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The Journal of Neuroscience, July 1, 2000, 20(13):4885-4889
A Temperature-Sensitive Paralytic Mutant Defines a Primary Synaptic Calcium Channel in Drosophila
Fumiko Kawasaki, Ryan Felling, and Richard W. Ordway Department of Biology, The Pennsylvania State University, University Park, Pennsylvania 16802
Neurotransmission at chemical synapses involves regulated exocytosis of neurotransmitter from the presynaptic terminal. Neurotransmitter release is thought to be triggered by calcium influx through specific classes of voltage-gated calcium channels. Here we report genetic and functional analysis implicating a specific calcium channel gene product in neurotransmitter release. We have isolated a temperature-sensitive paralytic allele of the Drosophila calcium channel
1 subunit gene, cacophony (cac). This mutant, referred to as cacTS2, allows functional analysis of synaptic transmission after acute perturbation of a specific
Key words: calcium channel; neurotransmitter release; synaptic transmission; cacophony; Drosophila; temperature-sensitive
Copyright © 2000 Society for Neuroscience 0270-6474/00/20134885-05$05.00/0
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