 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
Cellular Mechanisms of Long-Lasting Adaptation in Visual Cortical Neurons In Vitro
Maria V. Sanchez-Vives, Lionel G. Nowak, and David A. McCormick Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510
The cellular mechanisms of spike-frequency adaptation during prolonged discharges and of the slow afterhyperpolarization (AHP) that follows, as occur in vivo with contrast adaptation, were investigated with intracellular recordings of cortical neurons in slices of ferret primary visual cortex. Intracellular injection of 2 Hz sinusoidal or constant currents for 20 sec resulted in a slow (
= 1-10 sec) spike-frequency adaptation, the degree of which varied widely among neurons. Reducing either [Ca2+]o or [Na+]o reduced the rate of spike-frequency adaptation. After the prolonged discharge was a slow (12-75 sec) AHP that was associated with an increase in membrane conductance and a rightward shift in the discharge frequency versus injected current relationship. The reversal potential of the slow AHP was sensitive to changes in [K+]o, indicating that it was mediated by a K+ current. Blockade of transmembrane Ca2+ conductances did not reduce the slow AHP. In contrast, reductions of [Na+]o reduced the slow AHP, even in the presence of pronounced Ca2+ spikes. We suggest that the activation of Na+-activated and Ca2+-activated K+ currents plays an important role in prolonged spike-frequency adaptation and therefore may contribute to contrast adaptation and other forms of adaptation in the visual system in vivo.
Key words: plasticity; vision; K+ currents; pyramidal cell; receptive field; dynamics
Copyright © 2000 Society for Neuroscience 0270-6474/00/20114286-14$05.00/0
This article has been cited by other articles:
I. Dean, B. L. Robinson, N. S. Harper, and D. McAlpine
Rapid Neural Adaptation to Sound Level Statistics
J. Neurosci., June 18, 2008; 28(25): 6430 - 6438.
[Abstract] [Full Text] [PDF]
M. Diaz-Quesada and M. Maravall
Intrinsic Mechanisms for Adaptive Gain Rescaling in Barrel Cortex
J. Neurosci., January 16, 2008; 28(3): 696 - 710.
[Abstract] [Full Text] [PDF]
M. A. Hietanen, N. A. Crowder, N. S. C. Price, and M. R. Ibbotson
Influence of adapting speed on speed and contrast coding in the primary visual cortex of the cat
J. Physiol., October 15, 2007; 584(2): 451 - 462.
[Abstract] [Full Text] [PDF]
K. S. Gaudry and P. Reinagel
Contrast Adaptation in a Nonadapting LGN Model
J Neurophysiol, September 1, 2007; 98(3): 1287 - 1296.
[Abstract] [Full Text] [PDF]
K. S. Gaudry and P. Reinagel
Benefits of Contrast Normalization Demonstrated in Neurons and Model Cells
J. Neurosci., July 25, 2007; 27(30): 8071 - 8079.
[Abstract] [Full Text] [PDF]
D. L. Ringach and B. J. Malone
The Operating Point of the Cortex: Neurons as Large Deviation Detectors
J. Neurosci., July 18, 2007; 27(29): 7673 - 7683.
[Abstract] [Full Text] [PDF]
T. Duong and R. D. Freeman
Spatial Frequency-Specific Contrast Adaptation Originates in the Primary Visual Cortex
J Neurophysiol, July 1, 2007; 98(1): 187 - 195.
[Abstract] [Full Text] [PDF]
D. Hess, E. Nanou, and A. El Manira
Characterization of Na+-Activated K+ Currents in Larval Lamprey Spinal Cord Neurons
J Neurophysiol, May 1, 2007; 97(5): 3484 - 3493.
[Abstract] [Full Text] [PDF]
A. Kohn
Visual Adaptation: Physiology, Mechanisms, and Functional Benefits
J Neurophysiol, May 1, 2007; 97(5): 3155 - 3164.
[Abstract] [Full Text] [PDF]
Y. Katz, J. E. Heiss, and I. Lampl
Cross-Whisker Adaptation of Neurons in the Rat Barrel Cortex
J. Neurosci., December 20, 2006; 26(51): 13363 - 13372.
[Abstract] [Full Text] [PDF]
G. La Camera, A. Rauch, D. Thurbon, H.-R. Luscher, W. Senn, and S. Fusi
Multiple Time Scales of Temporal Response in Pyramidal and Fast Spiking Cortical Neurons
J Neurophysiol, December 1, 2006; 96(6): 3448 - 3464.
[Abstract] [Full Text] [PDF]
A. J. Shepherd
Local and global motion after-effects are both enhanced in migraine, and the underlying mechanisms differ across cortical areas
Brain, July 1, 2006; 129(7): 1833 - 1843.
