 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, July 15, 2000, 20(14):5208-5216
Long-Term Potentiation of Intrinsic Excitability at the Mossy Fiber-Granule Cell Synapse of Rat Cerebellum
S. Armano1, P. Rossi1, V. Taglietti1, and E. D'Angelo1, 2 1 Department of Cellular/Molecular Physiology and Pharmacology, and INFM (Pavia Unit), I-27100 Pavia, Italy, and 2 Department of Functional and Evolutive Biology, Parco Area delle Scienze 11A, I-43100 Parma, Italy
Synaptic activity can induce persistent modifications in the way a neuron reacts to subsequent inputs by changing either synaptic efficacy or intrinsic excitability. After high-frequency synaptic stimulation, long-term potentiation (LTP) of synaptic efficacy is commonly observed at hippocampal synapses (Bliss and Collingridge, 1993), and potentiation of intrinsic excitability has recently been reported in cerebellar deep nuclear neurons (Aizenmann and Linden, 2000). However, the potential coexistence of these two aspects of plasticity remained unclear. In this paper we have investigated the effect of high-frequency stimulation on synaptic transmission and intrinsic excitability at the mossy fiber-granule cell relay of the cerebellum. High-frequency stimulation, in addition to increasing synaptic conductance (D'Angelo et al., 1999), increased granule cell input resistance and decreased spike threshold. These changes depended on postsynaptic depolarization and NMDA receptor activation and were prevented by inhibitory synaptic activity. Potentiation of intrinsic excitability was induced by relatively weaker inputs than potentiation of synaptic efficacy, whereas with stronger inputs the two aspect of potentiation combined to enhance EPSPs and spike generation. Potentiation of intrinsic excitability may extend the computational capability of the cerebellar mossy fiber-granule cell relay.
Key words: synaptic plasticity; LTP; NMDA receptors; cerebellum; granule cells; intrinsic excitability; E-S potentiation
Copyright © 2000 Society for Neuroscience 0270-6474/00/20145208-09$05.00/0
This article has been cited by other articles:
F. Prestori, P. Rossi, B. Bearzatto, J. Laine, D. Necchi, S. Diwakar, S. N. Schiffmann, H. Axelrad, and E. D'Angelo
Altered Neuron Excitability and Synaptic Plasticity in the Cerebellar Granular Layer of Juvenile Prion Protein Knock-Out Mice with Impaired Motor Control
J. Neurosci., July 9, 2008; 28(28): 7091 - 7103.
[Abstract] [Full Text] [PDF]
L. Roggeri, B. Rivieccio, P. Rossi, and E. D'Angelo
Tactile Stimulation Evokes Long-Term Synaptic Plasticity in the Granular Layer of Cerebellum
J. Neurosci., June 18, 2008; 28(25): 6354 - 6359.
[Abstract] [Full Text] [PDF]
E. Santini, G. J. Quirk, and J. T. Porter
Fear Conditioning and Extinction Differentially Modify the Intrinsic Excitability of Infralimbic Neurons
J. Neurosci., April 9, 2008; 28(15): 4028 - 4036.
[Abstract] [Full Text] [PDF]
P. J. Sjostrom, E. A. Rancz, A. Roth, and M. Hausser
Dendritic Excitability and Synaptic Plasticity
Physiol Rev, April 1, 2008; 88(2): 769 - 840.
[Abstract] [Full Text] [PDF]
E. Campanac and D. Debanne
Spike timing-dependent plasticity: a learning rule for dendritic integration in rat CA1 pyramidal neurons
J. Physiol., February 1, 2008; 586(3): 779 - 793.
[Abstract] [Full Text] [PDF]
J. Mapelli and E. D'Angelo
The Spatial Organization of Long-Term Synaptic Plasticity at the Input Stage of Cerebellum
J. Neurosci., February 7, 2007; 27(6): 1285 - 1296.
[Abstract] [Full Text] [PDF]
D. J. Schulz
Plasticity and stability in neuronal output via changes in intrinsic excitability: it's what's inside that counts
J. Exp. Biol., December 15, 2006; 209(24): 4821 - 4827.
[Abstract] [Full Text] [PDF]
E. Carlier, V. Sourdet, S. Boudkkazi, P. Deglise, N. Ankri, L. Fronzaroli-Molinieres, and D. Debanne
Metabotropic glutamate receptor subtype 1 regulates sodium currents in rat neocortical pyramidal neurons
J. Physiol., November 15, 2006; 577(1): 141 - 154.
[Abstract] [Full Text] [PDF]
Y. Dan and M.-M. Poo
Spike timing-dependent plasticity: from synapse to perception.
Physiol Rev, July 1, 2006; 86(3): 1033 - 1048.
[Abstract] [Full Text] [PDF]
T. Nieus, E. Sola, J. Mapelli, E. Saftenku, P. Rossi, and E. D'Angelo
LTP Regulates Burst Initiation and Frequency at Mossy Fiber-Granule Cell Synapses of Rat Cerebellum: Experimental Observations and Theoretical Predictions
J Neurophysiol, February 1, 2006; 95(2): 686 - 699.
