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The Journal of Neuroscience, 0000, 20:RC83:1-5

RAPID COMMUNICATION
The Basic Helix-Loop-Helix-PAS Protein MOP9 Is a Brain-Specific Heterodimeric Partner of Circadian and Hypoxia Factors

John B. Hogenesch¹, Yi-Zhong Gu¹, Susan M. Moran¹, Kazuhiro Shimomura², Laurel A. Radcliffe², Joseph S. Takahashi², and Christopher A. Bradfield¹

¹ The McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, Madison, Wisconsin 53706, and ² The Howard Hughes Medical Institute, Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208-3520

PAS (PER, ARNT, SIM) proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. In an attempt to better understand how organisms sense environmental changes, we have characterized a novel member of the PAS superfamily, MOP9 (member of PAS superfamily), that maps to human chromosome 12p11.22-11.23. This protein displays significant homology to the Drosophila circadian factor CYCLE and its putative mammalian ortholog MOP3/bMAL1. Like its homologs, MOP9 forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1. In a manner consistent with its role as a biologically relevant partner of these proteins, MOP9 is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Importantly, MOP9 is coexpressed with CLOCK in the suprachiasmatic nucleus, the site of the master circadian oscillator in mammals.

Key words: MOP9; bHLH-PAS; circadian; hypoxia; transcription factor; heterodimer; SCN

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Copyright © 0000 Society for Neuroscience  0270-6474/00/$05.00/0

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