 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, July 1, 2000, 20(13):5012-5023
Basic Fibroblast Growth Factor (Fgf2) Is Necessary for Cell Proliferation and Neurogenesis in the Developing Cerebral Cortex
Rossana Raballo1, Julianne Rhee1, Richard Lyn-Cook1, James F. Leckman1, Michael L. Schwartz2, and Flora M. Vaccarino1, 2 1 Child Study Center and 2 Section of Neurobiology, Yale University, New Haven, Connecticut 06520
Little is known about regionally specific signals that control the number of neuronal progenitor cells in vivo. We have previously shown that the germline mutation of the basic fibroblast growth factor (Fgf2) gene results in a reduction in the number of cortical neurons in the adult. We show here that Fgf2 is expressed in the pseudostratified ventricular epithelium (PVE) in a dorsoventral gradient and that Fgf2 and its receptor, Fgfr-1, are downregulated by mid to late stages of neurogenesis. In Fgf2 knockout mice, the volume and cell number of the dorsal PVE (the cerebral cortical anlage) are substantially smaller, whereas the volume of the basal PVE is unchanged. The dorsal PVE of Fgf2 knockout mice has a 50% decrease in founder cells and a reduced expansion of the progenitor pool over the first portion of neurogenesis. Despite this reduction, the degree of apoptosis within the PVE is not changed in the Fgf2 knockouts. Cortical neuron number was decreased by 45% in Fgf2 knockout mice by the end of neurogenesis, whereas the number of neurons in the basal ganglia was unaffected. Microscopically, the frontal cerebral cortex of neonatal Fgf2 null mutant mice lacked large neurons in deep cortical layers. We suggest that Fgf2 is required for the generation of a specific class of cortical neurons arising from the dorsal PVE.
Key words: fibroblast growth factor; Fgf2; knockout; null mutation; gene; neurogenesis; mouse; pseudostratified ventricular epithelium; apoptosis; cell division; neuronal progenitor; cerebral cortex; basal ganglia
Copyright © 2000 Society for Neuroscience 0270-6474/00/20135012-12$05.00/0
This article has been cited by other articles:
X. Li, B. Z. Barkho, Y. Luo, R. D. Smrt, N. J. Santistevan, C. Liu, T. Kuwabara, F. H. Gage, and X. Zhao
Epigenetic Regulation of the Stem Cell Mitogen Fgf-2 by Mbd1 in Adult Neural Stem/Progenitor Cells
J. Biol. Chem., October 10, 2008; 283(41): 27644 - 27652.
[Abstract] [Full Text] [PDF]
A. Faedo, G. S. Tomassy, Y. Ruan, H. Teichmann, S. Krauss, S. J. Pleasure, S. Y. Tsai, M.-J. Tsai, M. Studer, and J. L. R. Rubenstein
COUP-TFI Coordinates Cortical Patterning, Neurogenesis, and Laminar Fate and Modulates MAPK/ERK, AKT, and ss-Catenin Signaling
Cereb Cortex, September 1, 2008; 18(9): 2117 - 2131.
[Abstract] [Full Text] [PDF]
K. Akita, A. von Holst, Y. Furukawa, T. Mikami, K. Sugahara, and A. Faissner
Expression of Multiple Chondroitin/Dermatan Sulfotransferases in the Neurogenic Regions of the Embryonic and Adult Central Nervous System Implies That Complex Chondroitin Sulfates Have a Role in Neural Stem Cell Maintenance
Stem Cells, March 1, 2008; 26(3): 798 - 809.
[Abstract] [Full Text] [PDF]
Y. Ke, E. E. Zhang, K. Hagihara, D. Wu, Y. Pang, R. Klein, T. Curran, B. Ranscht, and G.-S. Feng
Deletion of Shp2 in the Brain Leads to Defective Proliferation and Differentiation in Neural Stem Cells and Early Postnatal Lethality
Mol. Cell. Biol., October 1, 2007; 27(19): 6706 - 6717.
[Abstract] [Full Text] [PDF]
D. Maric, A. Fiorio Pla, Y. H. Chang, and J. L. Barker
Self-Renewing and Differentiating Properties of Cortical Neural Stem Cells Are Selectively Regulated by Basic Fibroblast Growth Factor (FGF) Signaling via Specific FGF Receptors
J. Neurosci., February 21, 2007; 27(8): 1836 - 1852.
[Abstract] [Full Text] [PDF]
T. Yoshimatsu, D. Kawaguchi, K. Oishi, K. Takeda, S. Akira, N. Masuyama, and Y. Gotoh
Non-cell-autonomous action of STAT3 in maintenance of neural precursor cells in the mouse neocortex
Development, July 1, 2006; 133(13): 2553 - 2563.