[Abstract] [Full Text] [PDF]
J. J. Lawrence, J. M. Statland, Z. M. Grinspan, and C. J. McBain
Cell type-specific dependence of muscarinic signalling in mouse hippocampal stratum oriens interneurones
J. Physiol., February 1, 2006; 570(3): 595 - 610.
[Abstract] [Full Text] [PDF]
N. A. Crowder, N.S.C. Price, M. A. Hietanen, B. Dreher, C.W.G. Clifford, and M. R. Ibbotson
Relationship Between Contrast Adaptation and Orientation Tuning in V1 and V2 of Cat Visual Cortex
J Neurophysiol, January 1, 2006; 95(1): 271 - 283.
[Abstract] [Full Text] [PDF]
D. Z. Jin, V. Dragoi, M. Sur, and H. S. Seung
Tilt Aftereffect and Adaptation-Induced Changes in Orientation Tuning in Visual Cortex
J Neurophysiol, December 1, 2005; 94(6): 4038 - 4050.
[Abstract] [Full Text] [PDF]
K. Karmeier, H. G. Krapp, and M. Egelhaaf
Population Coding of Self-Motion: Applying Bayesian Analysis to a Population of Visual Interneurons in the Fly
J Neurophysiol, September 1, 2005; 94(3): 2182 - 2194.
[Abstract] [Full Text] [PDF]
R. Scuri, R. Mozzachiodi, and M. Brunelli
Role for Calcium Signaling and Arachidonic Acid Metabolites in the Activity-Dependent Increase of AHP Amplitude in Leech T Sensory Neurons
J Neurophysiol, August 1, 2005; 94(2): 1066 - 1073.
[Abstract] [Full Text] [PDF]
E. L. Bartlett and X. Wang
Long-Lasting Modulation by Stimulus Context in Primate Auditory Cortex
J Neurophysiol, July 1, 2005; 94(1): 83 - 104.
[Abstract] [Full Text] [PDF]
L. G. Nowak, M. V. Sanchez-Vives, and D. A. McCormick
Role of Synaptic and Intrinsic Membrane Properties in Short-Term Receptive Field Dynamics in Cat Area 17
J. Neurosci., February 16, 2005; 25(7): 1866 - 1880.
[Abstract] [Full Text] [PDF]
V. F. Descalzo, L. G. Nowak, J. C. Brumberg, D. A. McCormick, and M. V. Sanchez-Vives
Slow Adaptation in Fast-Spiking Neurons of Visual Cortex
J Neurophysiol, February 1, 2005; 93(2): 1111 - 1118.
[Abstract] [Full Text] [PDF]
K. A. Zaghloul, K. Boahen, and J. B. Demb
Contrast Adaptation in Subthreshold and Spiking Responses of Mammalian Y-Type Retinal Ganglion Cells
J. Neurosci., January 26, 2005; 25(4): 860 - 868.
[Abstract] [Full Text] [PDF]
N. Ulanovsky, L. Las, D. Farkas, and I. Nelken
Multiple Time Scales of Adaptation in Auditory Cortex Neurons
J. Neurosci., November 17, 2004; 24(46): 10440 - 10453.
[Abstract] [Full Text] [PDF]
G. La Camera, A. Rauch, H.-R. Luscher, W. Senn, and S. Fusi
Minimal Models of Adapted Neuronal Response to In Vivo-Like Input Currents
Neural Comput., October 1, 2004; 16(10): 2101 - 2124.
[Abstract] [Full Text] [PDF]
J. M. Amigo, J. Szczepanski, E. Wajnryb, and M. V. Sanchez-Vives
Estimating the Entropy Rate of Spike Trains via Lempel-Ziv Complexity
Neural Comput., April 1, 2004; 16(4): 717 - 736.
[Abstract] [Full Text] [PDF]
J. Reutimann, V. Yakovlev, S. Fusi, and W. Senn
Climbing Neuronal Activity as an Event-Based Cortical Representation of Time
J. Neurosci., March 31, 2004; 24(13): 3295 - 3303.
[Abstract] [Full Text] [PDF]
C. L. Passaglia and J. B. Troy
Information Transmission Rates of Cat Retinal Ganglion Cells
J Neurophysiol, March 1, 2004; 91(3): 1217 - 1229.
[Abstract] [Full Text] [PDF]
J. Benda and A. V. M. Herz
A Universal Model for Spike-Frequency Adaptation
Neural Comput., November 1, 2003; 15(11): 2523 - 2564.
[Abstract] [Full Text] [PDF]
C. E. Garabedian, S. R. Jones, M. M. Merzenich, A. Dale, and C. I. Moore
Band-Pass Response Properties of Rat SI Neurons
J Neurophysiol, September 1, 2003; 90(3): 1379 - 1391.
