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The Journal of Neuroscience, July 1, 2000, 20(13):4890-4903
Rectification and Rapid Activation at Low Ca2+ of Ca2+-Activated, Voltage-Dependent BK Currents: Consequences of Rapid Inactivation by a Novel
Subunit
Xiao-Ming Xia, Jiu-Ping Ding, Xu-Hui Zeng, Kai-Lai Duan, and Christopher J. Lingle Washington University School of Medicine, Departments of Anesthesiology, and Anatomy and Neurobiology, St. Louis, Missouri 63110
A family of accessory
subunits significantly contributes to the functional diversity of large-conductance, Ca2+- and voltage-dependent potassium (BK) channels in native cells. Here we describe the functional properties of one variant of the
subunits results in rectifying outward currents and, at more positive potentials, rapidly inactivating (~1 msec) currents. The underlying rapid inactivation process results in an increase in the apparent activation rate of macroscopic currents, which is coupled with a shift in the activation range of the currents at low Ca2+. As a consequence, the currents exhibit more rapid activation at low Ca2+ relative to any other BK channel subunit combinations that have been examined. In part because of the rapid inactivation process, single channel openings are exceedingly brief. Although variance analysis suggests a conductance in excess of 160 pS, fully resolved single channel openings are not observed. The inactivation process results from a cytosolic N-terminal domain of the
Key words: accessory subunits; K+ channels; BK channels; Ca2+- and voltage-gated K+ channels; mSlo channels; inactivation
Copyright © 2000 Society for Neuroscience 0270-6474/00/20134890-14$05.00/0
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