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Previous Article | Next Article
The Journal of Neuroscience, July 15, 2000, 20(14):5329-5338
Small GTPases Rac and Rho in the Maintenance of Dendritic Spines and Branches in Hippocampal Pyramidal Neurons
Ann Y. Nakayama1, 2, Matthew B. Harms1, and Liqun Luo1, 2 1 Department of Biological Sciences and 2 Neurosciences Program, Stanford University, Stanford, California 94305-5020
The shape of dendritic trees and the density of dendritic spines can undergo significant changes during the life of a neuron. We report here the function of the small GTPases Rac and Rho in the maintenance of dendritic structures. Maturing pyramidal neurons in rat hippocampal slice culture were biolistically transfected with dominant GTPase mutants. We found that expression of dominant-negative Rac1 results in a progressive elimination of dendritic spines, whereas hyperactivation of RhoA causes a drastic simplification of dendritic branch patterns that is dependent on the activity of a downstream kinase ROCK. Our results suggest that Rac and Rho play distinct functions in regulating dendritic spines and branches and are vital for the maintenance and reorganization of dendritic structures in maturing neurons.
Key words: Rac; Rho; dendritic spines; biolistic transfection; pyramidal neurons; effector domain mutants; ROCK; Y-27632; PSD-95
Copyright © 2000 Society for Neuroscience 0270-6474/00/20145329-10$05.00/0
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Developmental expression of the fragile X-related 1 proteins in mouse testis: association with microtubule elements
Hum. Mol. Genet., November 1, 2001; 10(24): 2803 - 2811.
[Abstract] [Full Text] [PDF]
T. Yamasaki, K. Kawaji, K. Ono, H. Bito, T. Hirano, N. Osumi, and M. Kengaku
Pax6 regulates granule cell polarization during parallel fiber formation in the developing cerebellum
Development, August 15, 2001; 128(16): 3133 - 3144.
[Abstract] [Full Text] [PDF]
A. Schenck, B. Bardoni, A. Moro, C. Bagni, and J.-L. Mandel
A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P
PNAS, June 28, 2001; (2001) 151231598.
[Abstract] [Full Text] [PDF]
B. McEwen, K. Akama, S. Alves, W. G. Brake, K. Bulloch, S. Lee, C. Li, G. Yuen, and T. A. Milner
Tracking the estrogen receptor in neurons: Implications for estrogen-induced synapse formation
PNAS, June 19, 2001; 98(13): 7093 - 7100.
[Abstract] [Full Text] [PDF]
S. Martinez-Arca, S. Coco, G. Mainguy, U. Schenk, P. Alberts, P. Bouille, M. Mezzina, A. Prochiantz, M. Matteoli, D. Louvard, et al.
A Common Exocytotic Mechanism Mediates Axonal and Dendritic Outgrowth
J. Neurosci., June 1, 2001; 21(11): 3830 - 3838.
[Abstract] [Full Text] [PDF]
J. Bateman and D. Van Vactor
The Trio family of guanine-nucleotide-exchange factors: regulators of axon guidance
J. Cell Sci., January 6, 2001; 114(11): 1973 - 1980.
[Abstract] [Full Text] [PDF]
A. Schenck, B. Bardoni, A. Moro, C. Bagni, and J.-L. Mandel
A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P
PNAS, July 17, 2001; 98(15): 8844 - 8849.
[Abstract] [Full Text] [PDF]
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