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The Journal of Neuroscience, July 1, 2000, 20(13):4912-4921
Active Zones on Motor Nerve Terminals Contain  3 1
Integrin
Monroe W.
Cohen1,
Benjamin G.
Hoffstrom2, and
Douglas W.
DeSimone2
1 Department of Physiology, McGill University,
Montreal, Quebec Canada H3G 1Y6, and 2 Department of Cell
Biology, University of Virginia, Charlottesville, Virginia 22908
Active zones are the sites along nerve terminals where synaptic
vesicles dock and undergo calcium-dependent exocytosis during synaptic
transmission. Here we show, by immunofluorescent staining with
antibodies generated against Xenopus laevis integrins,
that  3 1 integrin is concentrated at the active zones of
Xenopus motor nerve terminals. Because integrins can
link extracellular matrix molecules to cytoskeletal elements and
participate in the formation of signaling complexes, the localization
of integrin at active zones suggests that it may play a role in the
adhesion of the nerve terminals to the synaptic basal lamina, in the
formation and maintenance of active zones, and in some of the events
associated with calcium-dependent exocytosis of neurotransmitter. Our
findings also indicate that the integrin composition of the terminal
Schwann cells differs from that of the motor nerve terminals, and this may account at least in part for differences in their adhesiveness to
the synaptic basal lamina.
Key words:
active zones; 31 integrin; motor nerve terminals; terminal Schwann cells; Xenopus laevis; neuromuscular
junction; neurotransmitter release
Copyright © 2000 Society for Neuroscience 0270-6474/00/20134912-10$05.00/0
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