 23(17): 6856 - 6865. [Abstract] [Full Text] [PDF]

				X. Jin, H. Hu, P. H. Mathers, and A. Agmon Brain-Derived Neurotrophic Factor Mediates Activity-Dependent Dendritic Growth in Nonpyramidal Neocortical Interneurons in Developing Organotypic Cultures J. Neurosci., July 2, 2003; 23(13): 5662 - 5673. [Abstract] [Full Text] [PDF]

				A. Nicot, V. Lelievre, J. Tam, J. A. Waschek, and E. DiCicco-Bloom Pituitary Adenylate Cyclase-Activating Polypeptide and Sonic Hedgehog Interact to Control Cerebellar Granule Precursor Cell Proliferation J. Neurosci., November 1, 2002; 22(21): 9244 - 9254. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help