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The Journal of Neuroscience, July 15, 2000, 20(14):5461-5467
Synaptic Interactions between Thalamic Inputs to Simple Cells in Cat Visual Cortex
W. Martin Usrey1, 2, Jose-Manuel Alonso1, 3, and R. Clay Reid1, 2 1 Laboratory of Neurobiology, The Rockefeller University, New York, New York 10021, 2 Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, and 3 Department of Psychology, University of Connecticut, Storrs Mansfield, Connecticut 06269
We performed experiments in the cat geniculocortical pathway, in vivo, to examine how presynaptic spikes interact to influence the firing of postsynaptic targets. In particular, we asked (1) how do multiple spikes from a single presynaptic neuron interact to influence the firing of a postsynaptic target (homosynaptic interactions), (2) how do spikes from two different presynaptic neurons interact (heterosynaptic interactions), and (3) what is the time course of homosynaptic and heterosynaptic interactions? We found that both homosynaptic and heterosynaptic interactions increase the likelihood of driving a postsynaptic spike, although with different time courses. For two spikes traveling down a single geniculate axon, the second spike is more effective than the first for ~15 msec. For two spikes on separate axons, the interaction is faster (~7 msec duration, ~2.5 msec time constant). Thus changes in firing rate are perhaps best relayed by homosynaptic interactions, whereas heterosynaptic interactions may help detect coincident spikes from different thalamic inputs.
Key words: Key words: lateral geniculate nucleus; thalamus; Area 17; geniculocortical; coincidence detection
Copyright © 2000 Society for Neuroscience 0270-6474/00/20145461-07$05.00/0
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