[Abstract] [Full Text] [PDF]
A. Rauch, G. La Camera, H.-R. Luscher, W. Senn, and S. Fusi
Neocortical Pyramidal Cells Respond as Integrate-and-Fire Neurons to In Vivo-Like Input Currents
J Neurophysiol, September 1, 2003; 90(3): 1598 - 1612.
[Abstract] [Full Text] [PDF]
X.-J. Wang, Y. Liu, M. V. Sanchez-Vives, and D. A. McCormick
Adaptation and Temporal Decorrelation by Single Neurons in the Primary Visual Cortex
J Neurophysiol, June 1, 2003; 89(6): 3279 - 3293.
[Abstract] [Full Text] [PDF]
A. Compte, M. V. Sanchez-Vives, D. A. McCormick, and X.-J. Wang
Cellular and Network Mechanisms of Slow Oscillatory Activity (<1 Hz) and Wave Propagations in a Cortical Network Model
J Neurophysiol, May 1, 2003; 89(5): 2707 - 2725.
[Abstract] [Full Text] [PDF]
S. Franceschetti, T. Lavazza, G. Curia, P. Aracri, F. Panzica, G. Sancini, G. Avanzini, and J. Magistretti
Na+-Activated K+ Current Contributes to Postexcitatory Hyperpolarization in Neocortical Intrinsically Bursting Neurons
J Neurophysiol, April 1, 2003; 89(4): 2101 - 2111.
[Abstract] [Full Text] [PDF]
K. J. Kim and F. Rieke
Slow Na+ Inactivation and Variance Adaptation in Salamander Retinal Ganglion Cells
J. Neurosci., February 15, 2003; 23(4): 1506 - 1516.
[Abstract] [Full Text] [PDF]
A. Kohn, C. Metz, M. A. Tommerdahl, and B. L. Whitsel
Stimulus-Evoked Modulation of Sensorimotor Pyramidal Neuron EPSPs
J Neurophysiol, December 1, 2002; 88(6): 3331 - 3347.
[Abstract] [Full Text] [PDF]
M. Carandini, D. J Heeger, and W. Senn
A Synaptic Explanation of Suppression in Visual Cortex
J. Neurosci., November 15, 2002; 22(22): 10053 - 10065.
[Abstract] [Full Text] [PDF]
R. Scuri, R. Mozzachiodi, and M. Brunelli
Activity-Dependent Increase of the AHP Amplitude in T Sensory Neurons of the Leech
J Neurophysiol, November 1, 2002; 88(5): 2490 - 2500.
[Abstract] [Full Text] [PDF]
B. J. Malone, B. H. Scott, and M. N. Semple
Context-Dependent Adaptive Coding of Interaural Phase Disparity in the Auditory Cortex of Awake Macaques
J. Neurosci., June 1, 2002; 22(11): 4625 - 4638.
[Abstract] [Full Text] [PDF]
C. Sekirnjak and S. du Lac
Intrinsic Firing Dynamics of Vestibular Nucleus Neurons
J. Neurosci., March 15, 2002; 22(6): 2083 - 2095.
[Abstract] [Full Text] [PDF]
D. Chander and E. J. Chichilnisky
Adaptation to Temporal Contrast in Primate and Salamander Retina
J. Neurosci., December 15, 2001; 21(24): 9904 - 9916.
[Abstract] [Full Text] [PDF]
G. J. Murphy and S. Du Lac
Postnatal Development of Spike Generation in Rat Medial Vestibular Nucleus Neurons
J Neurophysiol, May 1, 2001; 85(5): 1899 - 1906.
[Abstract] [Full Text] [PDF]
K. J. Kim and F. Rieke
Temporal Contrast Adaptation in the Input and Output Signals of Salamander Retinal Ganglion Cells
J. Neurosci., January 1, 2001; 21(1): 287 - 299.
[Abstract] [Full Text] [PDF]
F. Gabbiani, C. Mo, and G. Laurent
Invariance of Angular Threshold Computation in a Wide-Field Looming-Sensitive Neuron
J. Neurosci., January 1, 2001; 21(1): 314 - 329.
[Abstract] [Full Text] [PDF]
M. V. Sanchez-Vives, L. G. Nowak, and D. A. McCormick
Membrane Mechanisms Underlying Contrast Adaptation in Cat Area 17 In Vivo
J. Neurosci., June 1, 2000; 20(11): 4267 - 4285.
[Abstract] [Full Text] [PDF]
L. M. Martinez, J.-M. Alonso, R. C. Reid, and J. A. Hirsch
Laminar processing of stimulus orientation in cat visual cortex
J. Physiol., April 1, 2002; 540(1): 321 - 333.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|