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Mutations of the Caenorhabditis elegans Brain-Specific Inorganic Phosphate Transporter eat-4 Affect Habituation of the Tap-Withdrawal Response without Affecting the Response Itself

Catharine H. Rankin² and Stephen R. Wicks¹

¹ Program in Neuroscience and ² Department of Psychology, University of British Columbia, Vancouver, British Columbia V6T-1Z4, Canada

The studies reported here were designed to investigate the role of the mutation eat-4 in the response to tap and in habituation in the nematode Caenorhabditis elegans. In C. elegans eat-4 has been found to affect a number of glutamatergic pathways. It has been hypothesized to positively regulate glutaminase activity and therefore glutamatergic neurotransmission. In the eat-4(ky5) loss-of-function worms, there is presumably insufficient glutamate available for sustained transmission. In the experiments reported here eat-4 worms showed no differences from wild-type in the magnitude of response to a single tap, indicating that the neural circuit underlying the response was intact and functional in the mutant worms. However, when eat-4 worms were given repeated taps the resulting habituation was different from that seen in wild-type worms: eat-4 worms habituate more rapidly and recover more slowly than wild-type worms at all interstimulus intervals tested. In addition, eat-4 worms do not show dishabituation. The same transgene rescues pharyngeal activity defects and both the habituation and dishabituation deficits seen in the eat-4 worms. Our results suggest that neurotransmitter regulation plays a role in habituation and may play a role in dishabituation.

Key words: C. elegans; habituation; invertebrate learning; glutamate; behavior genetics; sodium dependent inorganic phosphate co-transporter

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Copyright © 2000 Society for Neuroscience  0270-6474/00/20114337-08$05.00/0

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