[Abstract] [Full Text] [PDF]
A. Paquin, F. Barnabe-Heider, R. Kageyama, and F. D. Miller
CCAAT/Enhancer-Binding Protein Phosphorylation Biases Cortical Precursors to Generate Neurons Rather Than Astrocytes In Vivo
J. Neurosci., November 16, 2005; 25(46): 10747 - 10758.
[Abstract] [Full Text] [PDF]
S. Yamamoto, I. Yoshino, T. Shimazaki, M. Murohashi, R. F. Hevner, I. Lax, H. Okano, M. Shibuya, J. Schlessinger, and N. Gotoh
Essential role of Shp2-binding sites on FRS2{alpha} for corticogenesis and for FGF2-dependent proliferation of neural progenitor cells
PNAS, November 1, 2005; 102(44): 15983 - 15988.
[Abstract] [Full Text] [PDF]
K. Grobe, M. Inatani, S. R. Pallerla, J. Castagnola, Y. Yamaguchi, and J. D. Esko
Cerebral hypoplasia and craniofacial defects in mice lacking heparan sulfate Ndst1 gene function
Development, August 15, 2005; 132(16): 3777 - 3786.
[Abstract] [Full Text] [PDF]
D. J. Bharali, I. Klejbor, E. K. Stachowiak, P. Dutta, I. Roy, N. Kaur, E. J. Bergey, P. N. Prasad, and M. K. Stachowiak
Organically modified silica nanoparticles: A nonviral vector for in vivo gene delivery and expression in the brain
PNAS, August 9, 2005; 102(32): 11539 - 11544.
[Abstract] [Full Text] [PDF]
R. Narasimhaiah, A. Tuchman, S. L. Lin, and J. R. Naegele
Oxidative Damage and Defective DNA Repair is Linked to Apoptosis of Migrating Neurons and Progenitors During Cerebral Cortex Development in Ku70-Deficient Mice
Cereb Cortex, June 1, 2005; 15(6): 696 - 707.
[Abstract] [Full Text] [PDF]
A. F. Pla, D. Maric, S.-C. Brazer, P. Giacobini, X. Liu, Y. H. Chang, I. S. Ambudkar, and J. L. Barker
Canonical Transient Receptor Potential 1 Plays a Role in Basic Fibroblast Growth Factor (bFGF)/FGF Receptor-1-Induced Ca2+ Entry and Embryonic Rat Neural Stem Cell Proliferation
J. Neurosci., March 9, 2005; 25(10): 2687 - 2701.
[Abstract] [Full Text] [PDF]
C. Gregg and S. Weiss
CNTF/LIF/gp130 receptor complex signaling maintains a VZ precursor differentiation gradient in the developing ventral forebrain
Development, February 1, 2005; 132(3): 565 - 578.
[Abstract] [Full Text] [PDF]
L. Zhang, J. Bai, A. S. Undie, C. Bergson, and M. S. Lidow
D1 Dopamine Receptor Regulation of the Levels of the Cell-cycle-controlling Proteins, Cyclin D, P27 and Raf-1, in Cerebral Cortical Precursor Cells is Mediated Through cAMP-independent Pathways
Cereb Cortex, January 1, 2005; 15(1): 74 - 84.
[Abstract] [Full Text] [PDF]
E. Garcion, A. Halilagic, A. Faissner, and C. ffrench-Constant
Generation of an environmental niche for neural stem cell development by the extracellular matrix molecule tenascin C
Development, July 15, 2004; 131(14): 3423 - 3432.
[Abstract] [Full Text] [PDF]
Y. Ohkubo, A. O. Uchida, D. Shin, J. Partanen, and F. M. Vaccarino
Fibroblast Growth Factor Receptor 1 Is Required for the Proliferation of Hippocampal Progenitor Cells and for Hippocampal Growth in Mouse
J. Neurosci., July 7, 2004; 24(27): 6057 - 6069.
[Abstract] [Full Text] [PDF]
D. M. Shin, S. Korada, R. Raballo, C. S. Shashikant, A. Simeone, J. R. Taylor, and F. Vaccarino
Loss of Glutamatergic Pyramidal Neurons in Frontal and Temporal Cortex Resulting from Attenuation of FGFR1 Signaling Is Associated with Spontaneous Hyperactivity in Mice
J. Neurosci., March 3, 2004; 24(9): 2247 - 2258.
[Abstract] [Full Text] [PDF]
S. S. Newton, E. F. Collier, J. Hunsberger, D. Adams, R. Terwilliger, E. Selvanayagam, and R. S. Duman
Gene Profile of Electroconvulsive Seizures: Induction of Neurotrophic and Angiogenic Factors
