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The Journal of Neuroscience, July 15, 2000, 20(14):5437-5448
Intrinsic and Extrinsic Contributions to Auditory Selectivity in
a Song Nucleus Critical for Vocal Plasticity
Merri J.
Rosen and
Richard
Mooney
Department of Neurobiology, Duke University Medical
Center, Durham, North Carolina 27710
The development, maintenance, and perception of learned
vocalizations in songbirds are likely to require auditory neurons that
respond selectively to song. Neurons with song-selective responses have
been described in several brain nuclei critical to singing, but the
mechanisms by which such response properties arise, are modified, and
propagate are poorly understood. The lateral magnocellular nucleus of
the anterior neostriatum (LMAN) is the output of an anterior forebrain
pathway (AFP) essential for learning and maintenance of song, processes
dependent on auditory feedback. Although neurons throughout this
pathway respond selectively to auditory presentation of the bird's own
song, LMAN is the last stage at which responses to this auditory
information could be transformed before being transmitted to vocal
motor areas, where such responses may influence vocal production.
Indeed, previous extracellular studies have indicated that LMAN's
auditory selectivity is greater than that at earlier stages of the AFP.
To determine whether LMAN local circuitry transforms or simply relays
song-related auditory information to vocal control neurons, it is
essential to distinguish local from extrinsic contributions to LMAN's
auditory selectivity. In vivo intracellular recordings
from LMAN projection neurons, coupled with local circuit inactivation,
reveal that much of LMAN's song selectivity is supplied by its
extrinsic inputs, but selective blockade of GABA receptors indicates
that local inhibition is required for the expression of song
selectivity. Therefore, LMAN neurons receive highly song-selective
information, but LMAN's local circuitry can mask these selective
inputs, providing a mechanism for context-dependent auditory feedback.
Key words:
auditory selectivity; song selectivity; birdsong; zebra
finch; LMAN; in vivo; intracellular; local circuitry; inactivation; GABA; bicuculline
Copyright © 2000 Society for Neuroscience 0270-6474/00/20145437-12$05.00/0
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