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The Journal of Neuroscience, July 15, 2000, 20(14):5516-5525
Timing Mechanisms in the Cerebellum: Testing Predictions of a Large-Scale Computer Simulation
Javier F. Medina, Keith S. Garcia, William L. Nores, Nichole M. Taylor, and Michael D. Mauk W. M. Keck Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, Texas 77030
We used large-scale computer simulations of eyelid conditioning to investigate how the cerebellum generates and makes use of temporal information. In the simulations the adaptive timing displayed by conditioned responses is mediated by two factors: (1) different sets of granule cells are active at different times during the conditioned stimulus (CS), and (2) responding is not only amplified at reinforced times but also suppressed at unreinforced times during the CS. These factors predict an unusual pattern of responding after partial removal of the cerebellar cortex that was confirmed using small, electrolytic lesions of cerebellar cortex. These results are consistent with timing mechanisms in the cerebellum that are similar to Pavlov's "inhibition of delay" hypothesis.
Key words: LTD; LTP; eyelid conditioning; Pavlov; timing; simulation; cerebellum
Copyright © 2000 Society for Neuroscience 0270-6474/00/20145516-10$05.00/0
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