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Previous Article | Next Article
Medial Frontal Cortex Mediates Perceptual Attentional Set Shifting in the Rat
Jennifer M. Birrell and Verity J. Brown School of Psychology, University of St. Andrews, St. Andrews KY16 9JU, Scotland, United Kingdom
If rodents do not display the behavioral complexity that is subserved in primates by prefrontal cortex, then evolution of prefrontal cortex in the rat should be doubted. Primate prefrontal cortex has been shown to mediate shifts in attention between perceptual dimensions of complex stimuli. This study examined the possibility that medial frontal cortex of the rat is involved in the shifting of perceptual attentional set. We trained rats to perform an attentional set-shifting task that is formally the same as a task used in monkeys and humans. Rats were trained to dig in bowls for a food reward. The bowls were presented in pairs, only one of which was baited. The rat had to select the bowl in which to dig by its odor, the medium that filled the bowl, or the texture that covered its surface. In a single session, rats performed a series of discriminations, including reversals, an intradimensional shift, and an extradimensional shift.
Bilateral lesions by injection of ibotenic acid in medial frontal cortex resulted in impairment in neither initial acquisition nor reversal learning. We report here the same selective impairment in shifting of attentional set in the rat as seen in primates with lesions of prefrontal cortex. We conclude that medial frontal cortex of the rat has functional similarity to primate lateral prefrontal cortex.
Key words: attention; set shifting; prefrontal cortex; Cg3; prelimbic cortex; rat
Copyright © 2000 Society for Neuroscience 0270-6474/00/20114320-05$05.00/0
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