[Abstract] [Full Text] [PDF]
D. Gall, F. Prestori, E. Sola, A. D'Errico, C. Roussel, L. Forti, P. Rossi, and E. D'Angelo
Intracellular Calcium Regulation by Burst Discharge Determines Bidirectional Long-Term Synaptic Plasticity at the Cerebellum Input Stage
J. Neurosci., May 11, 2005; 25(19): 4813 - 4822.
[Abstract] [Full Text] [PDF]
J. Xu, N. Kang, L. Jiang, M. Nedergaard, and J. Kang
Activity-Dependent Long-Term Potentiation of Intrinsic Excitability in Hippocampal CA1 Pyramidal Neurons
J. Neurosci., February 16, 2005; 25(7): 1750 - 1760.
[Abstract] [Full Text] [PDF]
W. Zhang, J. H. Shin, and D. J Linden
Persistent changes in the intrinsic excitability of rat deep cerebellar nuclear neurones induced by EPSP or IPSP bursts
J. Physiol., December 15, 2004; 561(3): 703 - 719.
[Abstract] [Full Text] [PDF]
M. Maravall, E. A. Stern, and K. Svoboda
Development of Intrinsic Properties and Excitability of Layer 2/3 Pyramidal Neurons During a Critical Period for Sensory Maps in Rat Barrel Cortex
J Neurophysiol, July 1, 2004; 92(1): 144 - 156.
[Abstract] [Full Text] [PDF]
R. H. Cudmore and G. G. Turrigiano
Long-Term Potentiation of Intrinsic Excitability in LV Visual Cortical Neurons
J Neurophysiol, July 1, 2004; 92(1): 341 - 348.
[Abstract] [Full Text] [PDF]
E. Sola, F. Prestori, P. Rossi, V. Taglietti, and E. D'Angelo
Increased neurotransmitter release during long-term potentiation at mossy fibre-granule cell synapses in rat cerebellum
J. Physiol., June 15, 2004; 557(3): 843 - 861.
[Abstract] [Full Text] [PDF]
V. Sourdet, M. Russier, G. Daoudal, N. Ankri, and D. Debanne
Long-Term Enhancement of Neuronal Excitability and Temporal Fidelity Mediated by Metabotropic Glutamate Receptor Subtype 5
J. Neurosci., November 12, 2003; 23(32): 10238 - 10248.
[Abstract] [Full Text] [PDF]
G. Daoudal and D. Debanne
Long-Term Plasticity of Intrinsic Excitability: Learning Rules and Mechanisms
Learn. Mem., November 1, 2003; 10(6): 456 - 465.
[Abstract] [Full Text] [PDF]
D. Gall, C. Roussel, I. Susa, E. D'Angelo, P. Rossi, B. Bearzatto, M. C. Galas, D. Blum, S. Schurmans, and S. N. Schiffmann
Altered Neuronal Excitability in Cerebellar Granule Cells of Mice Lacking Calretinin
J. Neurosci., October 15, 2003; 23(28): 9320 - 9327.
[Abstract] [Full Text] [PDF]
C. A. Scudder and D. M. McGee
Adaptive Modification of Saccade Size Produces Correlated Changes in the Discharges of Fastigial Nucleus Neurons
J Neurophysiol, August 1, 2003; 90(2): 1011 - 1026.
[Abstract] [Full Text] [PDF]
C. A. SCUDDER
Role of the Fastigial Nucleus in Controlling Horizontal Saccades during Adaptation
Ann. N.Y. Acad. Sci., December 1, 2002; 978(1): 63 - 78.
[Abstract] [Full Text] [PDF]
P. Rossi, E. Sola, V. Taglietti, T. Borchardt, F. Steigerwald, J. K. Utvik, O. P. Ottersen, G. Kohr, and E. D'Angelo
NMDA Receptor 2 (NR2) C-Terminal Control of NR Open Probability Regulates Synaptic Transmission and Plasticity at a Cerebellar Synapse
J. Neurosci., November 15, 2002; 22(22): 9687 - 9697.
[Abstract] [Full Text] [PDF]
G. Daoudal, Y. Hanada, and D. Debanne
Bidirectional plasticity of excitatory postsynaptic potential (EPSP)-spike coupling in CA1 hippocampal pyramidal neurons
PNAS, October 29, 2002; 99(22): 14512 - 14517.
[Abstract] [Full Text] [PDF]
A. Maffei, F. Prestori, P. Rossi, V. Taglietti, and E. D'Angelo
Presynaptic Current Changes at the Mossy Fiber-Granule Cell Synapse of Cerebellum During LTP
J Neurophysiol, August 1, 2002; 88(2): 627 - 638.
[Abstract] [Full Text] [PDF]
M. Ito
Cerebellar Long-Term Depression: Characterization, Signal Transduction, and Functional Roles
Physiol Rev, July 1, 2001; 81(3): 1143 - 1195.
[Abstract] [Full Text] [PDF]
A. M. MARINI, J. CHOI, and R. LABUTTA
Synaptic Deprivation and Age-Related Vulnerability to Hypoxic-Ischemic Neuronal Injury: A Hypothesis
Ann. N.Y. Acad. Sci., June 1, 2001; 939(1): 238 - 253.
[Abstract] [Full Text] [PDF]
B. D. Burrell, C. L. Sahley, and K. J. Muller
Non-Associative Learning and Serotonin Induce Similar Bi-Directional Changes in Excitability of a Neuron Critical for Learning in the Medicinal Leech
J. Neurosci., February 15, 2001; 21(4): 1401 - 1412.
[Abstract] [Full Text] [PDF]
E. D'Angelo, T. Nieus, A. Maffei, S. Armano, P. Rossi, V. Taglietti, A. Fontana, and G. Naldi
Theta-Frequency Bursting and Resonance in Cerebellar Granule Cells: Experimental Evidence and Modeling of a Slow K+-Dependent Mechanism
J. Neurosci., February 1, 2001; 21(3): 759 - 770.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|