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The Journal of Neuroscience, July 1, 2000, 20(13):5179-5189
Changes in Functional Connectivity in Orbitofrontal Cortex and
Basolateral Amygdala during Learning and Reversal Training
Geoffrey
Schoenbaum1,
Andrea A.
Chiba2, and
Michela
Gallagher1
1 Department of Psychology, Johns Hopkins University,
Baltimore, Maryland 21218, and 2 Cognitive Science
Department, University of California at San Diego, La Jolla, CA 92093
Interconnections between orbitofrontal cortex (OFC) and basolateral
amygdala (ABL) are critical for encoding and using associative information about the motivational significance of stimuli. Previously, we reported that neurons in OFC and ABL fired selectively to cues during odor discrimination learning and reversal training. Here we
conducted an analysis of correlated firing in the cell pairs recorded
in the previous study. Correlated firing during the intertrial intervals was compared across task phases during different phases of
acquisition and reversal learning. Changes in correlated activity during initial learning and subsequent accurate performance on the
discrimination problems closely resembled the changes in odor selectivity in OFC and ABL reported earlier. Increased correlated firing was most pronounced in OFC during accurate go, no-go performance in the postcriterion phase of performance, whereas correlated firing in
ABL increased primarily during an earlier phase of learning. In
contrast, findings during subsequent reversal training diverged from
our earlier report in which odor selectivity diminished in OFC and
reversed in ABL. When the reinforcement contingencies of the odors were
reversed after the rat had learned the original associations,
correlated firing further increased significantly in OFC but remained
stable in ABL. This evidence that associative encoding increments with
reversal learning in OFC suggests that the original associations,
although not expressed as stimulus driven activity, may be
maintained within the network as new associations are acquired.
Key words:
orbitofrontal; basolateral amygdala; prefrontal; agranular insular; olfactory; cross-correlation; functional
connectivity; electrophysiology; learning and memory
Copyright © 2000 Society for Neuroscience 0270-6474/00/20135179-11$05.00/0
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