J. Neurosci., November 26, 2003; 23(34): 10841 - 10851.
[Abstract] [Full Text] [PDF]
A. Gulacsi and L. Lillien
Sonic Hedgehog and Bone Morphogenetic Protein Regulate Interneuron Development from Dorsal Telencephalic Progenitors In Vitro
J. Neurosci., October 29, 2003; 23(30): 9862 - 9872.
[Abstract] [Full Text] [PDF]
F. Barnabe-Heider and F. D. Miller
Endogenously Produced Neurotrophins Regulate Survival and Differentiation of Cortical Progenitors via Distinct Signaling Pathways
J. Neurosci., June 15, 2003; 23(12): 5149 - 5160.
[Abstract] [Full Text] [PDF]
Q. Xu, E. de la Cruz, and S. A. Anderson
Cortical Interneuron Fate Determination: Diverse Sources for Distinct Subtypes?
Cereb Cortex, June 1, 2003; 13(6): 670 - 676.
[Abstract] [Full Text] [PDF]
N. Matsuoka, K. Nozaki, Y. Takagi, M. Nishimura, J. Hayashi, S.-I. Miyatake, and N. Hashimoto
Adenovirus-Mediated Gene Transfer of Fibroblast Growth Factor-2 Increases BrdU-Positive Cells After Forebrain Ischemia in Gerbils
Stroke, June 1, 2003; 34(6): 1519 - 1525.
[Abstract] [Full Text] [PDF]
R. Dono
Fibroblast growth factors as regulators of central nervous system development and function
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2003; 284(4): R867 - R881.
[Abstract] [Full Text] [PDF]
J. M. Hebert, M. Lin, J. Partanen, J. Rossant, and S. K. McConnell
FGF signaling through FGFR1 is required for olfactory bulb morphogenesis
Development, March 15, 2003; 130(6): 1101 - 1111.
[Abstract] [Full Text] [PDF]
A. Facchiano, K. Russo, A. M. Facchiano, F. De Marchis, F. Facchiano, D. Ribatti, M. S. Aguzzi, and M. C. Capogrossi
Identification of a Novel Domain of Fibroblast Growth Factor 2 Controlling Its Angiogenic Properties
J. Biol. Chem., February 28, 2003; 278(10): 8751 - 8760.
[Abstract] [Full Text] [PDF]
M. Ford-Perriss, S. E. Guimond, U. Greferath, M. Kita, K. Grobe, H. Habuchi, K. Kimata, J. D. Esko, M. Murphy, and J. E. Turnbull
Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling
Glycobiology, November 1, 2002; 12(11): 721 - 727.
[Abstract] [Full Text] [PDF]
R. C. Armstrong, T. Q. Le, E. E. Frost, R. C. Borke, and A. C. Vana
Absence of Fibroblast Growth Factor 2 Promotes Oligodendroglial Repopulation of Demyelinated White Matter
J. Neurosci., October 1, 2002; 22(19): 8574 - 8585.
[Abstract] [Full Text] [PDF]
A. Lukaszewicz, P. Savatier, V. Cortay, H. Kennedy, and C. Dehay
Contrasting Effects of Basic Fibroblast Growth Factor and Neurotrophin 3 on Cell Cycle Kinetics of Mouse Cortical Stem Cells
J. Neurosci., August 1, 2002; 22(15): 6610 - 6622.
[Abstract] [Full Text] [PDF]
A. Mallei, B. Shi, and I. Mocchetti
Antidepressant Treatments Induce the Expression of Basic Fibroblast Growth Factor in Cortical and Hippocampal Neurons
Mol. Pharmacol., May 1, 2002; 61(5): 1017 - 1024.
[Abstract] [Full Text] [PDF]
S. Korada, W. Zheng, C. Basilico, M. L. Schwartz, and F. M. Vaccarino
Fibroblast Growth Factor 2 Is Necessary for the Growth of Glutamate Projection Neurons in the Anterior Neocortex
J. Neurosci., February 1, 2002; 22(3): 863 - 875.
[Abstract] [Full Text] [PDF]
G. Szebenyi, E. W. Dent, J. L. Callaway, C. Seys, H. Lueth, and K. Kalil
Fibroblast Growth Factor-2 Promotes Axon Branching of Cortical Neurons by Influencing Morphology and Behavior of the Primary Growth Cone
J. Neurosci., June 1, 2001; 21(11): 3932 - 3941.
[Abstract] [Full Text] [PDF]
L Lillien and H Raphael
BMP and FGF regulate the development of EGF-responsive neural progenitor cells
Development, January 11, 2000; 127(22): 4993 - 5005.
[Abstract] [PDF]
|
|
|
|
 |
|